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Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues

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Abstract

Epidemiological and experimental studies show that the risk of cardiovascular and metabolic diseases at adulthood is inversely related to the weight at birth. Although with less evidence, low birth weight has been suggested to increase the risk of chronic kidney disease (CKD). It is well established that the developmental programming of arterial hypertension and of renal disease involves in particular renal factors, especially nephron endowment, which is reduced in low birth weight and maternal diabetes situations. Experimental studies, especially in rodents, have demonstrated the long-term influence of postnatal nutrition and/or postnatal growth on cardiovascular, metabolic and renal functions, while human data are scarce on this issue. Vascular and renal diseases appear to have a “multihits” origin, with reduced nephron number the initial hit and rapid postnatal growth the second hit. This review addresses the current understanding of the role of the kidney, both as a mechanism and as a target, in the developmental origins of adult disease theory, with a particular focus on the long-term effects of postnatal growth and nutrition.

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  1. Division of Neonatology, Hôpital la Conception, Assistance Publique-Hôpitaux de Marseille, 147 Boulevard Baille, 13385, Marseille, France

    Umberto Simeoni, Isabelle Ligi & Farid Boubred

  2. INSERM UMR608, Faculté de Pharmacie, Université de la Méditerranée, Marseille, France

    Umberto Simeoni, Isabelle Ligi, Christophe Buffat & Farid Boubred

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Correspondence to Umberto Simeoni.

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Simeoni, U., Ligi, I., Buffat, C. et al. Adverse consequences of accelerated neonatal growth: cardiovascular and renal issues. Pediatr Nephrol 26, 493–508 (2011). https://doi.org/10.1007/s00467-010-1648-1

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