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Resolution of sleep-disordered breathing in a dialysis-dependent child post-renal transplantation

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Abstract

This case alerts paediatricians and renal physicians to the potential for significant sleep-disordered breathing in children with renal disease, particularly those with end stage kidney disease requiring dialysis. In some cases, management of the underlying renal disease may result in amelioration of the sleep-disordered breathing. Proactive sleep history taking and formal sleep monitoring in experienced centres may be indicated for these children to limit morbidity, especially if respiratory support is indicated.

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References

  1. Wagner N, Wagner KD, Afanetti M, Nevo F, Antignac C, Michiels JF, Schedl A, Berard E (2008) A novel Wilms’ tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema. Pediatr Nephrol 23(9):1445–1453

    Article  Google Scholar 

  2. American Thoracic Society (1996) Standards and indications for cardiorespiratory sleep studies in children. Am J Respir Crit Care Med 153(2):866-878

    Article  Google Scholar 

  3. Rechtschaffen A, Kales A (eds) (1968) A manual of standardized terminology. Techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service/Brain Research Institute, Los Angeles

  4. Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M, Gigli GL (2006) Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant 21(1):184–190

    Article  Google Scholar 

  5. Parker K (2003) Sleep disturbances in dialysis patients. Sleep Med Rev 7(2):131–143

    Article  Google Scholar 

  6. Davis I, Baron J, O’Riordan A, Rosen C (2005) Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol 20(1):69–75

    Article  Google Scholar 

  7. Georgalas C, Babar-Craig H, Arora A, Narula A (2007) Health Outcome measurements in children with sleep disordered breathing. Clin Otolaryngol 32(4):268–274

    Article  CAS  Google Scholar 

  8. Rosen C, Palermo T, Larkin E, Redline S (2002) Health-related quality of life and sleep-disordered breathing in children. Sleep 25(6):657–666

    Article  Google Scholar 

  9. Nieto F, Young T, Lind B, Shahar E, Samet J, Redline S, D’Agostino RB, Newman AB, Lebowitz MD, Pickering TG (2000) Association of sleep-disordered breathing, sleep apnoea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283(14):1829–1836

    Article  CAS  Google Scholar 

  10. Mendelson W, Wadhwa N, Greenberg H, Gujavarty K, Bergofsky E (1990) Effects of hemodialysis on sleep apnea syndrome in end-stage renal disease. Clin Nephrol 33(5):247–251

    CAS  PubMed  Google Scholar 

  11. Kimmel P, Miller G, Mendelson W (1989) Sleep apnea syndrome in chronic renal disease. Am J Med 86(3):308–314

    Article  CAS  Google Scholar 

  12. Hamilton R, Epstein P, Henderson L, Edelman N, Fishman A (1976) Control of breathing in uremia: ventilatory response to CO2 after hemodialysis. J Appl Physiol 41(2):216–222

    Article  CAS  Google Scholar 

  13. Auckley D, Schmidt-Nowara W, Brown L (1999) Reversal of sleep apnea hypopnea syndrome in end-stage renal disease after kidney transplantation. Am J Kidney Dis 34(4):739–744

    Article  CAS  Google Scholar 

  14. Perrone J, Hoffman R (1996) Compensatory hypoventilation in severe metabolic alkalosis. Acad Emerg Med 3(10):981–982

    Article  CAS  Google Scholar 

  15. Javaheri S, Shore N, Rose B, Kazemi H (1982) Compensatory hypoventilation in metabolic alkalosis. Chest 81(3):296–301

    Article  CAS  Google Scholar 

  16. Tuller M, Mehdi F (1971) Compensatory hypoventilation and hypercapnia in primary metabolic alkalosis. Am J Med 50:281–290

    Article  CAS  Google Scholar 

  17. Haas S, Schmitt C, Arbeiter K, Bonzel K, Fischbach M, John U, Pieper AK, Schaub TP, Passlick-Deetjen J, Mehls O, Schaefer F (2003) Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis. J Am Soc Nephrol 14(10):2632–2638

    Article  Google Scholar 

  18. Canepa A, Verrina E, Perfumo F (2008) Use of new peritoneal dialysis solutions in children. Kidney Int 73:S137–S144

    Article  Google Scholar 

  19. Hanly P, Pierratos A (2001) Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis. N Engl J Med 344(2):102–107

    Article  CAS  Google Scholar 

  20. Santiago T, Edelman R, Fishman A (1975) The effects of anemia on the ventilatory response to transient and steady-state hypoxia. J Clin Invest 55(2):410–418

    Article  CAS  Google Scholar 

  21. Descamps-Latscha B, Herbelin A, Nguyen A, Raux-Lombard P, Zingroff J, Moynot A, Verger C, Dahmane D, de Groote D, Jungers P, Dayer JM (1995) Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes. J Immunol 154(2):882–892

    CAS  PubMed  Google Scholar 

  22. Entzian P, Linneman K, Schlaak M, Zabel P (1996) Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153(3):1080–1096

    Article  CAS  Google Scholar 

  23. Chen M, Keens T (2004) Congenital central hypoventilation syndrome: not just another rare disorder. Paediatr Resp Rev 5(3):182–189

    Article  Google Scholar 

  24. Bisgard GE, Kressin NA, Nielsen AM, Daristotle L, Smith CA, Forster HV (1987) Dopamine blockade alters ventilatory acclimatization to hypoxia in goats. Respir Physiol 69(2):245–255

    Article  CAS  Google Scholar 

  25. Beecroft J, Zaltzman J, Prasad R, Meliton G, Hanly P (2007) Impact of kidney transplantation on sleep apnoea in patients with end-stage renal disease. Nephrol Dial Transplant 22(10):3028–3033

    Article  Google Scholar 

  26. Langevin B, Fouque D, Leger P, Robert D (1993) Sleep apnea syndrome and end stage renal disease. Cure after renal transplantation. Chest 103(5):1330–1335

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank the parents for consenting for their child’s case to be published.

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Correspondence to Elizabeth A. Edwards.

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Ball, E., Kara, T., McNamara, D. et al. Resolution of sleep-disordered breathing in a dialysis-dependent child post-renal transplantation. Pediatr Nephrol 25, 173–177 (2010). https://doi.org/10.1007/s00467-009-1272-0

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  • DOI: https://doi.org/10.1007/s00467-009-1272-0

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