Abstract
This case alerts paediatricians and renal physicians to the potential for significant sleep-disordered breathing in children with renal disease, particularly those with end stage kidney disease requiring dialysis. In some cases, management of the underlying renal disease may result in amelioration of the sleep-disordered breathing. Proactive sleep history taking and formal sleep monitoring in experienced centres may be indicated for these children to limit morbidity, especially if respiratory support is indicated.
References
Wagner N, Wagner KD, Afanetti M, Nevo F, Antignac C, Michiels JF, Schedl A, Berard E (2008) A novel Wilms’ tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema. Pediatr Nephrol 23(9):1445–1453
American Thoracic Society (1996) Standards and indications for cardiorespiratory sleep studies in children. Am J Respir Crit Care Med 153(2):866-878
Rechtschaffen A, Kales A (eds) (1968) A manual of standardized terminology. Techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service/Brain Research Institute, Los Angeles
Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M, Gigli GL (2006) Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant 21(1):184–190
Parker K (2003) Sleep disturbances in dialysis patients. Sleep Med Rev 7(2):131–143
Davis I, Baron J, O’Riordan A, Rosen C (2005) Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol 20(1):69–75
Georgalas C, Babar-Craig H, Arora A, Narula A (2007) Health Outcome measurements in children with sleep disordered breathing. Clin Otolaryngol 32(4):268–274
Rosen C, Palermo T, Larkin E, Redline S (2002) Health-related quality of life and sleep-disordered breathing in children. Sleep 25(6):657–666
Nieto F, Young T, Lind B, Shahar E, Samet J, Redline S, D’Agostino RB, Newman AB, Lebowitz MD, Pickering TG (2000) Association of sleep-disordered breathing, sleep apnoea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283(14):1829–1836
Mendelson W, Wadhwa N, Greenberg H, Gujavarty K, Bergofsky E (1990) Effects of hemodialysis on sleep apnea syndrome in end-stage renal disease. Clin Nephrol 33(5):247–251
Kimmel P, Miller G, Mendelson W (1989) Sleep apnea syndrome in chronic renal disease. Am J Med 86(3):308–314
Hamilton R, Epstein P, Henderson L, Edelman N, Fishman A (1976) Control of breathing in uremia: ventilatory response to CO2 after hemodialysis. J Appl Physiol 41(2):216–222
Auckley D, Schmidt-Nowara W, Brown L (1999) Reversal of sleep apnea hypopnea syndrome in end-stage renal disease after kidney transplantation. Am J Kidney Dis 34(4):739–744
Perrone J, Hoffman R (1996) Compensatory hypoventilation in severe metabolic alkalosis. Acad Emerg Med 3(10):981–982
Javaheri S, Shore N, Rose B, Kazemi H (1982) Compensatory hypoventilation in metabolic alkalosis. Chest 81(3):296–301
Tuller M, Mehdi F (1971) Compensatory hypoventilation and hypercapnia in primary metabolic alkalosis. Am J Med 50:281–290
Haas S, Schmitt C, Arbeiter K, Bonzel K, Fischbach M, John U, Pieper AK, Schaub TP, Passlick-Deetjen J, Mehls O, Schaefer F (2003) Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis. J Am Soc Nephrol 14(10):2632–2638
Canepa A, Verrina E, Perfumo F (2008) Use of new peritoneal dialysis solutions in children. Kidney Int 73:S137–S144
Hanly P, Pierratos A (2001) Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis. N Engl J Med 344(2):102–107
Santiago T, Edelman R, Fishman A (1975) The effects of anemia on the ventilatory response to transient and steady-state hypoxia. J Clin Invest 55(2):410–418
Descamps-Latscha B, Herbelin A, Nguyen A, Raux-Lombard P, Zingroff J, Moynot A, Verger C, Dahmane D, de Groote D, Jungers P, Dayer JM (1995) Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes. J Immunol 154(2):882–892
Entzian P, Linneman K, Schlaak M, Zabel P (1996) Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153(3):1080–1096
Chen M, Keens T (2004) Congenital central hypoventilation syndrome: not just another rare disorder. Paediatr Resp Rev 5(3):182–189
Bisgard GE, Kressin NA, Nielsen AM, Daristotle L, Smith CA, Forster HV (1987) Dopamine blockade alters ventilatory acclimatization to hypoxia in goats. Respir Physiol 69(2):245–255
Beecroft J, Zaltzman J, Prasad R, Meliton G, Hanly P (2007) Impact of kidney transplantation on sleep apnoea in patients with end-stage renal disease. Nephrol Dial Transplant 22(10):3028–3033
Langevin B, Fouque D, Leger P, Robert D (1993) Sleep apnea syndrome and end stage renal disease. Cure after renal transplantation. Chest 103(5):1330–1335
Acknowledgements
We would like to thank the parents for consenting for their child’s case to be published.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ball, E., Kara, T., McNamara, D. et al. Resolution of sleep-disordered breathing in a dialysis-dependent child post-renal transplantation. Pediatr Nephrol 25, 173–177 (2010). https://doi.org/10.1007/s00467-009-1272-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-009-1272-0