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Antioxidant status of children with acute renal failure

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Abstract

The production of free radicals can cause renal injury and play a role in the pathogenesis of acute renal failure (ARF). The indirect markers of reactive oxygen species (ROS) were evaluated in children with ARF and controls. Forty patients with ARF aged 0–10 years were selected. Twenty age- and gender-matched healthy children were included as controls. Plasma malondialdehyde, protein carbonyl, nitrite, copper, ascorbic acid, zinc, and ceruloplasmin levels were estimated in patients with ARF and controls. The plasma malondialdehyde (p < 0.01), copper (p < 0.001), ascorbic acid (p < 0.05), and ceruloplasmin (p < 0.001) levels were significantly raised in ARF patients in comparison with controls. Significantly higher levels of plasma malondialdehyde (p < 0.01), nitrite (p < 0.001), copper (p < 0.001), and ceruloplasmin (p < 0.001) and lower plasma zinc (p < 0.01) were found in ARF nonsurvivors in comparison with survivors. The cutoff levels of plasma nitrite and ceruloplasmin were found to be most accurate in predicting mortality in ARF patients and had maximum sensitivity (100%) and specificity (60.7%) among the parameters studied. In conclusion, the increased levels of oxidants and antioxidants suggest the production of ROS and their possible role in ARF pathogenesis. Plasma nitrite and ceruloplasmin concentrations demonstrated predictive ability in relation to mortality.

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Abbreviations

ARF:

acute renal failure

MDA:

malondialdehyde

ROS:

reactive oxygen species

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Authors and Affiliations

  1. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Om Prakash Mishra, Vishal Pooniya & Rajniti Prasad

  2. Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Ziledar Ali

  3. Department of Botany, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India

    Ram Sanmukh Upadhyay

Authors
  1. Om Prakash Mishra
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  2. Vishal Pooniya
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  3. Ziledar Ali
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  4. Ram Sanmukh Upadhyay
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  5. Rajniti Prasad
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Corresponding author

Correspondence to Om Prakash Mishra.

Additional information

Financial Support: The study was supported by Departmental Research Grant of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.

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Mishra, O.P., Pooniya, V., Ali, Z. et al. Antioxidant status of children with acute renal failure. Pediatr Nephrol 23, 2047–2051 (2008). https://doi.org/10.1007/s00467-008-0875-1

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  • DOI: https://doi.org/10.1007/s00467-008-0875-1

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