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Mild course of Puumala nephropathy in children in an area with sporadic occurrence Hantavirus infection

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Abstract

The first three children with Puumala virus nephropathy diagnosis in the Czech Republic are reported on. A boy and two girls were admitted with symptoms of interstitial nephritis. The medical history in all children revealed flu-like symptoms. All patients were mildly pyrexial and had elevated erythrocytes sedimentation rate, C-reactive protein and low hemoglobin levels. Serum creatinine levels were elevated and proteinuria exceeded 700 mg/L in all children. Tubular proteinuria, glycosuria, high urinary N-acetyl-β-D-glucosaminidase levels and α-1-microglobulin levels confirmed the tubular lesion. Renal biopsies revealed a uniform pattern and showed non-purulent interstitial nephritis in all patients. Puumala virus antigen antibodies were detected in the plasma. All patients were treated with steroids and urine abnormalities and renal function returned to normal within 4 weeks. Hantavirus infection should be considered as one of possible causes of interstitial nephritis with decreased GFR in children even in areas with a low incidence of this infection.

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Authors and Affiliations

  1. Department of Pediatrics, 2nd Medical School, Charles University, Prague and University Hospital Motol, V Uvalu 84, 150 06, Prague 5, Czech Republic

    Jiří Dusek

  2. National Institute of Public Health, Srobarova 48, 100 42, Prague 10, Czech Republic

    Milan Pejcoch

  3. Department of Pediatrics, Thomayer Teaching Hospital, Videnska 800, 140 59, Prague 4, Czech Republic

    Alexander Kolsky

  4. Department of Pediatrics, University Hospital Motol and 2nd Medical School, V Uvalu 84, 150 06, Prague 5, Czech Republic

    Tomas Seeman, Karel Vondrak & Jan Janda

  5. Department of Pathology, University Hospital Motol and 2nd Medical School, V Uvalu 84, 150 06, Prague 5, Czech Republic

    Josef Stejskal

  6. Department of Pediatrics, District Hospital, Kyjevska 44, 532 03, Pardubice, Czech Republic

    Vladimir Nemec

Authors
  1. Jiří Dusek
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  2. Milan Pejcoch
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  3. Alexander Kolsky
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  4. Tomas Seeman
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  5. Vladimir Nemec
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  6. Josef Stejskal
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  7. Karel Vondrak
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  8. Jan Janda
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Correspondence to Jiří Dusek.

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Dusek, J., Pejcoch, M., Kolsky, A. et al. Mild course of Puumala nephropathy in children in an area with sporadic occurrence Hantavirus infection. Pediatr Nephrol 21, 1889–1892 (2006). https://doi.org/10.1007/s00467-006-0250-z

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  • DOI: https://doi.org/10.1007/s00467-006-0250-z

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