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Stature in children with chronic kidney disease: analysis of NAPRTCS database

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Abstract

Despite recent advances in the management of children with chronic kidney disease (CKD), growth remains suboptimal. The purpose of this study was to evaluate factors associated with short stature in children with CKD. We evaluated the chronic renal failure registry of the North American Pediatric Renal Transplant Cooperative Studies (NAPRTCS) to determine the relations among primary diagnosis, age, race, residual renal function, acidosis, anemia, serum phosphorous, calcium, parathyroid hormone (PTH), albumin, and height at entry into the registry in children with CKD. A total of 5,615 patients were entered into the registry between January 1994 and January 2004. We found that older patients, those with glomerular filtration rate (GFR) >50 ml min−1 1.73 m−2, black patients and patients with focal segmental glomerulosclerosis (FSGS) were at lower risk of being short at entry. Anemia (hematocrit below 33%) was an independent risk factor for short stature. Acidosis, serum phosphorous, calcium, albumin and PTH at registration were poor predictors of short stature. Age, race, primary diagnosis, and residual renal function were associated with short stature in children with CKD.

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Abbreviations

GFR:

Glomerular filtration rate

CKD:

Chronic kidney disease stage 2–4 as defined in [1]

NAPRTCS:

North American Pediatric Renal Transplant Cooperative Studies

SDS:

Standard deviation score

rhGH:

Recombinant human growth hormone

ClCr :

Estimated creatinine clearance as described in [14] and [15]

PTH:

Parathyroid hormone

FSGS:

Focal segmental glomerulosclerosis

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Acknowledgement

We are indebted to the secretarial support of Ms. Sharon Blend.

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Authors and Affiliations

  1. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Mouin G. Seikaly

  2. Children’s Medical Center of Dallas, 1935 Motor Street, Dallas, TX, 75235, USA

    Mouin G. Seikaly & Nina Salhab

  3. Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA

    Debbie Gipson

  4. Department of Pediatrics, University of Alberta, Edmonton, AB, Canada

    Verna Yiu

  5. Department of Pediatrics, The EMMES Corporation, Rockville, MD, USA

    Donald Stablein

Authors
  1. Mouin G. Seikaly
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  2. Nina Salhab
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  4. Verna Yiu
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  5. Donald Stablein
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Correspondence to Mouin G. Seikaly.

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Seikaly, M.G., Salhab, N., Gipson, D. et al. Stature in children with chronic kidney disease: analysis of NAPRTCS database. Pediatr Nephrol 21, 793–799 (2006). https://doi.org/10.1007/s00467-006-0040-7

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  • DOI: https://doi.org/10.1007/s00467-006-0040-7

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