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Report of an NIH task force on research priorities in chronic kidney disease in children

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References

  1. Drozdz D, Drozdz M, Gretz N, Mohring K, Mehls O, Scharer K (1998) Progression to end-stage renal disease in children with posterior urethral valves. Pediatr Nephrol 12:630–636

    CAS  PubMed  Google Scholar 

  2. Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC (2005) Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol 20:255–260

    PubMed  Google Scholar 

  3. Davis ID, Baron J, O’Riordan MA, Rosen CL (2005) Sleep disturbances in pediatric dialysis patients. Pediatr Nephrol 20:69–75

    PubMed  Google Scholar 

  4. De Palo T, Giordano M, Palumbo F, Bellantuono R, Messina G, Colella V, Caringella AD (2004) Clinical experience with darbepoietin alfa (NESP) in children undergoing hemodialysis. Pediatr Nephrol 19:337–340

    Google Scholar 

  5. Stoll ML, Gauthier BG, Vergara M, Ramek J, Frank R, Trachtman H (2004) Efficacy of losartan in the treatment of erythrocytosis in a young adult with CRF. Pediatr Nephrol 19:120–121

    PubMed  Google Scholar 

  6. Everdell NL, Coulthard MG, Crosier J, Keir MJ (2005) A machine for haemodialysing very small infants. Pediatr Nephrol 20:636–643

    PubMed  Google Scholar 

  7. Fischbach M, Edefonti A, Schroder C, Watson A (2005) Hemodialysis in children: general practical guidelines. Pediatr Nephrol 20:1054–1066

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Maroti Z, Nemeth I, Turi S, Karg E, Ugocsai P, Endreffy E (2004) Heme oxygenase 1 expression in young uremic patients on hemodialysis. Pediatr Nephrol 19:426–431

    PubMed  Google Scholar 

  9. Taylor CM, Chua C, Howie AJ, Risdon RA (2004) Clinico-pathological findings in diarrhoea-negative haemolytic uraemic syndrome. Pediatr Nephrol 19:419–425

    CAS  PubMed  Google Scholar 

  10. Malaga S, Pardo R, Malaga I, Orejas G, Fernandez-Toral J (2005) Renal involvement in Down syndrome. Pediatr Nephrol 20:614–617

    PubMed  Google Scholar 

  11. Neu AM, Fivush BA, Warady BA, Watkins SL, Friedman AL, Brem AS, Goldstein S, Frankenfield DL (2003) Longitudinal analysis of intermediate outcomes in adolescent hemodialysis patients. Pediatr Nephrol 18:1172–1176

    PubMed  Google Scholar 

  12. NAPRTCS Annual Report (2002) http://www.naprtcs.org

  13. U.S. Renal Data System, USRDA 2001 Annual Data Report (2001) Atlas of end-stage renal disease in the United States, National Institutes of Diabetes and Digestive and Kidney Disease. Bethesda, MD, USA, www.usrds.org

  14. Seikaly MG, Ho PL, Emmett L, Fine RN, Tejani A (2003) Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS. Pediatr Nephrol 18:796–804

    PubMed  Google Scholar 

  15. Groop L, Orho-Melander M (2001) The dysmetabolic syndrome. J Intern Med 250:105–120

    CAS  PubMed  Google Scholar 

  16. www.kidney.org/professionals/doqi/guidelineindex.cfm (National Kidney Foundation), Chronic Kidney Disease Guidelines

  17. Fletcher R, Fletcher S, Wagner E (1996) Clinical epidemiology: The essentials, 3rd edn. Williams and Wilkins, Baltimore, pp 135–140

    Google Scholar 

  18. Ahuja TS, Abbott KC, Pack L, Kuo YF (2004) HIV-associated nephropathy and end-stage renal disease in children in the United States. Pediatr Nephrol 19:808–811

    PubMed  Google Scholar 

  19. Ardissino G, Testa S, Dacco V, Vigano S, Taioli E, Claris-Appiani A, Procaccio M, Avolio L, Ciofani A, Dello Strologo L, Montini G (2004) Proteinuria as a predictor of disease progression in children with hypodysplastic nephropathy. Data from the Ital Kid Project. Pediatr Nephrol 19:172–177

    PubMed  Google Scholar 

  20. Litwin M (2004) Risk factors for renal failure in children with non-glomerular nephropathies. Pediatr Nephrol 19:178–186

    PubMed  Google Scholar 

  21. Filler G, Payne RP, Orrbine E, Clifford T, Drukker A, McLaine PN (2005) Changing trends in the referral patterns of pediatric nephrology patients. Pediatr Nephrol 20:603–608

    PubMed  Google Scholar 

  22. Gordis L (2000) Epidemiology, 2nd edn. Saunders, Philadelphia

  23. Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E (2005) High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. Pediatr Nephrol 20:474–477

    PubMed  Google Scholar 

  24. http://omhrc.gov/healthy2000book/tab8.html (2000) Healthy People 2010

  25. Neu A, Ho P, MacDonald R, Warady B (2002) Chronic dialysis in children and adolescents. The 2001 NAPRTCS Annual Report. Pediatr Nephrol 17:656–663

    PubMed  Google Scholar 

  26. Furth SL, Stablein D, Fine RN, Powe NR, Fivush BA (2002) Adverse clinical outcomes associated with short stature at dialysis initiation. A report of the North American Pediatric Renal Transplant Cooperative Study. Pediatrics 109:909–913

    PubMed  Google Scholar 

  27. Fine RN, Ho PL, Tejani A (2001) The contribution of renal transplantation to final adult height. A report of the North American Pediatric Cooperative Study (NAPRTCS). Pediatr Nephrol 16:951–961

    CAS  PubMed  Google Scholar 

  28. Bartosh SM, Fine RN, Sullivan EK (2001) Outcomes after transplantation of young patients with systemic lupus erythematosus. A report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Transplantation 72:973–978

    CAS  PubMed  Google Scholar 

  29. Fine RN, Sullivan EK, Kuntze J, Blethen S, Kohaut E (2000) The impact of recombinant human growth hormone treatment during chronic renal insufficiency on renal transplant recipients. J Pediatr 3:376–382

    Google Scholar 

  30. Brouhard BH, Donaldson LA, Lawry KW, McGowan KRB, Drotar D, David I, Rose S, Cohn RA, Tejani A (2000) Cognitive functioning in children on dialysis and post-transplantation. Pediatr Transplant 4:261–267

    CAS  PubMed  Google Scholar 

  31. Fivush BA, Jabs K, Neu AM, Sullivan EK, Feld LG, Kohaut E, Fine RN (1998) Chronic renal insufficiency in children and adolescents. The 1996 Annual Report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Pediatr Nephrol 12:328–337

    CAS  PubMed  Google Scholar 

  32. Warady BA, Hebert D, Sullivan EK, Alexander SR, Tejani A (1997) Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents. The 1995 Annual Report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 11:49–64

    CAS  PubMed  Google Scholar 

  33. Furth SL, Neu AM, Sullivan EK, Gensler G, Tejani A (1997) Immunization practices in children with renal disease. A report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 11:443–446

    CAS  PubMed  Google Scholar 

  34. van der Heijden BJ, van Dijk PC, Verrier-Jones K, Jager KJ, Briggs JD (2004) Renal replacement therapy in children: data from 12 registries in Europe. Pediatr Nephrol 19:213–221

    Google Scholar 

  35. Chesney RW (2005) The future of pediatric nephrology. Pediatr Nephrol 20:867–871

    PubMed  Google Scholar 

  36. Lilien MR, Schroder CH, Levtchenko EN, Koomans HA (2004) Growth hormone therapy influences endothelial function in children with renal failure. Pediatr Nephrol 19:785–789

    PubMed  Google Scholar 

  37. Rabkin R, Sun DF, Chen Y, Tan J, Schaefer F (2005) Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr Nephrol 20:313–318

    PubMed  Google Scholar 

  38. Santos F, Carbajo-Perez E, Rodriguez J, Fernandez-Fuente M, Molinos I, Amil B, Garcia E (2005) Alterations of the growth plate in chronic renal failure. Pediatr Nephrol 20:330–334

    PubMed  Google Scholar 

  39. Waller S, Ledermann S, Trompeter R, van’t Hoff W, Ridout D, Rees L (2003) Catch-up growth with normal parathyroid hormone levels in chronic renal failure. Pediatr Nephrol 18:1236–1241

    PubMed  Google Scholar 

  40. Dixon P, Iurilli J, Watson AR, Neill E, Foy J, Martin M (2004) Acceptability of a reformulated renal-specific micronutrient supplement. Pediatr Nephrol 19:1433–1434

    PubMed  Google Scholar 

  41. Kari JA, Rees L (2005) Growth hormone for children with chronic renal failure and on dialysis. Pediatr Nephrol 20:618–621

    PubMed  Google Scholar 

  42. Norman LJ, Macdonald IA, Watson AR (2004) Optimising nutrition in chronic renal insufficiency—growth. Pediatr Nephrol 19:1245–1252

    PubMed  Google Scholar 

  43. Norman LJ, Macdonald IA, Watson AR (2004) Optimising nutrition in chronic renal insufficiency—progression of disease. Pediatr Nephrol 19:1253–1261

    PubMed  Google Scholar 

  44. Tönshoff B, Kiepe D, Ciarmatori S (2005) Growth hormone/insulin-like growth factor system in children with chronic renal failure. Pediatr Nephrol 20:279–289

    Google Scholar 

  45. Ellis D (2000) Growth and renal function after steroid-free tacrolimus-based immunosuppression in children with renal transplants. Pediatr Nephrol 14:689–694

    CAS  PubMed  Google Scholar 

  46. Polinsky M, Kaiser B, Stover J (1987) Neurologic development of children with severe chronic renal failure from infancy. Pediatr Nephrol 1:157–165

    CAS  PubMed  Google Scholar 

  47. Warady B, Belden B, Kohaut EC (1999) Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy. Pediatr Nephrol 13:759–765

    CAS  PubMed  Google Scholar 

  48. Gipson DS, Wetherington CE, Duquette PJ, Hooper SR (2004) The nervous system and chronic kidney disease in children. Pediatr Nephrol 19:832–839

    PubMed Central  PubMed  Google Scholar 

  49. Fennell RS, Fennell EB, Carter RL, Mings EL, Klausner AB, Hurst JR (1990) Association between renal function and cognition in childhood chronic renal failure. Pediatr Nephrol 4:16–20

    CAS  PubMed  Google Scholar 

  50. Lawry KW, Brouhard BH, Cunningham RJ (1994) Cognitive functioning and school performance in children with renal failure. Pediatr Nephrol 8:326–329

    CAS  PubMed  Google Scholar 

  51. Hulstijn-Dirkmaat GM, Damhuis IH, Jetten ML, Koster AM, Schröder C (1995) The cognitive development of pre-school children treated for chronic renal failure. Pediatr Nephrol 9:464–469

    CAS  PubMed  Google Scholar 

  52. Eijsermans RM, Creemers DG, Helders PJ, Schröder CH (2004) Motor performance, exercise tolerance, and health-related quality of life in children on dialysis. Pediatr Nephrol 19:1262–1266

    PubMed  Google Scholar 

  53. Schärer K, Schmidt KG, Soergel M (1999) Cardiac function and structure in patients with chronic renal failure. Pediatr Nephrol 13:951–965

    Google Scholar 

  54. Mitsnefes MM, Daniels SR, Schwartz SM, Meyer RA, Khoury P, Strife CF (2000) Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatr Nephrol 14:898–902

    CAS  PubMed  Google Scholar 

  55. Dursun H, Kucukosmanoglu O, Noyan A, Ozbarlas N, Buyukcelik M, Soran M, Bayazit AK, Anarat A (2005) Mitral annular calcification and brown tumor of the rib in a child with chronic renal failure. Pediatr Nephrol 20:673–675

    PubMed  Google Scholar 

  56. Poyrazoglu HM, Dusunsel R, Narin F, Gunduz Z, Narin N, Karakukcu M, Tahan F (2004) Homocysteine and left ventricular hypertrophy in children with chronic renal failure. Pediatr Nephrol 19:193–198

    PubMed  Google Scholar 

  57. Hopp L, Gilboa N, Kurland G, Weichler N, Orchard TJ (1994) Acute myocardial infarction in a young boy with nephrotic syndrome: A case report and review of the literature. Pediatr Nephrol 8:290–294

    CAS  PubMed  Google Scholar 

  58. Adedoyin O, Frank R, Vento S, Vergara M, Gauthier B, Trachtman H (2004) Cardiac disease in children with primary glomerular disorders-role of focal segmental glomerulosclerosis. Pediatr Nephrol 19:408–412

    PubMed  Google Scholar 

  59. Parekh RS, Gidding SS (2005) Cardiovascular complications in pediatric end-stage renal disease. Pediatr Nephrol 20:125–131

    PubMed  Google Scholar 

  60. Querfeld U (2004) The clinical significance of vascular calcification in young patients with end-stage renal disease. Pediatr Nephrol 19:478–484

    PubMed  Google Scholar 

  61. Sheth RD, Perez MD, Goldstein SL (2003) Cardiovascular calcifications in pediatric patients receiving maintenance dialysis. Pediatr Nephrol 18:810–813

    PubMed  Google Scholar 

  62. Bennett-Richards K, Katterhorn M, Donald A, Oakley G, Varghese Z, Rees L, Deanfield JE (2002) Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure. Circulation 105:1810–1815

    CAS  PubMed  Google Scholar 

  63. Müller T, Koeppe S, Arbeiter K, Luckner D, Salzer U, Balzar E, Aufricht C (2003) Serum lipid pattern unifies following renal transplantation in children. Pediatr Nephrol 18:939–942

    Google Scholar 

  64. Metry G, Wikstrom B, Falind S, Sandhagen B, Linde T, Beshara S, Langstrom B, Danielson BG (1999) Effect of normalization of hematocrit on brain circulation and metabolism in hemodialysis patients. J Am Soc Nephrol 10:854–863

    CAS  PubMed  Google Scholar 

  65. Pickett JL, Theberge DC, Brown WS, Schweitzer SU, Nissenson AR (1999) Normalizing hematocrit in dialysis patients improves brain function. Am J Kidney Dis 33:1122–1130

    CAS  PubMed  Google Scholar 

  66. MacDougall IC (2000) How to improve survival in pre-dialysis patients. Nephron 85 [Suppl 1]:15–22

    Google Scholar 

  67. Portoles J, Torralbo A, Martin P, Rodrigo J, Herrero JA, Barrientos A (1997) Cardiovascular effects of recombinant human erythropoietin in predialysis patients. Am J Kidney Dis 29:541–548

    CAS  PubMed  Google Scholar 

  68. Hayashi T, Suzuki A, Shoji T, Togawa M, Okada N, Tsubakihara Y, Imai E, Hori M (2000) Cardiovascular effect of normalizing the hematocrit level during erythropoietin therapy in predialysis patients with chronic renal failure. Am J Kidney Dis 35:250–256

    CAS  PubMed  Google Scholar 

  69. Moreno F, Aracil FJ, Perez R, Valderrabano F (1996) Controlled study on the improvement of quality of life in elderly hemodialysis patients after correcting end-stage renal disease-related anemia with erythropoietin. Am J Kidney Dis 27:548–556

    CAS  PubMed  Google Scholar 

  70. Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Strife CF (2001) Changes in left ventricular mass in children and adolescents during chronic dialysis. Pediatr Nephrol 16:318–323

    CAS  PubMed  Google Scholar 

  71. Foley RN, Parfrey PS, Sarnak MJ (1998) Cardiovascular disease in chronic renal disease. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32:S112–S119

    CAS  PubMed  Google Scholar 

  72. Roth D, Smith R, Schulman G, Steinman T, Hatch F, Rudnick M, Sloand J, Freedman B, Williams W, Shadur C, Benz R, Teehan BP, Revicki D, Sarokhan B, Abels R (1994) Effects of recombinant human erythropoietin on renal function in chronic renal failure predialysis patients. Am J Kidney Dis 24:777–784

    CAS  PubMed  Google Scholar 

  73. US Renal Data System: Excerpts from the USRDA 2001 Annual Data Report. Am J Kidney Dis 38 [Suppl 243]:S1–S248

  74. Silverberg DS, Wexler D, Blum M, Keren G, Sheps D, Leibovitch E, Brosh D, Laniado S, Schwartz D, Yachnin T, Shapira I, Garush D, Baruch R, Koifman B, Kaplan C, Steinbruch S, Iaina A (2000) The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function, functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardio 35:1737–1744

    CAS  Google Scholar 

  75. Gerson A, Fivush BA, Kaskel F, Weiss L, Powe NR, Furth SL (2001) Functional outcomes in adolescents with renal failure: assessing a general health status questionnaire. Perit Dial Int 21 [Suppl]:S89

  76. Fadrowski JJ, Furth SL, Fivush BA (2004) Anemia in pediatric dialysis patients in end-stage renal disease network 5. Pediatr Nephrol 19:1029–1034

    PubMed  Google Scholar 

  77. Warady BA, Ho M (2003) Morbidity and mortality in children with anemia at initiation of dialysis. Pediatr Nephrol 18:1055–1062

    PubMed  Google Scholar 

  78. Gillespie RS, Wolf FM (2004) Intravenous iron therapy in pediatric hemodialysis patients: a meta-analysis. Pediatr Nephrol 19:662–666

    PubMed  Google Scholar 

  79. Ruiz-Jaramillo ML, Guizar-Mendoza JM, Gutierrez-Navarro MJ, Dubey-Ortega LA, Amador-Licona N (2004) Intermittent versus maintenance iron therapy in children on hemodialysis: a randomized study. Pediatr Nephrol 19:77–81

    Google Scholar 

  80. Schröder CH (2003) The management of anemia in pediatric peritoneal dialysis patients. Guidelines by an ad hoc European committee. Pediatr Nephrol 18:805–809

    Google Scholar 

  81. Warady BA, Kausz A, Lerner G, Brewer ED, Chadha V, Brugnara C, Dahl NV, Watkins SL (2004) Iron therapy in the pediatric hemodialysis population. Pediatr Nephrol 19:655–661

    PubMed  Google Scholar 

  82. Salusky IB, Ramirez JA, Oppenheim W, Gales B, Segre GV, Goodman WG (1994) Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD. Kidney Int 46:253–258

    Google Scholar 

  83. John MR, Goodman WG, Gao P, Cantor TL, Salusky IB, Juppner H (1999) A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab 84:4287–4290

    CAS  PubMed  Google Scholar 

  84. Bakr AM (2004) Bone mineral density and bone turnover markers in children with chronic renal failure. Pediatr Nephrol 19:1390–1393

    PubMed  Google Scholar 

  85. Levi R, Silver J (2005) Pathogenesis of parathyroid dysfunction in end-stage kidney disease. Pediatr Nephrol 20:342–345

    PubMed  Google Scholar 

  86. Schmitt CP, Homme M, Schaefer F (2005) Structural organization and biological relevance of oscillatory parathyroid hormone secretion. Pediatr Nephrol 20:346–351

    CAS  PubMed  Google Scholar 

  87. Schoenau E (2005) The “functional muscle-bone unit”: a two-step diagnostic algorithm in pediatric bone disease. Pediatr Nephrol 20:356–359

    PubMed  Google Scholar 

  88. Salusky IB, Kuizon BD, Belin TR, Ramirez JQ, Gales B, Segre GV, Goodman WG (1998) Intermittent calcitriol therapy in secondary hyperparathyroidism: A comparison between oral and intraperitoneal administration. Kidney Int 54:907–914

    CAS  PubMed  Google Scholar 

  89. Kuizon BD, Goodman WG, Juppner H, Boechat I, Nelson P, Gales B, Salusky IB (1998) Diminished linear growth during calcitriol therapy in children undergoing CCPD. Kidney Int 53:205–211

    CAS  PubMed  Google Scholar 

  90. Cunningham J (2004) New Vitamin D analogues for osteodystrophy in chronic kidney disease. Pediatr Nephrol 19:705–708

    PubMed  Google Scholar 

  91. Sanchez CP (2004) Chronotherapy of high-dose active Vitamin D(3): is evening dosing preferable? Pediatr Nephrol 19:722–723

    PubMed  Google Scholar 

  92. Waller S, Ridout D, Cantor T, Rees L (2005) Differences between “intact” PTH and 1–84 PTH assays in chronic renal failure and dialysis. Pediatr Nephrol 20:197–199

    PubMed  Google Scholar 

  93. Salusky IB, Juppner H (2004) New PTH assays and renal osteodystrophy. Pediatr Nephrol 19:709–713

    PubMed  Google Scholar 

  94. Oh J, Wunsch R, Turzer M, Bahner M, Raggi P, Querfeld U, Mehls O, Schaefer F (2002) Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 106:100–105

    PubMed  Google Scholar 

  95. Greenbaum LA, Grenda R, Qiu P, Restaino I, Wojtak A, Paredes A, Benador N, Melnick JZ, Williams LA, Salusky IB (2005) Intravenous calcitriol for treatment of hyperparathyroidism in children on hemodialysis. Pediatr Nephrol 20:622–630

    PubMed  Google Scholar 

  96. Drueke TB (2005) Treatment of secondary hyperparathyroidism of dialysis patients with calcimimetics as a valuable addition to established therapeutic means. Pediatr Nephrol 20:399–403

    PubMed  Google Scholar 

  97. Goodman WG (2003) Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol 18:1206–1210

    PubMed  Google Scholar 

  98. Sanchez CP, Kuizon BD, Abdella PA, Juppner H, Salusky IB, Goodman WG (2000) Impaired growth, delayed ossification, and reduced osteoclastic activity in the growth plate of calcium-supplemented rats with renal failure. Endocrinology 141:1536–1544

    CAS  PubMed  Google Scholar 

  99. Mahdavi H, Kuizon BD, Gales B, Wang HJ, Elashoff RM, Salusky IB (2003) Sevelamer hydrochloride: an effective phosphate binder in dialyzed children. Pediatr Nephrol 18:1260–1264

    PubMed  Google Scholar 

  100. Moe SM, Chen NX (2003) Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis. Pediatr Nephrol 18:969–975

    PubMed  Google Scholar 

  101. Rahn KH (2005) The role of calcium antagonists in patients with chronic renal failure. Pediatr Nephrol

  102. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB (2000) Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342:1478–1483

    CAS  PubMed  Google Scholar 

  103. Milliner DS, Zinsmeister AR, Leiberman E, Landing B (1990) Soft tissue calcification in pediatric patients with end-stage renal disease. Kidney Int 38:931–936

    CAS  PubMed  Google Scholar 

  104. Aggoun Y, Niaudet P, Laffont A, Sidi D, Kachaner J, Bonnett D (2000) Cardiovascular impact of end-stage renal insufficiency. Arch Mal Coeur Vaiss 93:1009–1013

    CAS  PubMed  Google Scholar 

  105. Awad JA, Morrow JD, Takahashi K, Roberts LJ 2nd (1993) Identification of non-cyclooxygenase-derived prostanoid (F-2 isoprostane) metabolites in human urine and plasma. J Biol Chem 268:4161–4169

    CAS  PubMed  Google Scholar 

  106. Bennett-Richards K, Katterhorn M, Donald A, Oakley G, Varghese Z, Bruckdorfer K, Deanfield JE, Rees L (2002) Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int 62:1372–1378

    CAS  PubMed  Google Scholar 

  107. Bolton CH, Downs LG, Victory JG, Dwight JF, Tomson CR, Mackness MI, Pinkney JH (2001) Endothelial dysfunction in chronic renal failure: roles of lipoprotein oxidation and pro-inflammatory cytokines. Nephrol Dial Transplant 16:1189–1197

    CAS  PubMed  Google Scholar 

  108. Kari J, Donald A, Vallance D, Bruckdorfer K, Leone A, Mullen M, Bunce T, Dorado B, Deanfield JE, Rees L (1997) Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 52:468–472

    CAS  PubMed  Google Scholar 

  109. Lilien MR, Stroes ES, Op’t Roodt J, deJongh S, Schroeder CH, Koomans HA (2003) Vascular function in children after renal transplantation. Am J Kidney Dis 41:684–691

    PubMed  Google Scholar 

  110. Misselwitz J, Franke S, Kauf E, John U, Stein G (2002) Advanced glycation end products in children with chronic renal failure and type 1 diabetes. Pediatr Nephrol 17:316–321

    PubMed  Google Scholar 

  111. Nairn J, Hodge G, Henning P (2005) Changes in leukocyte subsets: clinical implications for children with chronic renal failure. Pediatr Nephrol 20:190–196

    PubMed  Google Scholar 

  112. Nayir A, Bilge I, Kilicaslan I, Ander H, Emre S, Sirin A (2001) Arterial changes in paediatric haemodialysis patients undergoing renal transplantation. Nephrol Dial Transplant 16:2041–2047

    CAS  PubMed  Google Scholar 

  113. Panichi V, Migliori M, De Pietro S, Taccola D, Bianchi AM, Norpoth M, Metelli MR, Giovannini L, Tetta C, Palla R (2001) C-reactive protein in patients with chronic renal diseases. Ren Fail 23:551–562

    CAS  PubMed  Google Scholar 

  114. Parikh A, Sochett EB, McCrindle BW, Dipchand A, Daneman A, Daneman D (2000) Carotid artery distensibility and cardiac function in adolescents with type 1 diabetes. J Pediatr 137:465–469

    CAS  PubMed  Google Scholar 

  115. Sebokova K, Podracka L, Heidland A, Schinzel R (2001) Enhanced plasma levels of advanced glycation end products (AGE) and pro-inflammatory cytokines in children/adolescents with chronic renal insufficiency and after renal replacement therapy by dialysis and transplantation: Are they interrelated? Clin Nephrol 56 [Suppl 1]:S21–S26

  116. Spittle MA, Hoenich NA, Handelman GJ, Adhikarla R, Homel P, Levin NW (2001) Oxidative stress and inflammation in hemodialysis patients. Am J Kidney Dis 38:1408–1413

    CAS  PubMed  Google Scholar 

  117. Wever R, Boer P, Hijmering M, Stroes E, Verhaar M, Kastlein J, Versluis K, Lagerwerf F, van Rijn H, Koomans H, Rabelink T (1999) Nitric oxide production is reduced in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 19:1168–1172

    CAS  PubMed  Google Scholar 

  118. Yan SD, Schmidt AM, Anderson G (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors binding protein. J Biol Chem 269:9889–9897

    CAS  PubMed  Google Scholar 

  119. Zwolinska D, Medynska A, Szprynger K, Szczepanska M (2000) Serum concentration of IL-2, IL-6, TNF-alpha and their soluble receptors in children on maintenance hemodialysis. Nephron 86:441–446

    CAS  PubMed  Google Scholar 

  120. Dotsch J, Nusken K, Schroth M, Rascher W, Meissner U (2005) Alterations of leptin and ghrelin serum concentrations in renal disease: simple epiphenomena? Pediatr Nephrol 20:701–706

    PubMed  Google Scholar 

  121. Musial K, Zwolinska D, Polak-Jonkisz D, Berny U, Szprynger K, Szczepanska M (2005) Serum VCAM-1, ICAM-1, and L-selectin levels in children and young adults with chronic renal failure. Pediatr Nephrol 20:52–55

    PubMed  Google Scholar 

  122. Tan JC, Rabkin R (2005) Suppressors of cytokine signaling in health and disease. Pediatr Nephrol 20:567–575

    PubMed  Google Scholar 

  123. Zachwieja J, Zaniew M, Bobkowski W, Stefaniak E, Warzywoda A, Ostalska-Nowicka D, Dobrowolska-Zachwieja A, Lewandowska-Stachowiak M, Siwinska A (2005) Beneficial in vitro effect of N-acetyl-cysteine on oxidative stress and apoptosis. Pediatr Nephrol 20:725–731

    PubMed  Google Scholar 

  124. www.nationalchildrensstudy.gov (National Children’s Study)

  125. Lucke T, Marwedel KM, Kanzelmeyer NK, Hori A, Offner G, Kreipe HH, Ehrich JH, Das AM (2004) Generalized atherosclerosis sparing the transplanted kidney in Schimke disease. Pediatr Nephrol 19:672–675

    PubMed  Google Scholar 

  126. Stein R, Wiesner C, Beetz R, Schwarz M, Thuroff JW (2005) Urinary diversion in children and adolescents with neurogenic bladder: the Mainz experience. Part III: Colonic conduit. Pediatr Nephrol 20:932–936

    PubMed  Google Scholar 

  127. Stein R, Wiesner C, Beetz R, Schwarz M, Thuroff JW (2005) Urinary diversion in children and adolescents with neurogenic bladder: the Mainz experience. Part I: Bladder augmentation and bladder substitution--therapeutic algorisms. Pediatr Nephrol 20:920–925

    PubMed  Google Scholar 

  128. Barlow WE, Ichikawa L, Rosner D, Izumi S (1999) Analysis of case-cohort designs. J Clin Epidemiol 52:1165–1172

    CAS  PubMed  Google Scholar 

  129. Therneau TM, Li H (1999) Computing the Cox model for case cohort designs. Lifetime Data Anal 5:99–112

    CAS  PubMed  Google Scholar 

  130. Gulati S, Kumar A, Sharma RK, Gupta A, Bhandari M, Kumar A, Srivastava A (2004) Outcome of pediatric renal transplants in a developing country. Pediatr Nephrol 19:96–100

    PubMed  Google Scholar 

  131. Verrina E, Edefonti A, Gianoglio B, Rinaldi S, Sorino P, Zacchello G, Lavoratti G, Maringhini S, Pecoraro C, Calevo MG, Turrini Dertenois L, Perfumo F (2004) A multicenter experience on patient and technique survival in children on chronic dialysis. Pediatr Nephrol 19:82–90

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, TN, 38103-4909, USA

    Russell W. Chesney

  2. Pediatric Renal Service, MC 3-2482, Texas Children’s Hospital, 6621 Fannin Street, Houston, TX, 77030-2399, USA

    Eileen Brewer

  3. NIH, NIDDK, DKUH, 6707 Democracy Blvd, Two Democracy Plaza, Room 639, Bethesda, MD, 20892, USA

    Marva Moxey-Mims

  4. Division of Nephrology, Children’s Hospital and Medical Center, P.O. Box C-5371, Seattle, WA, 98105, USA

    Sandra Watkins

  5. 600 N. Wolfe Street, Park 327, Baltimore, MD, 21287-2535, USA

    Susan L. Furth

  6. Children’s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA

    William E. Harmon

  7. Department of Pediatrics, Children’s Medical Center, State University of New York at Stony Brook, Stony Brook, NY, 11794-8111, USA

    Richard N. Fine

  8. Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, 349 MacNider Hall, CB#7155, Chapel Hill, NC, 27516-7155, USA

    Debbie Gipson

  9. Pediatric Nephrology and Hypertension, University of Texas, 6431 Fannin St., Houston, TX, 77030, USA

    Ronald J. Portman

  10. The Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Bradley A. Warady

  11. Department of Pediatrics, UCLA School of Medicine, A2-383 MDCC, Le Conte Avenue, Box 951752 , Los Angeles, CA, 90095-1752, USA

    Isidro B. Salusky

  12. Northwestern University, Children’s Memorial Hospital, 2300 Children’s Plaza, Box 37, Chicago, IL, 60614, USA

    Craig B. Langman

  13. National Institute of Child Health and Human Development, Bldg 31, Room 2A32, MSC 2425, 31 Center Drive, Bethesda, MD, 20892-2425, USA

    Peter Scheidt

  14. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104-6021, USA

    Harold Feldman

  15. Department of Pediatrics, Montefiore Medical Center, 111 East 210th St, Bronx, NY, 10467, USA

    Frederick J. Kaskel

  16. Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8064, USA

    Norman J. Siegel

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  1. Russell W. Chesney
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  2. Eileen Brewer
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  3. Marva Moxey-Mims
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  4. Sandra Watkins
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  7. Richard N. Fine
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  8. Ronald J. Portman
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  13. Peter Scheidt
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  14. Harold Feldman
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  15. Frederick J. Kaskel
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  16. Norman J. Siegel
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Correspondence to Russell W. Chesney.

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Chesney, R.W., Brewer, E., Moxey-Mims, M. et al. Report of an NIH task force on research priorities in chronic kidney disease in children. Pediatr Nephrol 21, 14–25 (2006). https://doi.org/10.1007/s00467-005-2087-2

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  • DOI: https://doi.org/10.1007/s00467-005-2087-2

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