Abstract
A 5-year-old boy underwent total plasma exchange to remove anti-neuronal anti-Hu autoantibodies as a complication of neuroblastoma, leading to autonomic bowel dysfunction. Total plasma exchange (TPE) resulted eventually in a reduction of autoantibody levels, but, more importantly, led to improvement of bowel function. TPE proved to be a safe and effective treatment option in neuroblastoma-related anti-Hu syndrome in a child.
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References
Raphael JC, Chevret S, Hughes RA, Annane D (2002) Plasma exchange for Guillain-Barre syndrome. Cochrane Database Syst Rev CD 001798
Vernino S, O’Neill BP, Marks RS, O’Fallon JR, Kimmel DW (2004) Immunomodulatory treatment trial for paraneoplastic neurological disorders. Neuro-oncol 6:55–62
Graus F, Vega F, Delattre JY, Bonaventura I, Rene R, Arbaiza D, Tolosa E (1992) Plasmapheresis and antineoplastic treatment in CNS paraneoplastic syndromes with antineuronal autoantibodies. Neurology 42:536–540
Graus F, Abos J, Roquer J, Mazzara R, Pereira A (1990) Effect of plasmapheresis on serum and CSF autoantibody levels in CNS paraneoplastic syndromes. Neurology 40:1621–1623
van den Berg JS, van Engelen BG, Boerman RH, de Baets MH (1999) Acquired neuromyotonia: superiority of plasma exchange over high-dose intravenous human immunoglobulin. J Neurol 246:623–625
Yiu VWY, Kovithavongs T, McGonigle LF (2001) Plasmapheresis as an effective treatment for opsoclonus-myoclonus syndrome. Pediatr Neurol 24:72–74
RB Darnell, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349:1543–1554
Voltz R (2002) Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis, and therapy. Lancet Neurol 1:294–305
Fisher PG, Wechsler DS, Singer HS (1994) Anti-Hu antibody in a neuroblastoma-associated paraneoplastic syndrome. Pediatr Neurol 10:309–312
Mpofu C, Sztriha L, Revesz T (1996) Neuroblastoma-associated paraneoplastic syndrome with anti-Hu antineuronal antibodies presenting at the time of recurrence. Pediatr Hematol Oncol 13:369–373
Antunes NL, Khakoo Y, Matthay KK, Seeger RC, Stram DO, Gerstner E, Abrey LE, Dalmau J (2000) Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus. J Pediatr Hematol Oncol 22:315–320
Schobinger-Clement S, Gerber HA, Stallmach T (1999) Autoaggressive inflammation of the myenteric plexus resulting in intestinal pseudoobstruction. Am J Surg Pathol 23:602–606
Wildhaber B, Niggli F, Stallmach T, Willi U, Stauffer UG, Sacher P (2002) Intestinal pseudoobstruction as a paraneoplastic syndrome in ganglioneuroblastoma. Eur J Pediatr Surg 12:429–431
Wildhaber B, Niggli F, Bergstrasser E, Stallmach T, Sacher P (2003) Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea. Eur J Pediatr 162:511–513
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van Vuurden, D.G., Plötz, F.B., de Jong, M. et al. Therapeutic total plasma exchange in a child with neuroblastoma-related anti-Hu syndrome. Pediatr Nephrol 20, 1655–1656 (2005). https://doi.org/10.1007/s00467-005-2004-8
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DOI: https://doi.org/10.1007/s00467-005-2004-8