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Neonatal nephrocalcinosis in association with glucose-galactose malabsorption

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Abstract

We report a case of severe nephrocalcinosis related to hypercalcaemia in a newborn with glucose-galactose malabsorption. He presented with poor growth and was noted to have polyuria, which was later recognised to be severe watery diarrhoea. We discuss the possible aetiological factors for nephrocalcinosis in this condition.

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References

  1. Karlowicz MG, Adelman RD (1995) Renal calcification in the first year of life. Pediatr Clin North Am 42:1397–1413

    CAS  PubMed  Google Scholar 

  2. Karlowicz MG, Adelman RD (1998) What are the possible causes of neonatal nephrocalcinosis? Semin Nephrol 18:364–367

    Google Scholar 

  3. Ogilvie D, McCollum JP, Packer S, Manning J, Oyesiku J, Muller DP, Harries JT (1976) Urinary outputs of oxalate, calcium, and magnesium in children with intestinal disorders: potential cause of renal calculi. Arch Dis Child 51:790–795

    CAS  PubMed  Google Scholar 

  4. Barratt TM, Kasidas GP, Murdoch I, Rose GA (1991) Urinary oxalate and glycolate excretion and plasma oxalate concentration. Arch Dis Child 66:501–503

    CAS  PubMed  Google Scholar 

  5. Saarela T, Simila S, Kiovisto M (1995) Hypercalcaemia and nephrocalcinosis in patients with congenital lactase deficiency. J Pediatr 127:920–923

    CAS  PubMed  Google Scholar 

  6. Turk E, Zabel B, Mundlos S, Dyer J, Wright EM (1991) Glucose/galctose malabsorption caused by a defect in the Na+/glucose cotransporter. Nature 350:354–356

    CAS  PubMed  Google Scholar 

  7. Wright EM, Martín GM, Turk, E (2001) Familial glucose-galactose malabsorption and hereditary renal glycosuria. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 8th edn. Mcgraw-Hill, New York, 190:4891–4908

  8. Abdullah AMA, El-Mouzan MI, El Sheikh OK, Al Mazyad A (1996) Congenital glucose-galactose malabsorption in Arab children. J Pediatr Gastroenterol Nutr 23:561–564

    CAS  PubMed  Google Scholar 

  9. Meeuwisse GW, Melin K (1969) Glucose-galactose malabsorption: a clinical study of six cases. Acta Paediatr Scand [Suppl] 188:3–18

    Google Scholar 

  10. Abdullah AMA, Abdullah MA, Adurrahman M, Al Hussain MAS (1992) Glucose-galactose malabsorption with renal stones in a Saudi child. Ann Trop Paediatr 12:327–329

    CAS  PubMed  Google Scholar 

  11. Zeigler E, Fomon S (1983) Lactose enhances mineral absorption in infancy. J Pediatr Gastroenterol Nutr 2:288–294

    PubMed  Google Scholar 

  12. Cochet B, Jung A, Grissen M, Barthholdi P, Schaller P (1983) Effects of lactose on intestinal calcium absorption in normal and lactose-deficient subjects. Gastroenterology 84:935–940

    CAS  PubMed  Google Scholar 

  13. Bushinsky DA (2001) Acid-base imbalance and the skeleton. Eur J Nutr 40:238–244

    CAS  PubMed  Google Scholar 

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Correspondence to William G. van't Hoff.

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Pahari, A., Milla, P.J. & van't Hoff, W.G. Neonatal nephrocalcinosis in association with glucose-galactose malabsorption. Pediatr Nephrol 18, 700–702 (2003). https://doi.org/10.1007/s00467-003-1155-8

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  • DOI: https://doi.org/10.1007/s00467-003-1155-8

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