Skip to main content

Advertisement

Log in

Advanced glycation end products in children with chronic renal failure and type 1 diabetes

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract 

Serum levels of advanced glycation end products (AGEs) are markedly elevated in adults with chronic renal failure (CRF) and diabetes mellitus. Accumulation of AGEs in tissues contributes to the development of long-term complications. Up to now little has been known about the formation of AGEs in childhood. We determined serum levels of the well known AGEs pentosidine and Nɛ-carboxymethyllysine (CML) in children with CRF (n=12), end-stage renal disease (ESRD) (n=9), renal transplantation (n=12), and type 1 diabetes mellitus (n=42) and in healthy children (n=20). Pentosidine was measured by high-performance liquid chromatography (HPLC), CML by a competitive enzyme-linked immunosorbent assay (ELISA) system. Serum levels of pentosidine and CML were significantly higher in the children with CRF and ESRD than in controls (P<0.001), but nearly within the normal range after transplantation. Both AGEs showed a significant negative correlation with creatinine clearance (P<0.001). During a single session of low-flux hemodialysis, total pentosidine and CML levels did not change. Free pentosidine, however, was reduced by 78% (P=0.04). Diabe-tic children showed significantly elevated pentosidine levels (P<0.001) despite normal renal function. We conclude that, similar to adults, increased formation and accumulation of AGEs also exist in children with CRF and type 1 diabetes mellitus. At present the best prevention of AGE-related complications is an early renal transplantation in children with ESRD, as well as a careful metabolic monitoring of diabetics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 25 July 2001 / Revised: 14 November 2001 / Accepted: 18 November 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Misselwitz, J., Franke, S., Kauf, E. et al. Advanced glycation end products in children with chronic renal failure and type 1 diabetes. Pediatr Nephrol 17, 316–321 (2002). https://doi.org/10.1007/s00467-001-0815-9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-001-0815-9

Navigation