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Comparison of long-term results between laparoscopy-assisted gastrectomy and open gastrectomy with D2 lymph node dissection for advanced gastric cancer

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Abstract

Background

Laparoscopy-assisted gastrectomy (LAG) has been established as a low-invasive surgery for early gastric cancer. However, it remains unknown whether it is applicable also for advanced gastric cancer, mainly because the long-term results of LAG with D2 lymph node dissection for advanced gastric cancer have not been well validated compared with open gastrectomy (OG).

Methods

A retrospective cohort study was performed to compare LAG and OG with D2 lymph node dissection. For this study, 167 patients (66 LAG and 101 OG patients) who underwent gastrectomy with D2 lymph node dissection for advanced gastric cancer were reviewed. Recurrence-free survival and overall survival time were estimated using Kaplan–Meier curves. Stratified log-rank statistical evaluation was used to compare the difference between the LAG and OG groups stratified by histologic type, pathologic T status, N status, and postoperative adjuvant chemotherapy. The adjusted Cox proportional hazards regression models were used to calculate the hazard ratios (HRs) of LAG.

Results

The 5-year recurrence-free survival rate was 89.6% in the LAG group and 75.8% in the OG group (nonsignificant difference; stratified log-rank statistic, 3.11; P = 0.0777). The adjusted HR of recurrence for LAG compared with OG was 0.389 [95% confidence interval (CI) 0.131–1.151]. The 5-year overall survival rate was 94.4% in the LAG group and 78.5% in the OG group (nonsignificant difference; stratified log-rank statistic, 0.4817; P = 0.4877). The adjusted HR of death for LAG compared with OG was 0.633 (95% CI 0.172–2.325).

Conclusions

The findings show that LAG with D2 lymph node dissection is acceptable in terms of long-term results for advanced gastric cancer cases and may be applicable for advanced gastric cancer treatment.

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Acknowledgment

We thank Toshimitsu Hamasaki, Associate Professor in the Department of Biomedical Statistics at Osaka University Graduate School of Medicine, who gave statistical advice for this article.

Disclosures

Toshirou Nishida has a grant from the Novartis Pharma K. K. for basic research investigating gastrointestinal stromal tumor (GIST). Atsushi Hamabe, Takeshi Omori, and Koji Tanaka have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, Osaka Police Hospital, 10-31, Kitayama-cho, Tennoji-ku, Osaka, 543-0035, Japan

    Atsushi Hamabe, Takeshi Omori, Koji Tanaka & Toshirou Nishida

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  1. Atsushi Hamabe
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  2. Takeshi Omori
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  3. Koji Tanaka
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  4. Toshirou Nishida
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Correspondence to Atsushi Hamabe.

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Hamabe, A., Omori, T., Tanaka, K. et al. Comparison of long-term results between laparoscopy-assisted gastrectomy and open gastrectomy with D2 lymph node dissection for advanced gastric cancer. Surg Endosc 26, 1702–1709 (2012). https://doi.org/10.1007/s00464-011-2096-0

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