Skip to main content

Advertisement

SpringerLink
Log in

UV photolysis for relieved inhibition of sulfadiazine (SD) to biomass growth

  • Original Paper
  • Published:
Bioprocess and Biosystems Engineering Aims and scope Submit manuscript

Abstract

UV photolysis was used to relieve inhibition of biomass growth by sulfadiazine (SD), a broad-spectrum anti-microbial. To investigate the effects of SD on biomass growth, three substrates—glucose alone (G), glucose plus sulfadiazine (G+SD), and glucose plus photolyzed SD (G+PSD)—were used to culture the bacteria acclimated to glucose. The biomass was strongly inhibited when SD was added into the glucose solution, but inhibition was relieved to a significant degree when the SD was treated with UV irradiation as a pretreatment. The biomass growth kinetics were described well by the Monod model when glucose was used as a substrate alone, but the kinetics followed a hybrid Aiba model for non-competitive inhibition when SD was added to the solution. When photolyzed SD was added to glucose solution to replace original SD, the growth still followed Aiba inhibition, but inhibition was significantly relieved: the maximum specific growth rate (μ max) increased by 17 %, and the Aiba inhibition concentration increased by 60 %. Aniline, a major product of UV photolysis, supported the growth of the glucose-biodegrading bacteria. Thus, UV photolysis of SD significantly relieved inhibition by lowering the SD concentration and by generating a biodegradable product.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Sukul P, Spiteller M (2006) Sulfonamides in the environment as veterinary drugs. Rev Environ Contam Toxicol 187:67–101

    CAS  Google Scholar 

  2. Baran W, Sochacka J, Wardas W (2006) Toxicity and biodegradability of sulfonamides and products of their photocatalytic degradation in aqueous solutions. Chemosphere 65:1295–1299

    Article  CAS  Google Scholar 

  3. Sarmah AK, Meyer MT, Boxall A (2006) A global perspective on the uses, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs)in the environment. Chemosphere 65:725–759

    Article  CAS  Google Scholar 

  4. Zeng H, Wang Y (2012) The present situation and countermeasures of overuse of antibiotics. China Public Health Manag 5:341–343 (In Chinese)

    Google Scholar 

  5. Miao XS, Koenig BG, Metcalfe CD (2002) Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr A 952:139–147

    Article  CAS  Google Scholar 

  6. Castiglioni S, Fanelli R, Calamari D, Bagnati R, Zuccato E (2004) Methodological approaches for studying pharmaceuticals in the environment by comparing predicted and measured concentrations in River Po, Italy. Regul Toxicol Pharmacol 39:25–32

    Article  CAS  Google Scholar 

  7. Xu WH, Zhang G, Zou SC, Li XD, Li P, Hu ZH, Li J (2007) Occurrence, distribution and fate of antibiotics in sewage treatment plants. Environ Sci 28:1779–1783 (In Chinese)

    CAS  Google Scholar 

  8. Göbel A, McArdell CS, Joss A, Siegrist H, Giger W (2007) Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Sci Total Environ 372:361–371

    Article  Google Scholar 

  9. Chang H, Hu JY, Wang LZ, Shao B (2008) Occurrence of sulfonamide antibiotics in sewage treatment plants. Chin Sci Bull 53:159–164

    Google Scholar 

  10. Li J, Wang J, Xie M (2013) Screening and evaluation on bioassays of antibiotic pollutants toxicity on activated sludge. Chin J Environ Eng 7:1989–1995 (In Chinese)

    CAS  Google Scholar 

  11. García Galán MJ, Díaz-Cruz MS, Barceló D (2012) Removal of sulfonamide antibiotics upon conventional activated sludge and advanced membrane bioreactor treatment. Anal Bioanal Chem 404:1505–1515

    Article  Google Scholar 

  12. Den W, Ravindran V, Pirbazari M (2006) Photooxidation and biotrickling filtration for controlling industrial emissions of trichloroethylene and perchloroethylene. Chem Eng Sci 61:7909–7923

    Article  CAS  Google Scholar 

  13. Pan S, Yan N, Liu X, Wang W, Zhang Y, Liu R, Rittmann EB (2014) How UV photolysis accelerates the biodegradation and mineralization of sulfadiazine (SD). Biodegradation 25:911–921

    Article  CAS  Google Scholar 

  14. von Stosch M, Oliveria R, Peres J (2012) Hybrid modeling framework for process analytical technology: application to Bordetella pertussis cultures. Biotechnol Prog 28:284–291

    Article  Google Scholar 

  15. Wan M, Wang R, Xia J (2012) Physiological evaluation of a new Chlorella sorokiniana isolate for its biomass production and lipid accumulation in photoautotrophic and heterotrophic cultures. Biotechnol Bioeng 109:1958–1964

    Article  CAS  Google Scholar 

  16. Qi Y, Wang S (2007) Biological reaction kinetics and reactor, 3rd edn. Chemical Industry Press, Beijing (In Chinese)

    Google Scholar 

  17. American Public Health Association (APHA) (2001) Standard methods for the examination of water and wastewater, 22nd edn. American Water Works Association and Water Pollution Control Federation, Washington DC, USA

    Google Scholar 

  18. Aiba S, Shoda M, Nagalani M (2000) Kinetics of product inhibition in alcohol fermentation. Biotechnol Bioeng 67:671–690

    Article  CAS  Google Scholar 

  19. Tappe W, Herbst M, Hofmann D, Koeppchen S, Kummer S, Thiele B, Groeneweg J (2013) Degradation of sulfadiazine by Microbacterium lacus strain SDZm4, isolated from lysi-meters previously manured with slurry from sulfadiazine medicated pigs. Appl Environ Microbiol 79:2572–2577

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors acknowledge the financial support by the National Natural Science Foundation of China (50978164), Key project of basic research in Shanghai (11JC1409100), the Special Foundation of Chinese Colleges and Universities Doctoral Discipline (20113127110002), Special Fund of State Key Joint Laboratory of Environment Simulation and Pollution Control (13K09ESPCT), and the United States National Science Foundation (0651794).

Author information

Authors and Affiliations

  1. Department of Environmental Science and Engineering, School of Life and Environmental Science, Shanghai Normal University, Shanghai, 200234, China

    Shihui Pan, Ning Yan & Yongming Zhang

  2. Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ, 85287-5701, USA

    Bruce E. Rittmann

Authors
  1. Shihui Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ning Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yongming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bruce E. Rittmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yongming Zhang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pan, S., Yan, N., Zhang, Y. et al. UV photolysis for relieved inhibition of sulfadiazine (SD) to biomass growth. Bioprocess Biosyst Eng 38, 911–915 (2015). https://doi.org/10.1007/s00449-014-1335-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00449-014-1335-x

Keywords

Search

Navigation