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GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system

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Abstract. 

To improve the quality of cytoplasmic labelling of GAL4-expressing cells in Drosophila enhancer-trap and transgenic strains, a new GAL4-responsive reporter UAS-tau, which features a bovine tau cDNA under control of a yeast upstream activation sequence (UAS), was tested. Tau, a microtubule-associated protein, is distributed actively and evenly into all cellular processes. Monoclonal anti-bovine Tau antibody reveals the axonal structure of the labelled cells with detail similar to that of Golgi impregnation. We demonstrate that the UAS-tau system is especially useful for studying processes of differentiation and reorganisation of identified neurones during postembryonic development.

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Authors and Affiliations

  1. Institut für Genetik, Universität Mainz, Saarstr. 21, D-55122 Mainz, Germany, , , , , , DE

    Kei Ito, Heinz Sass & Joachim Urban

  2. Lehrstuhl für Biologie VI, Institut für Zoologie, Universität Regensburg, Universitätsstr. 31, D-93040 Regensburg, Germany, , , , , , DE

    Alois Hofbauer & Stephan Schneuwly

Authors
  1. Kei Ito
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  2. Heinz Sass
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  3. Joachim Urban
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  4. Alois Hofbauer
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  5. Stephan Schneuwly
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Received: 28 February 1997 / Accepted: 10 May 1997

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Ito, K., Sass, H., Urban, J. et al. GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system. Cell Tissue Res 290, 1–10 (1997). https://doi.org/10.1007/s004410050901

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  • DOI: https://doi.org/10.1007/s004410050901

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