Skip to main content

Advertisement

SpringerLink
Log in

Synthesis and localization of the mucin-associated TFF-peptides in the human uterus

  • Regular article
  • Published:
Cell and Tissue Research Aims and scope Submit manuscript

Abstract.

TFF-peptides (formerly P-domain peptides, trefoil factors) are typical secretory products of mucin-producing cells and are thought to influence the rheological properties of mucous gels. Here, the localization of these peptides in the human uterus was investigated. An analysis of TFF-peptides mRNA by the polymerase chain reaction revealed TFF3 mainly in the endocervix and smaller amounts in the endometrium. TFF1 and TFF2 mRNA was detectable occasionally in the endocervix and very rarely in the endometrium. Western blot analysis detected only TFF3 in tissue extracts of the endocervix and as a constituent of human cervical mucus. Immunofluorescence localized TFF3 in the surface epithelium of the endocervix and in gland-like structures of the cervical epithelium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Institut für Molekularbiologie und Medizinische Chemie, Universitätsklinikum, Otto-von-Guericke-Universität, Leipziger Str. 44, 39120 Magdeburg, Germany, , , , ,

    Antje Wiede, Margitta Hinz & Werner Hoffmann

  2. Klinik für Gynäkologie und Geburtshilfe, Städtisches Klinikum, 39130 Magdeburg, Germany, , , , ,

    Eberhard Canzler

  3. Universitätsfrauenklinik, Otto-von-Guericke-Universität, 39120 Magdeburg, Germany, , , , ,

    Kornelia Franke

  4. Institut für Pathologie, Städtisches Klinikum, 39104 Magdeburg, Germany, , , , ,

    Claudia Quednow

Authors
  1. Antje Wiede
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margitta Hinz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eberhard Canzler
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kornelia Franke
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Claudia Quednow
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Werner Hoffmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wiede, A., Hinz, M., Canzler, E. et al. Synthesis and localization of the mucin-associated TFF-peptides in the human uterus. Cell Tissue Res 303, 109–115 (2001). https://doi.org/10.1007/s004410000297

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004410000297

Search

Navigation