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Novel therapeutic approaches of tissue engineering in male infertility

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Abstract

Male reproductive organ plays an important role in sperm production, maintenance and entry to the female reproductive tract, as well as generation and secretion of male sex hormones responsible for the health of male reproductive system. The purpose of this paper is to discuss the experimental and clinical evidence on the utilization of tissue engineering techniques in treating male infertility. Tissue engineering (TE) and regenerative medicine have developed new approaches to treat patients with reproductive disorders such as iatrogenic injuries, congenital abnormalities, and trauma. In some cases, including congenital defects and undescended testis or hypogonadism, the sperm samples are not retrieved. This makes TE a possible future strategy for restoration of male fertility. Here, we have summarized the recent advances in experimental and clinical application of cell-, tissue-, and organ-based regenerative medicine in male reproductive disorders.

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Abbreviations

TE:

Tissue engineering

ECM:

Extracellular matrix

iPSCs:

induced pluripotent stem cells

ESCs:

Embryonic stem cells

MSCs:

Mesenchymal stem cells

GFs:

Growth factors

ART:

Assisted reproductive techniques

VEGF:

Vascular endothelial growth factor

BMP:

Bone morphogenetic protein

TGF:

Transforming growth factor

hESC:

Human embryonic stem cells

SSCs:

Spermatogonia stem cells

2D:

2-dimensional

3D:

3-dimensional

IVF :

in vitro fertilization

ICSI:

Intracytoplasmic sperm injection

SCNT:

Somatic cell nuclear transfer

PGCs:

Primordial germ cells

CBVD:

Congenital bilateral vas deferens

SMC:

Smooth muscle cells

TDSs:

Testis-derived scaffolds

TOs:

Testicular organoids

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Acknowledgments

This study was supported by stem cell research center at Tabriz University of Medical Sciences, Iran.

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Authors and Affiliations

  1. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Elham Ghanbari

  2. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mozafar Khazaei

  3. Department of Tissue Engineering, Tabriz University of Medical Sciences, Tabriz, Iran

    Maryam Ghahremani-nasab

  4. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Mehdizadeh

  5. Comprehensive Health Laboratory, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Mehdizadeh

  6. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mehdi Yousefi

  7. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

    Mehdi Yousefi

  8. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Mehdi Yousefi

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  1. Elham Ghanbari
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  2. Mozafar Khazaei
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  3. Maryam Ghahremani-nasab
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Correspondence to Mehdi Yousefi.

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Ghanbari, E., Khazaei, M., Ghahremani-nasab, M. et al. Novel therapeutic approaches of tissue engineering in male infertility. Cell Tissue Res 380, 31–42 (2020). https://doi.org/10.1007/s00441-020-03178-w

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