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Neuropeptidergic modulation of GnRH neuronal activity and GnRH secretion controlling reproduction: insights from recent mouse studies

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Abstract

Gonadotropin-releasing hormone (GnRH) secretion from GnRH neurons and its modulation by neuropeptides are essential for mammalian reproduction. Here, I review the neuropeptides that have been shown to act directly and that may also act indirectly, on GnRH neurons, the reproduction-related processes with which the neuropeptides may be associated or the physiological information they may convey, as well as their cognate receptors, signaling pathways and roles in the modulation of GnRH neuronal firing, [Ca2+]i, GnRH secretion and reproduction. The review focuses on recent research in mice, which offer the most tractable experimental system for studying mammalian GnRH neurons.

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Acknowledgments

This article is dedicated to the memory of Prof. Peter H. Seeburg (1944–2016).

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  1. Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St., FMB 415, New Haven, CT, 06520, USA

    Daniel J. Spergel

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Spergel, D.J. Neuropeptidergic modulation of GnRH neuronal activity and GnRH secretion controlling reproduction: insights from recent mouse studies. Cell Tissue Res 375, 179–191 (2019). https://doi.org/10.1007/s00441-018-2893-z

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