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P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies

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Abstract

To explore the real association between p53 codon 72 polymorphism and lung cancer risk, a pooled analysis of 32 case–control studies involving 19,255 subjects was conducted. When all 32 studies were pooled into the analysis, significantly elevated lung cancer risks were associated with variant genotypes in all genetic models (for Pro/Arg vs. Arg/Arg: OR 1.21, 95% CI 1.01–1.23; for Pro/Pro vs. Arg/Arg: OR 1.20, 95% CI 1.03–1.39; for Pro/Pro + Pro/Arg vs. Arg/Arg: OR 1.14, 95% CI 1.03–1.25; for Pro/Pro vs. Arg/Arg + Pro/Arg: OR 1.06, 95% CI 1.01–1.12). In the subgroup analysis by ethnicity, histological type, or smoking status, significantly increased risks were found in subgroups such as Asians, Caucasians, lung adenocarcinoma patients, or smokers, respectively. In conclusion, our results suggest that the Pro allele at p53 codon 72 is emerging as a low-penetrance susceptibility allele for lung cancer development.

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Acknowledgments

This work was supported by grants from “Nature Science Foundation of Liuzhou, Guangxi, PR China” (20050336).

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Authors and Affiliations

  1. Department of Lab, The Fourth Hospital Affiliated to Guangxi Medical University, Liuzhou, China

    Shengming Dai, Lijun Jiang, Guisheng Wang & Hongge Cheng

  2. Department of Oncology, The Fourth Hospital Affiliated to Guangxi Medical University, Liuzhou, China

    Shengming Dai

  3. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Chen Mao

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  1. Shengming Dai
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  2. Chen Mao
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  3. Lijun Jiang
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  4. Guisheng Wang
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  5. Hongge Cheng
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Correspondence to Shengming Dai.

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S. Dai, C. Mao and L. Jiang contributed equally to this work and should be considered as co-first authors.

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Dai, S., Mao, C., Jiang, L. et al. P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case–control studies. Hum Genet 125, 633–638 (2009). https://doi.org/10.1007/s00439-009-0664-3

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  • DOI: https://doi.org/10.1007/s00439-009-0664-3

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