Abstract
In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
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Acknowledgments
The authors thank the Electron Microscopy Unit of CINVESTAV for all the facilities. This investigation was supported by grants SIP2010726, SIP20110886, SIP20121394, SIP20130645, CONACyT 167376, and ICyTDF scholarships granted to Pérez-Rangel and Castillo-Romero.
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Pérez-Rangel, A., Hernández, J.M., Castillo-Romero, A. et al. Albendazole and its derivative JVG9 induce encystation on Giardia intestinalis trophozoites. Parasitol Res 112, 3251–3257 (2013). https://doi.org/10.1007/s00436-013-3521-1
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DOI: https://doi.org/10.1007/s00436-013-3521-1