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Metabolites from the leaf extract of Serjania yucatanensis with trypanocidal activity against Trypanosoma cruzi

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Abstract

The bioassay-guided phytochemical investigation of the leaf extract of Serjania yucatanensis, a woody climbing plant endemic to the Yucatan peninsula, led to the identification of a mixture of a triterpene [lup-20(29)-en-3-one] and an oxygenated sesquiterpene (β-caryophyllene oxide), as that responsible for the originally detected trypanocidal activity in the organic crude extract. Results showed that the mixture of lup-20(29)-en-3-one and β-caryophyllene oxide is active against trypomastigotes of Trypanosoma cruzi (IC50 = 80.3 μg/mL) and inhibits the egress of trypomastigotes from infected Vero cells (when tested at 100 μg/mL) without being cytotoxic.

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Acknowledgments

The authors wish to thank Paulino Cimá for technical assistance and the identification of the plant material. GPH acknowledges the support of Consejo Nacional de Ciencia y Tecnología (CONACYT), through its “Becas Mixtas” Program, to carry out a research stay at the University of Antofagasta. This work was supported by Project FOMIX-Yucatán (66262) and Programa de Cooperación Bilateral México-Chile.

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Authors and Affiliations

  1. Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida, Yucatán, 97200, Mexico

    Glendy Polanco-Hernández, Fabiola Escalante-Erosa, Karlina García-Sosa & Luis M. Peña-Rodríguez

  2. Departamento de Microbiología Ambiental y Biotecnología, Universidad Autónoma de Campeche, Campeche, Mexico

    Manuel J. Chan-Bacab

  3. Unidad de Parasitología, Universidad de Antofagasta, Antofagasta, Chile

    Hernán Sagua-Franco, Jorge González & Luis Osorio-Rodríguez

Authors
  1. Glendy Polanco-Hernández
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  2. Fabiola Escalante-Erosa
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  3. Karlina García-Sosa
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  4. Manuel J. Chan-Bacab
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  5. Hernán Sagua-Franco
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  6. Jorge González
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  7. Luis Osorio-Rodríguez
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  8. Luis M. Peña-Rodríguez
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Corresponding author

Correspondence to Luis M. Peña-Rodríguez.

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Polanco-Hernández, G., Escalante-Erosa, F., García-Sosa, K. et al. Metabolites from the leaf extract of Serjania yucatanensis with trypanocidal activity against Trypanosoma cruzi . Parasitol Res 111, 451–455 (2012). https://doi.org/10.1007/s00436-012-2861-6

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  • DOI: https://doi.org/10.1007/s00436-012-2861-6

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