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Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves

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Abstract

The crude methanolic extract from leaves of Jacaranda puberula showed activity against Leishmania (Leishmania) amazonensis. The extract presented active against promastigote forms with an inhibitory concentration 50% (IC50) value of 88.0 μg/ml, but only moderated activity against amastigote forms; however in higher concentrations the extract showed cytotoxic effects. The bio-guided chromatographic fractionation the crude methanolic extract against amastigotes yielded a fraction with an IC50 value of 14.0 μg/ml (without cytotoxic activity) in relation to the crude extract (IC50 value, 359.0 μg/ml). These data indicate that J. puberula leaves contain active compounds, which should be further investigated for the development of new potential drugs against cutaneous leishmaniasis.

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Authors and Affiliations

  1. Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo (USP), Av. Dr. Arnaldo 455, Cerqueira César, São Paulo, 0146-903, SP, Brazil

    L. F. D. Passero, A. A. Castro, T. Y. Tomokane, C. E. P. Corbett & M. D. Laurenti

  2. Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo (USP), Av. Prof. Lineu Prestes 748, Butantã, São Paulo, 05508-000, SP, Brazil

    M. J. Kato & T. F. Paulinetti

Authors
  1. L. F. D. Passero
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  2. A. A. Castro
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  3. T. Y. Tomokane
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  4. M. J. Kato
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  5. T. F. Paulinetti
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  6. C. E. P. Corbett
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  7. M. D. Laurenti
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Correspondence to L. F. D. Passero.

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Passero, L.F.D., Castro, A.A., Tomokane, T.Y. et al. Anti-leishmania activity of semi-purified fraction of Jacaranda puberula leaves. Parasitol Res 101, 677–680 (2007). https://doi.org/10.1007/s00436-007-0530-y

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  • DOI: https://doi.org/10.1007/s00436-007-0530-y

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