Skip to main content
SpringerLink
Log in

Endometrial cancer subtypes are associated with different patterns of recurrence

  • Original Article – Clinical Oncology
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the pattern of endometrial cancer recurrence according to its biological subtype in a large cohort of patients.

Patients and methods

Patients were stage eligible if they had a description of registry risk of recurrence status and were not primary metastatic. Data were prospectively collected. The primary endpoints were the subtype-dependent pattern and time of recurrence.

Results

The median follow-up time was 84 months. The highest 10-year recurrence-free and overall survival were seen in the group of patients at low risk of recurrence, 83.1 and 94.1%, respectively. The 10-year recurrence-free survival for intermediate and high risk group was 65.7 and 56.2%, respectively, whereas the estimated 10-year overall survival for both groups was 84.5 and 79.3%, respectively. Patients at high risk demonstrated the highest levels of disease recurrence in the first 3–4 years after diagnosis and the most common site of metastasis was the lung. In contrast, the rate of recurrence for patients at intermediate and low risk of recurrence in the first 5 years was relatively low but remained continuous up to 10 years of follow-up. Overall, the most common site of relapse was local recurrence.

Conclusion

Endometrial cancer subtypes are associated with different times and patterns of recurrence and this should be considered when determining the treatment strategy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Bendifallah S, Ouldamer L, Lavoue V, Canlorbe G, Raimond E, Coutant C et al (2017) Patterns of recurrence and outcomes in surgically treated women with endometrial cancer according to ESMO-ESGO-ESTRO consensus conference risk groups: results from the FRANCOGYN study group. Gynecol Oncol 144:107–112

    Article  Google Scholar 

  • Colombo N, Preti E, Landoni F, Carinelli S, Colombo A, Marini C et al (2011) Endometrial cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 22(Suppl 6):vi35–9

    PubMed  Google Scholar 

  • Eggemann H, Ignatov T, Burger E, Costa SD, Ignatov A (2017) Management of elderly women with endometrial cancer. Gynecol Oncol 146:519–524

    Article  Google Scholar 

  • Fung-Kee-Fung M, Dodge J, Elit L, Lukka H, Chambers A, Oliver T et al (2006) Follow-up after primary therapy for endometrial cancer: a systematic review. Gynecol Oncol 101:520–529

    Article  Google Scholar 

  • Kurra V, Krajewski KM, Jagannathan J, Giardino A, Berlin S, Ramaiya N (2013) Typical and atypical metastatic sites of recurrent endometrial carcinoma. Cancer Imaging 13:113–122

    Article  Google Scholar 

  • Mariani A, Webb MJ, Keeney GL, Calori G, Podratz KC (2001) Hematogenous dissemination in corpus cancer. Gynecol Oncol 80:233–238

    Article  CAS  Google Scholar 

  • Piura E, Piura B (2012) Brain metastases from endometrial carcinoma. ISRN Oncol 2012:581749

    PubMed  PubMed Central  Google Scholar 

  • Salani R, Khanna N, Frimer M, Bristow RE, Chen LM (2017) An update on post-treatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncology (SGO) recommendations. Gynecol Oncol 146:3–10

    Article  Google Scholar 

  • Sohaib SA, Houghton SL, Meroni R, Rockall AG, Blake P, Reznek RH (2007) Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis. Clin Radiol 62:28–34 (discussion 5–6)

    Article  CAS  Google Scholar 

  • Uccella S, Morris JM, Bakkum-Gamez JN, Keeney GL, Podratz KC, Mariani A (2013) Bone metastases in endometrial cancer: report on 19 patients and review of the medical literature. Gynecol Oncol 130:474–482

    Article  Google Scholar 

  • von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370:1453–1457

    Article  Google Scholar 

Download references

Funding

This study was not funded.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Otto-von-Guericke University, G.-Hauptmann Str. 35, 39108, Magdeburg, Germany

    Tanja Ignatov, Holm Eggemann, Serban Dan Costa & Atanas Ignatov

  2. Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany

    Olaf Ortmann & Atanas Ignatov

Authors
  1. Tanja Ignatov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Holm Eggemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Serban Dan Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Olaf Ortmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atanas Ignatov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Atanas Ignatov.

Ethics declarations

Conflict of interest

All authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study before treatment. According to the statement of Research and Ethical Committee, Otto-von-Guericke University, Magdeburg, Germany, an additional individual consent was not required for this analysis. Before analysis, patient data underwent a pesudonymisation.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ignatov, T., Eggemann, H., Costa, S.D. et al. Endometrial cancer subtypes are associated with different patterns of recurrence. J Cancer Res Clin Oncol 144, 2011–2017 (2018). https://doi.org/10.1007/s00432-018-2711-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00432-018-2711-8

Keywords

Search

Navigation