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Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Objectives

A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from radio-resistant histology groups.

Methods

The primary end point was local control (LC), secondary end points were overall survival (OS) and progression free survival (PFS). Toxicity was scored according to CTCAE 4.03.

Results

200 patients were analyzed: 49.5% of the cases derived from colorectal primary tumors, 20.5% from sarcomas, 12.0% from renal cell carcinoma and the rest from other mixed origin. The mean follow-up was 24.2 months. LC at 1 and 2 years was 91, 84.9%. Primary histology and the presence of extra-pulmonary disease had a significant impact on LC. OS at 1 and 2 years was 88.7, 65.4%. Primary histology, disease free interval, presence of extra-pulmonary disease, number of irradiated lung lesions and age showed a correlation with prognosis at univariate analysis. PFS at 1 and 2 years was 84, 57.7%. The presence of extra-pulmonary disease and the number of irradiated lung lesions correlated with prognosis. Treatment was well tolerated with no G3–4 acute or late toxicity recorded.

Conclusion

Colorectal metastases showed a higher rate of local relapse. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions.

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Authors and Affiliations

  1. Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy

    Davide Franceschini, Luca Cozzi, Fiorenza De Rose, Piera Navarria, Ciro Franzese, Tiziana Comito, Cristina Iftode, Angelo Tozzi, Lucia Di Brina, Anna Maria Ascolese, Elena Clerici, Giuseppe D’Agostino, Antonella Fogliata & Marta Scorsetti

  2. Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy

    Luca Cozzi & Marta Scorsetti

Authors
  1. Davide Franceschini
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  2. Luca Cozzi
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  3. Fiorenza De Rose
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  4. Piera Navarria
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  5. Ciro Franzese
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  6. Tiziana Comito
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  7. Cristina Iftode
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  8. Angelo Tozzi
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  9. Lucia Di Brina
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  10. Anna Maria Ascolese
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  13. Antonella Fogliata
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  14. Marta Scorsetti
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Corresponding author

Correspondence to Davide Franceschini.

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Funding

No funding or financial interests for this study.

Conflict of interest

L. Cozzi acts as Scientific Advisor to Varian Medical Systems and is Clinical Research Scientist at Humanitas Cancer Center. All other co-authors declare that they have no conflict interests.

Ethical approval

For this type of study formal consent is not required. However, all procedures were in accordance with the ethical standards and the Helsinki declaration.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Franceschini, D., Cozzi, L., De Rose, F. et al. Role of stereotactic body radiation therapy for lung metastases from radio-resistant primary tumours. J Cancer Res Clin Oncol 143, 1293–1299 (2017). https://doi.org/10.1007/s00432-017-2373-y

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  • DOI: https://doi.org/10.1007/s00432-017-2373-y

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