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CT-guided implantation of radioactive 125I seed in advanced non-small-cell lung cancer after failure of first-line chemotherapy

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

We investigated implanting computed tomography (CT)-guided 125I seed to treat locally advanced non-small-cell lung cancer (NSCLC) after chemotherapy failure.

Methods

From January 2005 to July 2010, we recruited 69 patients with locally advanced NSCLC who had each had first-line chemotherapy four to six times but had progressive disease; 34 received 125I seed implantation with second-line chemotherapy (Group A) and 35 received second-line chemotherapy only (Group B).

Results

Mean follow-up was 32 months (range 5–56 months). Overall 2-year local control rate for existing lung lesions was Group A: 39.9 %; Group B: 12.5 % (P < 0.05). The 1-, 3-year, and median overall survival was 68.7 and 20.8 % at 17.4 months in Group A; and 45.1 and 18.7 % at 11.3 months in Group B, respectively (P > 0.05). Local 3-, 24-month, and median progression-free survival was Group A: 100 and 79.1 % at 11 months; Group B: 76.5 and 18.7 % at 7.3 months, respectively. The groups did not significantly differ in treatment toxicity. Chest pain remission was Group A: 82.1 % (23/28); Group B: 30.8 % (8/26) (P < 0.05). Group A showed no radiation-related pneumonia, esophagitis, bronchial fistulae, or life-threatening morbidity.

Conclusion

CT-guided radioactive seed 125I implantation procedure is safe and well tolerated in treating locally advanced NSCLC, with few complications. It has good local control rate and can relieve symptoms without increasing side effects.

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Acknowledgments

This work was supported by the Provincial and Ministry of education Research Project of Guangdong (Grant No. 2012B091100458 to Fujun Zhang) and Major project of science and technology of Guangzhou (Grant No. 132400027 to Fujun Zhang), and national natural science foundation of China (Grant No. 81371654 to Fujun Zhang).

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, 651 Dongfeng Road, East, Guangzhou, 510060, People’s Republic of China

    Tao Zhang, Mingjian Lu, Sheng Peng, Weidong Zhang, Guang Yang, Zhenyin Liu, Sristi Singh, Yadi Yang, Fujun Zhang & Fei Gao

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  1. Tao Zhang
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  2. Mingjian Lu
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  3. Sheng Peng
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  4. Weidong Zhang
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  5. Guang Yang
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  6. Zhenyin Liu
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  7. Sristi Singh
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  8. Yadi Yang
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  9. Fujun Zhang
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  10. Fei Gao
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Correspondence to Fujun Zhang or Fei Gao.

Additional information

Tao Zhang and Mingjian Lu have contributed equally to this article.

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Zhang, T., Lu, M., Peng, S. et al. CT-guided implantation of radioactive 125I seed in advanced non-small-cell lung cancer after failure of first-line chemotherapy. J Cancer Res Clin Oncol 140, 1383–1390 (2014). https://doi.org/10.1007/s00432-014-1655-x

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