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Treatment outcome of patients with liver-only metastases from breast cancer after mastectomy: a retrospective analysis

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Abstract

Purpose

To evaluate the efficiency of combined treatment of transcatheter arterial chemoembolization (TACE) and systemic chemotherapy (SC) for liver-only metastases from breast cancer after mastectomy.

Methods

We compared the outcomes of 44 patients who underwent combined treatment of TACE and systemic chemotherapy (TSC) with those of 43 patients who underwent systemic chemotherapy (SC).

Results

The median follow-up from the diagnosis of liver metastases was 29 months (range, 0-89 months). Response rates were 59.1% and 34.9% for TSC group and SC group (P < 0.05), respectively. The 1-, 2- and 3-year survival rates for TSC group were 76.2, 66.7 and 47.6%, and those for SC group were 48.1, 29.6 and 7.4% (P = 0.027), respectively. Estrogen receptor (ER)-negative status of primary tumor, disease-free interval from mastectomy to liver metastases (DFI) less than 24 months and patients who received systemic chemotherapy only were independently associated with poor prognosis (P = 0.009; P = 0.023; P = 0.030).

Conclusions

The combined treatment of TACE and systemic chemotherapy may prolong survival for liver metastases in breast cancer after mastectomy.

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Acknowledgments

The study was supported by Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Huan-Hu-Xi Road, Ti-Yuan-Bei, He Xi District, Tianjin, 300060, People’s Republic of China

    Xiao Feng Duan, Na Na Dong, Ti Zhang & Qiang Li

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  1. Xiao Feng Duan
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  2. Na Na Dong
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  3. Ti Zhang
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Correspondence to Qiang Li.

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Duan, X.F., Dong, N.N., Zhang, T. et al. Treatment outcome of patients with liver-only metastases from breast cancer after mastectomy: a retrospective analysis. J Cancer Res Clin Oncol 137, 1363–1370 (2011). https://doi.org/10.1007/s00432-011-1008-y

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