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Multicentric infantile myofibromatosis: two perinatal cases

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Abstract

Infantile myofibromatosis, the most common fibrous tumor of infancy, occurs in solitary, multiple, and generalized forms, with similar histology but different clinicopathologic and prognostic implications. This entity is a mesenchymal disorder characterized by the proliferation of fibrous tumors in the skin, muscles, viscera, bones, and subcutaneous tissues. Visceral lesions are associated with significant morbidity and mortality, generally within the first few months of life. They lead to failure to thrive, to infection, hemorrhage, or to the obstruction of vital organs. We describe two cases of multicentric myofibromatosis with significant in utero lesional growth, resulting in one fetal demise and one post-natal demise. To the best of our knowledge, this is the first report of a fetal death secondary to infantile myofibromatosis.

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References

  1. Baird PA, Worth AJ (1976) Congenital generalized fibromatosis: an autosomal recessive condition? Clin Genet 9(5):488–494

    Article  PubMed  CAS  Google Scholar 

  2. Chung EB, Enzinger FM (1981) Infantile myofibromatosis. Cancer 48(8):1807–1818

    Article  PubMed  CAS  Google Scholar 

  3. Enzinger FM, Weiss SW (1983) Infantile myofibromatosis. In: Soft tissue tumors, 3rd edn. CV Mosby, St. Louis, Missouri

    Google Scholar 

  4. Gengler C, Guillou L (2006) Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histology 48(1):63–74

    CAS  Google Scholar 

  5. Jennings TA, Duray PH, Collins FS, Sabetta J, Enzinger FM (1984) Infantile myofibromatosis. Evidence for an autosomal-dominant disorder. Am J Surg Pathol 8(7):529–538

    Article  PubMed  CAS  Google Scholar 

  6. Kubota A, Imano M, Yonekura T, Hirooka S, Nose K, Oyanagi H, Nakayama M (1999) Infantile myofibromatosis of the triceps detected by prenatal sonography. J Clin Ultrasound 27(3):147–150

    Article  PubMed  CAS  Google Scholar 

  7. Meizner I, Shalev J, Mashiach R, Vardimon D, Ben-Raphael Z (2000) Prenatal ultrasound diagnosis of infantile myofibromatosis—a case report. Ultrasound Obstet Gynecol 16(1):84–86

    Article  PubMed  CAS  Google Scholar 

  8. Mentzel T, Calonje E, Nascimento AG, Fletcher CD (1994) Infantile hemangiopericytoma versus infantile myofibromatosis. Study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol 18(9):922–930

    PubMed  CAS  Google Scholar 

  9. Nishioka K, Seguchi T, Yamamura Y, Tatsumura M, Sou H, Gondo T, Hoshii Y, Iwata T (1999) Infantile myofibromatosis identified by fetal ultrasound. Br J Dermatol 140(3):539–541

    Article  PubMed  CAS  Google Scholar 

  10. Quinn SF, Erickson SJ, Dee PM, Walling A, Hackbarth DA, Knudson GJ, Moseley HS (1991) MR imaging in fibromatosis: results in 26 patients with pathologic correlation. AJR Am J Roentgenol 156(3):539–542

    PubMed  CAS  Google Scholar 

  11. Schrodt BJ, Callen JP (1999) A case of congenital multiple myofibromatosis developing in an infant. Pediatrics 104(1 Pt 1):113–115

    Article  PubMed  CAS  Google Scholar 

  12. Wiswell TE, Sakas EL, Stephenson SR, Lesica JJ, Reddoch SR (1985) Infantile myofibromatosis. Pediatrics 76(6):981–984

    PubMed  CAS  Google Scholar 

  13. Wiswell TE, Davis J, Cunningham BE, Solenberger R, Thomas PJ (1988) Infantile myofibromatosis: the most common fibrous tumor of infancy. J Pediatr Surg 23(4):315–318

    Article  PubMed  CAS  Google Scholar 

  14. Zand DJ, Huff D, Everman D, Russel K, Saitta S, McDonald-McGinn D, Zackai EH (2004) Autosomal dominant inheritance of infantile myofibromatosis. Am J Med Genet A 126(3):261–266

    Article  PubMed  Google Scholar 

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Correspondence to Fanny Pelluard-Nehmé.

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Pelluard-Nehmé, F., Coatleven, F., Carles, D. et al. Multicentric infantile myofibromatosis: two perinatal cases. Eur J Pediatr 166, 997–1001 (2007). https://doi.org/10.1007/s00431-006-0369-8

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  • DOI: https://doi.org/10.1007/s00431-006-0369-8

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