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Burkholderia pseudomallei infection in chronic granulomatous disease

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Abstract

Melioidosis is a severe illness caused by Burkholderia pseudomallei, a sepsis-causing bacterial pathogen that is common in East Asia. We reexamined the underlying diagnosis in a 12-year-old boy who was diagnosed in the French West Indies with melioidosis when he was 4 years old. Our investigations led to the determination of chronic granulomatous disease (CGD), an inherited condition characterized by phagocytic cell dysfunction. This is the third reported case of melioidosis associated with CGD to be reported, lending support to an association between the two. The molecular determinants of the susceptibility of CGD patients to B. pseudomallei are still unknown. Our report suggests that CGD should be suspected in children with melioidosis, both in the Americas and probably in other regions world-wide.

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Abbreviations

CGD:

Chronic granulomatous disease

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Acknowledgements

We would like to thank Jean-Baptiste Armengaud and all members of the Pediatric Immuno-Hematological unit who took care of the patient. We are extremely grateful to the patient and his family for their collaboration. RR thanks Julien and Brigitte Vielle and Sergio Fanconi for their support. The Laboratory of Human Genetics of Infectious Diseases is supported in part by grants from the Schlumberger and BNP Paribas Foundations, and by EU grant QLK2-CT-2002-00846.

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Authors and Affiliations

  1. Unité d’Immunologie et Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France

    Raffaele Renella, Alain Fischer, Stéphane Blanche, Jean-Laurent Casanova & Capucine Picard

  2. Laboratoire de Microbiologie, Centre Hospitalier Universitaire de Pointe-à-Pitre, Guadeloupe, France

    Jean-Marie Perez

  3. Laboratoire d’Immunologie et INSERM U479, Centre Hospitalier Universitaire Bichat “Claude Bernard”, Paris, France

    Sylvie Chollet-Martin

  4. Service de Chirurgie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France

    Sabine Sarnacki

  5. Laboratoire de Génétique Humaine des Maladies Infectieuses, INSERM Unité 550 Faculté Necker, 156, rue Vaugirard, 75015, Paris, France

    Jean-Laurent Casanova & Capucine Picard

Authors
  1. Raffaele Renella
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  2. Jean-Marie Perez
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  3. Sylvie Chollet-Martin
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  4. Sabine Sarnacki
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  5. Alain Fischer
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  6. Stéphane Blanche
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  7. Jean-Laurent Casanova
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  8. Capucine Picard
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Corresponding author

Correspondence to Capucine Picard.

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Renella, R., Perez, JM., Chollet-Martin, S. et al. Burkholderia pseudomallei infection in chronic granulomatous disease. Eur J Pediatr 165, 175–177 (2006). https://doi.org/10.1007/s00431-005-0022-y

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  • DOI: https://doi.org/10.1007/s00431-005-0022-y

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