Abstract
Microstructural properties of white matter pathways are associated with concurrent reading abilities in children. In this longitudinal study, we asked whether properties of white matter pathways at the onset of learning to read would be associated with reading abilities at older ages. Children (N = 37) with a wide range of reading abilities completed standardized measures of language and phonological awareness and diffusion MRI at age 6 years. Mean tract-fractional anisotropy (FA) was extracted from reading-related pathways. At age 8, the same children were re-assessed using a standardized reading measure. Using linear regressions, we examined the contribution of tract-FA at age 6 to reading outcome at age 8, beyond known demographic and pre-literacy predictors of reading. Tract-FA of the left arcuate, left and right superior longitudinal fasciculus (SLF), and left inferior cerebellar peduncle (ICP) made unique contributions to reading outcome after consideration of sex and family history of reading delays. Tract-FA of the left and right SLF and left ICP made unique contributions to reading outcome after the addition of pre-literacy skills. Thus, cerebellar and bilateral cortical pathways represented a network associated with subsequent reading abilities. Early white matter properties may be associated with other neuropsychological functions that predict reading or may influence reading development, independent of reading-related abilities. Tract FA at early stages of learning to read may serve as a biomarker of later reading abilities.
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References
Agosta F, Scola E, Canu E, Marcone A, Magnani G, Sarro L, Filippi M (2012) White matter damage in frontotemporal lobar degeneration spectrum. Cereb Cortex 22(12):2705–2714. https://doi.org/10.1093/cercor/bhr288
Aikens NL, Barbarin O (2008) Socioeconomic differences in reading trajectories: the contribution of family, neighborhood, and school contexts. J Educ Psychol 100(2):235–251. https://doi.org/10.1037/0022-0663.100.2.235
Arrington CN, Kulesz PA, Juranek J, Cirino PT, Fletcher JM (2017) White matter microstructure integrity in relation to reading proficiency☆. Brain Lang 174(August):103–111. https://doi.org/10.1016/j.bandl.2017.08.002
Assaf Y, Blumenfeld-Katzir T, Yovel Y, Basser PJ (2008) Axcaliber: a method for measuring axon diameter distribution from diffusion MRI. Magn Reson Med 59(6):1347–1354. https://doi.org/10.1002/mrm.21577
Barnea-Goraly N, Menon V, Eckert M, Tamm L, Bammer R, Karchemskiy A, Reiss AL (2005) White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study. Cerebral Cortex (New York, NY: 1991) 15(12):1848–1854. https://doi.org/10.1093/cercor/bhi062
Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system—a technical review. NMR Biomed 15(7–8):435–455
Beaulieu C, Plewes C, Paulson LA, Roy D, Snook L, Concha L, Phillips L (2005) Imaging brain connectivity in children with diverse reading ability. NeuroImage 25(4):1266–1271. https://doi.org/10.1016/J.NEUROIMAGE.2004.12.053
Blair C, Razza RP (2007) Relating effortful control, executive function, and false belief understanding to emerging math and literacy ability in kindergarten. Child Dev 78(2):647–663. https://doi.org/10.1111/j.1467-8624.2007.01019.x
Brauer J, Anwander A, Perani D, Friederici AD (2013) Dorsal and ventral pathways in language development. Brain Lang. https://doi.org/10.1016/j.bandl.2013.03.001
Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BTT (2011) The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol 106(5):2322–2345. https://doi.org/10.1152/jn.00339.2011
Cain K, Oakhill J, Bryant P (2004) Children’s reading comprehension ability: concurrent prediction by working memory, verbal ability, and component skills. J Educ Psychol. https://doi.org/10.1037/0022-0663.96.1.31
Chang L-C, Jones DK, Pierpaoli C (2005) RESTORE: Robust estimation of tensors by outlier rejection. Magn Reson Med 53(5):1088–1095. https://doi.org/10.1002/mrm.20426
Christodoulou JA, Murtagh J, Cyr A, Perrachione TK, Chang P, Halverson K, Gabrieli JDE (2017) Relation of white-matter microstructure to reading ability and disability in beginning readers. Neuropsychology 31(5):508–515. https://doi.org/10.1037/neu0000243
Cummine J, Dai W, Borowsky R, Gould L, Rollans C, Boliek C (2015) Investigating the ventral-lexical, dorsal-sublexical model of basic reading processes using diffusion tensor imaging. Brain Struct Fun 220(1):445–455. https://doi.org/10.1007/s00429-013-0666-8
Desmond JE, Fiez JA (1998) Neuroimaging studies of the cerebellum: language, learning and memory. Trends in Cognit Sci 2(9):355–362. https://doi.org/10.1016/S1364-6613(98)01211-X
Deutsch GK, Dougherty RF, Bammer R, Siok WT, Gabrieli JDE, Wandell B (2005) Children’s reading performance is correlated with white matter structure measured by diffusion tensor imaging. Cortex 41(3):354–363. https://doi.org/10.1016/S0010-9452(08)70272-7
Dick AS, Bernal B, Tremblay P (2014) The language connectome. Neuroscientist 20(5):453–467. https://doi.org/10.1177/1073858413513502
Diehl B, Busch RM, Duncan JS, Piao Z, Tkach J, Lüders HO (2008) Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy. Epilepsia 49(8):1409–1418. https://doi.org/10.1111/j.1528-1167.2008.01596.x
Dodson C, Travis K, Borchers L, Marchman V, Ben-Shachar M, Feldman H (2018) White matter properties associated with prereading skills in 6-year-old children born preterm and at term. Dev Med Child Neurol. https://doi.org/10.1111/dmcn.13783
Dougherty RF, Ben-Shachar M, Deutsch GK, Hernandez A, Fox GR, Wandell BA (2007) Temporal-callosal pathway diffusivity predicts phonological skills in children. Proc Natl Acad Sci 104(20):8556–8561. https://doi.org/www.pnas.org?cgi?doi?10.1073?pnas.0608961104
Eckert MA, Leonard CM, Richards TL, Aylward EH, Thomson J, Berninger VW (2003) Anatomical correlates of dyslexia: frontal and cerebellar findings. Brain 126(2):482–494. https://doi.org/10.1093/brain/awg026
Eckert MA, Leonard CM, Wilke M, Eckert M, Richards T, Richards A, Berninger V (2005) Anatomical signatures of dyslexia in children: unique information from manual and voxel based morphometry brain measures. Cortex 41(3):304–315. https://doi.org/10.1016/S0010-9452(08)70268-5
Ehri LC (2005) Learning to read words: theory, findings, and issues. Sci Stud Read 9(2):167–188. https://doi.org/10.1207/s1532799xssr0902_4
Feldman HM, Lee ES, Yeatman JD, Yeom KW (2012) Language and reading skills in school-aged children and adolescents born preterm are associated with white matter properties on diffusion tensor imaging. Neuropsychologia 50(14):3348–3362. https://doi.org/10.1016/j.neuropsychologia.2012.10.014
Fernandez VG, Stuebing K, Juranek J, Fletcher JM (2013) Volumetric analysis of regional variability in the cerebellum of children with dyslexia. The Cerebellum 12(6):906–915. https://doi.org/10.1007/s12311-013-0504-9
Field A (2013) Discovering statistics using IBM SPSS statistics. Sage, Thousand Oaks
Friederici AD, Bahlmann J, Heim S, Schubotz RI, Anwander A (2006) The brain differentiates human and non-human grammars: functional localization and structural connectivity. Proc Natl Acad Sci USA 103(7):2458–2463. https://doi.org/10.1073/pnas.0509389103
Friston KJ, Ashburner J (2004) Generative and recognition models for neuroanatomy. NeuroImage 23(1):21–24. https://doi.org/10.1016/j.neuroimage.2004.04.021
Frye RE, Landry SH, Swank PR, Smith KE (2009) Executive dysfunction in poor readers born prematurely at high risk. Dev Neuropsychol 34(3):254–271. https://doi.org/10.1080/87565640902805727
Fulbright RK, Jenner AR, Mencl WE, Pugh KR, Shaywitz BA, Shaywitz SE, Gore JC (1999) The cerebellum’s role in reading: a functional MR imaging study. Am J Neuroradiol 20(10):1925–1930. http://www.ncbi.nlm.nih.gov/pubmed/10588120
Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, … Gorno-Tempini ML (2011) White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain 134(10):3011–3029. https://doi.org/10.1093/brain/awr099
Gilger JW, Hanebuth E, Smith SD, Pennington BF (1996) Differential risk for developmental reading disorders in the offspring of compensated versus noncompensated parents. Read Writ 8(5):407–417. https://doi.org/10.1007/bf00404002
Giorgio A, Watkins KE, Chadwick M, James S, Winmill L, Douaud G, … James AC (2010) Longitudinal changes in grey and white matter during adolescence. NeuroImage 49(1):94–103. https://doi.org/10.1016/j.neuroimage.2009.08.003
Goswami U, Bryant P (1990) Phonological skills and learning to read. J Child Psychol Psychiatry 32(7):1173–1176. https://doi.org/10.1111/j.1469-7610.1991.tb00359.x
Gough PB, Tunmer WE (1986) Decoding, reading, and reading disability. Remedial Spec Educ 7(1):6–10. https://doi.org/10.1177/074193258600700104
Griffiths JD, Marslen-Wilson WD, Stamatakis EA, Tyler LK (2013) Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax. Cereb Cortex 23(1):139–147. https://doi.org/10.1093/cercor/bhr386
Hickok G, Poeppel D (2004) Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition 92(1–2):67–99. https://doi.org/10.1016/J.COGNITION.2003.10.011
Hoeft F, McCandliss BD, Black JM, Gantman A, Zakerani N, Hulme C, Gabrieli JDE (2011) Neural systems predicting long-term outcome in dyslexia. Proc Natl Acad Sci 108(1):361–366. https://doi.org/10.1073/pnas.1008950108
Hoover WA, Gough PB (1990) The simple view of reading. Read Writ 2(2):127–160. https://doi.org/10.1007/BF00401799
Hua K, Zhang J, Wakana S, Jiang H, Li X, Reich DS, … Mori S (2008) Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. NeuroImage 39(1):336–347. https://doi.org/10.1016/J.NEUROIMAGE.2007.07.053
Hulme C (2002) Phonemes, rimes, and the mechanisms of early reading development. J Exp Child Psychol 82(1):58–64. https://doi.org/10.1006/JECP.2002.2674
Jansen A, Flöel A, Van Randenborgh J, Konrad C, Rotte M, Förster A-F, … Knecht S (2005) Crossed cerebro-cerebellar language dominance. Hum Brain Mapp 24(3):165–172. https://doi.org/10.1002/hbm.20077
Jones DK, Cercignani M (2010) Twenty-five pitfalls in the analysis of diffusion MRI data. NMR Biomed 23(7):803–820. https://doi.org/10.1002/nbm.1543
Keller TA, Just MA (2009) Altering cortical connectivity: remediation-induced changes in the white matter of poor readers. Neuron 64(5):624–631. https://doi.org/10.1016/J.NEURON.2009.10.018
Kirby JR, Parrila RK, Pfeiffer SL (2003) Naming speed and phonological awareness as predictors of reading development. J Educ Psychol. https://doi.org/10.1037/0022-0663.95.3.453
Kovachy VN, Adams JN, Tamaresis JS, Feldman HM (2015) Reading abilities in school-aged preterm children: a review and meta-analysis. Developmental Medicine Child Neurology 57(5):410–419. https://doi.org/10.1111/dmcn.12652
Kraft I, Schreiber J, Cafiero R, Metere R, Schaadt G, Brauer J, Skeide MA (2016) Predicting early signs of dyslexia at a preliterate age by combining behavioral assessment with structural MRI. NeuroImage 143:378–386. https://doi.org/10.1016/j.neuroimage.2016.09.004
Langer N, Peysakhovich B, Zuk J, Drottar M, Sliva DD, Smith S, Gaab N (2015) White matter alterations in infants at risk for developmental dyslexia. Cereb Cortex 27(2):bhv281. https://doi.org/10.1093/cercor/bhv281
Laycock SK, Wilkinson ID, Wallis LI, Darwent G, Wonders SH, Fawcett AJ, Nicolson RI (2008) Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia. Ann N Y Acad Sci 1145(1):222–236. https://doi.org/10.1196/annals.1416.002
Lebel C, Shaywitz B, Holahan J, Shaywitz S, Marchione K, Beaulieu C (2013) Diffusion tensor imaging correlates of reading ability in dysfluent and non-impaired readers. Brain Lang 125(2):215–222. https://doi.org/10.1016/J.BANDL.2012.10.009
McCandliss BD, Noble KG (2003) The development of reading impairment: a cognitive neuroscience model. Mental Retard Dev Disabil Res Rev 9(3):196–204. https://doi.org/10.1002/mrdd.10080
McDonald CR, Ahmadi ME, Hagler DJ, Tecoma ES, Iragui VJ, Gharapetian L, Halgren E (2008) Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy. Neurology 71(23):1869–1876. https://doi.org/10.1212/01.wnl.0000327824.05348.3b
Mezer A, Yeatman JD, Stikov N, Kay KN, Cho N-J, Dougherty RF, … Wandell BA (2013) Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging. Nat Med 19(12):1667–1672. https://doi.org/10.1038/nm.3390
Mukherjee P, Miller JH, Shimony JS, Conturo TE, Lee BC, Almli CR, McKinstry RC (2001) Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology 221(2):349–358. https://doi.org/10.1148/radiol.2212001702
Myers CA, Vandermosten M, Farris EA, Hancock R, Gimenez P, Black JM, Hoeft F (2014) White matter morphometric changes uniquely predict children’s reading acquisition. Psychol Sci 25(10):1870–1883. https://doi.org/10.1177/0956797614544511
Naidich TP, Duvernoy HM (2009) Duvernoy’s atlas of the human brain stem and cerebellum: high-field MRI: surface anatomy, internal structure, vascularization and 3D sectional anatomy. Springer, New York
Nation K, Snowling MJ (2004) Beyond phonological skills: broader language skills contribute to the development of reading. J Res Read 27(4):342–356. https://doi.org/10.1111/j.1467-9817.2004.00238.x
Niogi SN, McCandliss BD (2006) Left lateralized white matter microstructure accounts for individual differences in reading ability and disability. Neuropsychologia 44(11):2178–2188. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2006.01.011
O’Connor RE, Fulmer D, Harty KR, Bell KM (2005) Layers of reading intervention in kindergarten through third grade. J Learn Disabil 38(5):440–455
Odegard TN, Farris EA, Ring J, McColl R, Black J (2009) Brain connectivity in non-reading impaired children and children diagnosed with developmental dyslexia. Neuropsychologia 47(8–9):1972–1977. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2009.03.009
Olofsson Å, Niedersøe J (1999) Early language development and kindergarten phonological awareness as predictors of reading problems. J Learn Disabil 32(5):464–472. https://doi.org/10.1177/002221949903200512
Perfetti CA (1992) The representation problem in reading acquisition. In: Reading acquisition. Lawrence Erlbaum Associates, Inc, Hillsdale
Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME (1988) Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 331(6157):585–589. https://doi.org/10.1038/331585a0
Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME (1989) Positron emission tomographic studies of the processing of singe words. J Cogn Neurosci 1(2):153–170. https://doi.org/10.1162/jocn.1989.1.2.153
Peterson RL, Pennington BF (2012) Developmental dyslexia. Lancet 379:1997–2007. https://doi.org/10.1016/S0140-6736(12)60198-6
Price CJ (2012) A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. NeuroImage 62(2):816–847. https://doi.org/10.1016/J.NEUROIMAGE.2012.04.062
Rohde GK, Barnett AS, Basser PJ, Marenco S, Pierpaoli C (2004) Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI. Magn Reson Med 51(1):103–114. https://doi.org/10.1002/mrm.10677
Romeo RR, Christodoulou JA, Halverson KK, Murtagh J, Cyr AB, Schimmel C, Gabrieli JDE (2017) Socioeconomic status and reading disability: neuroanatomy and plasticity in response to intervention. Cereb Cortex, 1–16. https://doi.org/10.1093/cercor/bhx131
Rutter M, Caspi A, Fergusson D, Horwood LJ, Goodman R, Maughan B, Carroll J (2004) Sex differences in developmental reading disability. JAMA 291(16):2007. https://doi.org/10.1001/jama.291.16.2007
Saygin ZM, Norton ES, Osher DE, Beach SD, Cyr AB, Ozernov-Palchik O, Gabrieli JDE (2013) Tracking the roots of reading ability: white matter volume and integrity correlate with phonological awareness in prereading and early-reading kindergarten children. J Neurosci 33(33):13251–13258. https://doi.org/10.1523/JNEUROSCI.4383-12.2013
Schatschneider C, Fletcher JM, Francis DJ, Carlson CD, Foorman BR (2004) Kindergarten prediction of reading skills: a longitudinal comparative analysis. J Educ Psychol 96(2):265–282. https://doi.org/10.1037/0022-0663.96.2.265
Scott SK, Wise RJS (2004) The functional neuroanatomy of prelexical processing in speech perception. Cognition 92(1–2):13–45. https://doi.org/10.1016/J.COGNITION.2002.12.002
Senaha MLH, Martin MGM, Amaro E Jr, Campi C, Caramelli P (2005) Patterns of cerebral activation during lexical and phonological reading in Portuguese. Braz J Med Biol Res 38(12):1847–1856. https://doi.org/10.1590/S0100-879X2005001200013
Shaywitz SE, Shaywitz BA, Fletcher JM, Escobar MD (1990) Prevalence of reading disability in boys and girls. Results of the Connecticut longitudinal study. J Am Med Assoc 264(1):998–1002. https://doi.org/10.1001/jama.264.8.998
Shaywitz SE, Escobar MD, Shaywitz BA, Fletcher JM, Makuch R (1992) Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability. N Engl J Med 326(3):145–150. https://doi.org/10.1056/NEJM199201163260301
Snook L, Paulson LA, Roy D, Phillips L, Beaulieu C (2005) Diffusion tensor imaging of neurodevelopment in children and young adults. NeuroImage 26(4):1164–1173. https://doi.org/10.1016/j.neuroimage.2005.03.016
Snow CE (1991) The theoretical basis for relationships between language and literacy in development. J Res Child Educ 6(1):5–10. https://doi.org/10.1080/02568549109594817
Snowling MJ, Gallagher A, Frith U (2003) Family risk of dyslexia is continuous: individual differences in the precursors of reading skill. Child Dev 74(2):358–373. https://doi.org/10.1111/1467-8624.7402003
Stein JF, Richardson AJ, Fowler MS (2000) Monocular occlusion can improve binocular control and reading in dyslexics. Brain 123(1):164–170. https://doi.org/10.1093/brain/123.1.164
Steinbrink C, Vogt K, Kastrup A, Müller H-P, Juengling FD, Kassubek J, Riecker A (2008) The contribution of white and gray matter differences to developmental dyslexia: Insights from DTI and VBM at 3.0 T. Neuropsychologia 46(13):3170–3178. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2008.07.015
Stoodley CJ (2012) The cerebellum and cognition: evidence from functional imaging studies. The Cerebellum 11(2):352–365. https://doi.org/10.1007/s12311-011-0260-7
Stoodley CJ, Schmahmann JD (2009) Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. NeuroImage 44(2):489–501. https://doi.org/10.1016/J.NEUROIMAGE.2008.08.039
Thiebaut de Schotten M, Cohen L, Amemiya E, Braga LW, Dehaene S (2014) Learning to read improves the structure of the arcuate fasciculus. Cereb Cortex 24(4):989–995. https://doi.org/10.1093/cercor/bhs383
Travis KE, Leitner Y, Feldman HM, Ben-Shachar M (2015) Cerebellar white matter pathways are associated with reading skills in children and adolescents. Hum Brain Mapp 36(4):1536–1553. https://doi.org/10.1002/hbm.22721
Travis KE, Ben-Shachar M, Myall NJ, Feldman HM (2016a) Variations in the neurobiology of reading in children and adolescents born full term and preterm. NeuroImage: Clin 11:555–565. https://doi.org/10.1016/J.NICL.2016.04.003
Travis KE, Adams JN, Kovachy VN, Ben-Shachar M, Feldman HM (2016b) White matter properties differ in 6-year old Readers and Pre-readers. Brain Struct Fun. https://doi.org/10.1007/s00429-016-1302-1
Urger SE, De Bellis MD, Hooper SR, Woolley DP, Chen SD, Provenzale J (2015) The superior longitudinal fasciculus in typically developing children and adolescents. J Child Neurol 30(1):9–20. https://doi.org/10.1177/0883073813520503
Vanderauwera J, Wouters J, Vandermosten M, Ghesquière P (2017) Early dynamics of white matter deficits in children developing dyslexia. Dev Cogn Neurosci 27(August):69–77. https://doi.org/10.1016/j.dcn.2017.08.003
Vandermosten M, Boets B, Wouters J, Ghesquière P (2012) A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia. Neurosci Biobehav Rev 36(6):1532–1552. https://doi.org/10.1016/J.NEUBIOREV.2012.04.002
Velay J-L, Daffaure V, Giraud K, Habib M (2002) Interhemispheric sensorimotor integration in pointing movements: a study on dyslexic adults. Neuropsychologia 40(7):827–834. https://doi.org/10.1016/S0028-3932(01)00177-4
Vos SB, Jones DK, Viergever MA, Leemans A (2011) Partial volume effect as a hidden covariate in DTI analyses. NeuroImage 55(4):1566–1576. https://doi.org/10.1016/j.neuroimage.2011.01.048
Wagner RK, Torgesen JK (1987) The nature of phonological processing and its causal role in the acquisition of reading skills. Psychol Bull 101(2):192–212. https://doi.org/10.1037/0033-2909.101.2.192
Wagner RK, Torgesen JK, Rashotte CA, Hecht SA, Barker TA, Burgess SR, Garon T (1997) Changing relations between phonological processing abilities and word-level reading as children develop from beginning to skilled readers: a 5-year longitudinal study. Dev Psychol 33(3):468–479. https://doi.org/10.1037/0012-1649.33.3.468
Wagner RK, Torgesen JK, Rashotte CA (1999) Comprehensive test of phonological processing: CTOPP. Austin, TX: Pro-Ed. Retrieved from https://search.library.wisc.edu/catalog/9910495627902121
Wang Y, Mauer MV, Raney T, Peysakhovich B, Becker BLC, Sliva DD, Gaab N (2017) Development of tract-specific white matter pathways during early reading development in at-risk children and typical controls. Cerebral Cortex (New York, N.Y.: 1991) 27(4):2469–2485. https://doi.org/10.1093/cercor/bhw095
Wheeler-Kingshott CAM, Cercignani M (2009) About “axial” and “radial” diffusivities. Magn Reson Med 61(5):1255–1260. https://doi.org/10.1002/mrm.21965
Yeatman JD, Dougherty RF, Rykhlevskaia E, Sherbondy AJ, Deutsch GK, Wandell BA, Ben-Shachar M (2011) Anatomical properties of the arcuate fasciculus predict phonological and reading skills in children. J Cogn Neurosci 23(11):3304–3317. https://doi.org/10.1162/jocn_a_00061
Yeatman JD, Dougherty RF, Ben-Shachar M, Wandell BA (2012a) Development of white matter and reading skills. Proc Natl Acad Sci 109(44):E3045–E3053. https://doi.org/10.1073/pnas.1206792109
Yeatman JD, Dougherty RF, Myall NJ, Wandell BA, Feldman HM (2012b) Tract profiles of white matter properties: automating fiber-tract quantification. PloS One 7(11):e49790. https://doi.org/10.1371/journal.pone.0049790
Acknowledgements
We would like the thank the children and families who participated in this longitudinal project. We would also like to thank Ms. Vanessa N. Kovachy for initial recruitment and data collection.
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This work was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (RO1 HD069162) and the Stanford Transdisciplinary Initiatives Program, Child Health Research Institute.
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Borchers, L.R., Bruckert, L., Dodson, C.K. et al. Microstructural properties of white matter pathways in relation to subsequent reading abilities in children: a longitudinal analysis. Brain Struct Funct 224, 891–905 (2019). https://doi.org/10.1007/s00429-018-1813-z
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DOI: https://doi.org/10.1007/s00429-018-1813-z