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Seasonal reorganization of hypothalamic neurogenic niche in adult sheep

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Abstract

Neurogenesis is the process by which new neurons are generated. This process, well established during development, persists in adulthood owing to the presence of neural stem cells (NSCs) localized in specific brain areas called neurogenic niches. Adult neurogenesis has recently been shown to occur in the hypothalamus, a structure involved in the neuroendocrine regulation of reproduction and metabolism, among others. In the adult sheep—a long-lived mammalian model—we have previously reported the existence of such a neurogenic niche located in the hypothalamic arcuate nucleus and the median eminence. In addition, in this seasonal species, the proliferation as well as neuroblasts production varies depending on the time of the year. In the present study, we provide a better characterization of the hypothalamic neurogenic niche by identifying the main components (NSCs, migrating cells, glial cells and blood vessels) using immunohistochemistry for validated markers. Then, we demonstrate the strong sensitivity of these various neurogenic niche components to the season, particularly in the arcuate nucleus. Further, using an electron microscopic approach, we reveal the cellular and cytoarchitectural reorganization of the arcuate nucleus niche following exposure to contrasting seasons. This study provides evidence that the arcuate nucleus and the median eminence contain two independent niches that react differently to the season. In addition, our results support the view that the cytoarchitectural organization of the sheep arcuate nucleus share comparable features with the structure of the subventricular zone in humans and non-human primates.

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Acknowledgements

The authors wish to thank the experimental unit PAO No. 1297 (EU0028; INRA Val de Loire) for animal care. This work was funded by the French National Research Agency (Agence Nationale pour la Recherche: ANR-09-JCJC-0049-01). L. Butruille is a Ph.D. student supported by the Région Centre. We also wish to thank the PIC platform and more specifically M. Letheule. The authors thank Dr. S. Rasika for her critical comments on the manuscript.

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Authors and Affiliations

  1. INRA, UMR 85 Physiologie de la Reproduction et des Comportements, Equipe ER3 Microenvironment and Dynamics of Neuroendocrine Networks (MiDyNNet), 37380, Nouzilly, France

    Lucile Butruille, Martine Batailler & Martine Migaud

  2. CNRS, UMR7247, 37380, Nouzilly, France

    Lucile Butruille, Martine Batailler & Martine Migaud

  3. Université de Tours, 37041, Tours, France

    Lucile Butruille, Martine Batailler & Martine Migaud

  4. Haras Nationaux, 37380, Nouzilly, France

    Lucile Butruille, Martine Batailler & Martine Migaud

  5. Inserm, Centre de Recherche Jean-Pierre Aubert, UMR837, Development and Plasticity of the Postnatal Brain, UDSL, Université Lille Nord de France, 59045, Lille, France

    Danièle Mazur & Vincent Prévot

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  1. Lucile Butruille
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  2. Martine Batailler
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  3. Danièle Mazur
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  4. Vincent Prévot
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  5. Martine Migaud
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Correspondence to Martine Migaud.

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Butruille, L., Batailler, M., Mazur, D. et al. Seasonal reorganization of hypothalamic neurogenic niche in adult sheep. Brain Struct Funct 223, 91–109 (2018). https://doi.org/10.1007/s00429-017-1478-z

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  • DOI: https://doi.org/10.1007/s00429-017-1478-z

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