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Neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: comparison of young adult and geriatric marmoset monkeys

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Abstract

Neuronal loss in the lateral geniculate nucleus (LGN) is a consequence of lesions of the primary visual cortex (V1). Despite the importance of this phenomenon in understanding the residual capacities of the primate visual system following V1 damage, few quantitative studies are available, and the effect of age at the time of lesion remains unknown. We compared the volume, neuronal number, and neuronal density in the LGN, 6–21 months after unilateral V1 lesions in marmoset monkeys. Stereological sampling techniques and neuronal nuclei (NeuN) staining were used to assess the effects of similar-sized lesions in adult (2–4 years) and geriatric (10–14 years) animals. We found that lesions involving the opercular and caudal calcarine parts of V1 caused robust loss of neurons in topographically corresponding regions of the ipsilateral LGN (lesion projection zones), concomitant with a substantial reduction in the volume of this nucleus. Neuronal density was markedly reduced in the lesion projection zones, relative to the corresponding regions of the contralateral LGN, or the LGN in non-lesioned animals. Moreover, the percentage decrease in neuronal density within the lesion projection zones was significantly greater in the geriatric group, compared with the adult groups. The volume and neuronal density in the contralateral LGN of lesioned adult and geriatric marmosets were similar to those in non-lesioned animals. These results show that the primate LGN becomes more vulnerable to degeneration with advancing age. However, even in geriatric primates there is a population of LGN neurons which survives degeneration, and which could play a role in blindsight.

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Acknowledgements

The authors thank Rowan Tweedale for many suggestions that improved this manuscript, and acknowledge the contributions of Jonathan Chan and of the Monash Histology Platform, Department of Anatomy and Developmental Biology, for the slide scanning. Supported by research grants from the National Health and Medical Research Council (1066232, 1122220) and Australian Research Council (CE140100007, DE130100493, DE140101505).

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Authors and Affiliations

  1. Neuroscience Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia

    Nafiseh Atapour, Katrina H. Worthy, Leo L. Lui, Hsin-Hao Yu & Marcello G. P. Rosa

  2. Australian Research Council, Centre of Excellence for Integrative Brain Function, Monash University Node, Melbourne, VIC, Australia

    Nafiseh Atapour, Leo L. Lui, Hsin-Hao Yu & Marcello G. P. Rosa

  3. Department of Physiology, Monash University, Clayton, Melbourne, VIC, 3800, Australia

    Nafiseh Atapour, Katrina H. Worthy, Leo L. Lui, Hsin-Hao Yu & Marcello G. P. Rosa

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  1. Nafiseh Atapour
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Correspondence to Nafiseh Atapour.

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Atapour, N., Worthy, K.H., Lui, L.L. et al. Neuronal degeneration in the dorsal lateral geniculate nucleus following lesions of primary visual cortex: comparison of young adult and geriatric marmoset monkeys. Brain Struct Funct 222, 3283–3293 (2017). https://doi.org/10.1007/s00429-017-1404-4

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