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Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids

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Abstract

Although ovarian monodermal teratomas, including struma ovarii and carcinoids, are closely associated with mature teratomas, their genetic basis is poorly understood. A series of mature and monodermal ovarian teratomas were analyzed by short tandem repeat genotyping to evaluate their genetic zygosity and its associations. Informative DNA genotyping data were obtained for ten mature teratomas, six struma ovarii, and three carcinoids (one insular, one trabecular, and one mucinous). A homozygous genotype was present in five of the ten (50%) mature teratomas, three of the six (50%) struma ovarii, and one of the three (33%) ovarian carcinoids. There was no significant difference in genetic zygosity between mature and monodermal teratomas. Patients’ age was not correlated with the genetic zygosity: the youngest age in the homozygous tumor group of patients was 4 years. It is suggested that an oocyte after meiosis I, which has escaped from meiotic arrest, is a significant cause of these tumors. Although one mature teratoma was a rare case with lactating adenoma-like breast tissue, its genetic zygosity was concordant with that of the surrounding teratomatous tissue. In one ovarian carcinoid, the carcinoid and accompanying teratomatous components showed matching zygosity at all but one locus: the carcinoid was heterozygous but teratoma was homozygous at one pericentromeric locus. This suggests that not all carcinoids are secondary neoplasms arising from a fully developed mature teratoma: some are neoplasms deviating from a developing mature teratoma.

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References

  1. Prat J (2014) Ovarian germ cell tumors. In: Mutter GL, Prat J (eds) Pathology of the female reproductive tract, 3rd edn. Churchill Livingstone, London, pp 670–693

    Google Scholar 

  2. Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratomas. New Engl J Med 292:63–66

    Article  PubMed  CAS  Google Scholar 

  3. Vortmeyer AO, Devouassoux-Shisheboran M, Li G, Mohr V, Tavassoli F, Zhuang Z (1999) Microdissection-based analysis of mature ovarian teratoma. Am J Pathol 154:987–991

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Surti U, Hoffner L, Chakravarti A, Ferrell RE (1990) Genetics and biology of human ovarian teratomas. I. Cytogenetic analysis and mechanism of origin. Am J Hum Genet 47:635–643

    PubMed  PubMed Central  CAS  Google Scholar 

  5. Deka R, Chakravarti A, Surti U, Hauselman E, Reefer J, Majumder PP, Ferrell RE (1990) Genetics and biology of human ovarian teratomas. II. Molecular analysis of origin of nondisjunction and gene-centromere mapping of chromosome I markers. Am J Hum Genet 47:644–655

    PubMed  PubMed Central  CAS  Google Scholar 

  6. Dahl N, Gustavson K-H, Rune C, Gustavsson I, Pettersson U (1990) Benign ovarian teratomas. An analysis of their cellular origin. Cancer Genet Cytogenet 46:115–123

    Article  PubMed  CAS  Google Scholar 

  7. Snir OL, DeJoseph M, Wong S, Buza N, Hui P (2017) Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis. Mod Pathol 30:1467–1475

    Article  PubMed  CAS  Google Scholar 

  8. Prat J, Cao D, Carinelli SG et al (2014) Monodermal teratomas and somatic-type tumours arising from a dermoid cyst. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH (eds) WHO classification of tumours of female reproductive organs. International Agency for Research on Cancer, Lyon, pp 63–66

    Google Scholar 

  9. Ohtaki H, Yamamoto T, Yoshimoto T, Uchihi R, Ooshima C, Katsumata Y, Tokunaga K (2002) A powerful, novel, multiplex typing system for six short tandem repeat loci and the allele frequency distributions in two Japanese regional populations. Electrophoresis 23:3332–3340

    Article  PubMed  CAS  Google Scholar 

  10. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P (2014) The cell cycle. In: Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P (eds) Molecular biology of the cell, 6th edn. Garland Science, New York, pp 963–1020

  11. Woodruf JD, Rauh JT, Markley RL (1966) Ovarian struma. Obstet Gynecol 27:194–201

    Google Scholar 

  12. Sitasuwan T, Hanamornroongruang S, Peerapatdit T, Thongtang N (2015) Coexistence of Graves’ disease and unilateral functioning struma ovarii: a case report. BMC Endocr Disord 15:68. https://doi.org/10.1186/s12902-015-0060-z

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Oi RH, Dobbs M (1978) Lactating breast tissue in benign cystic teratoma. Am J Obstet Gynecol 130:729–731

    Article  PubMed  CAS  Google Scholar 

  14. Ulirsh RC, Goldman RL (1982) An unusual teratoma of the ovary: neurogenic cyst with lactating breast tissue. Obstet Gynecol 60:400–402

    Google Scholar 

  15. Devouassoux-Schisheboran M, Vortmeyer AO, Silver SA, Zhuang Z, Tavassoli FA (2000) Teratomatous genotype detected in malignancies of a non-germ cell phenotype. Lab Invest 80:81–86

  16. Kleist B, Poetsch M (2015) Neuroendocrine differentiation: the mysterious fellow of colorectal cancer. World J Gastroenterol 21:11740–11747

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, 036-8562, Japan

    Noriko Kato, Koutaro Murakami, Yuri Iwasaki, Akihisa Kamataki & Akira Kurose

  2. Department of Pathology, Oosaki Citizen Hospital, Oosaki, Japan

    Kazuhiro Sakamoto

Authors
  1. Noriko Kato
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  2. Kazuhiro Sakamoto
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  3. Koutaro Murakami
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  4. Yuri Iwasaki
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  5. Akihisa Kamataki
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  6. Akira Kurose
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Correspondence to Noriko Kato.

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The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

No research involving human participants and/or animals. All materials were formalin-fixed, paraffin-embedded archival materials from the pathology archive.

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Not applicable. All materials were formalin-fixed, paraffin-embedded archival materials from the pathology archive. There is no identifiable patient information.

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Kato, N., Sakamoto, K., Murakami, K. et al. Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. Virchows Arch 473, 177–182 (2018). https://doi.org/10.1007/s00428-018-2319-z

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  • DOI: https://doi.org/10.1007/s00428-018-2319-z

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