Abstract
Jakob Erdheim (1874–1937) was a Viennese pathologist who identified and defined a category of pituitary tumors known as craniopharyngiomas. He named these lesions “hypophyseal duct tumors” (Hypophysenganggeschwülste), a term denoting their presumed origin from cell remnants of the hypophyseal duct, the embryological structure through which Rathke’s pouch migrates to form part of the pituitary gland. He described the two histological varieties of these lesions as the adamantinomatous and the squamous-papillary types. He also classified the different topographies of craniopharyngiomas along the hypothalamus-pituitary axis. Finally, he provided the first substantial evidence for the functional role of the hypothalamus in the regulation of metabolism and sexual functions. Erdheim’s monograph on hypophyseal duct tumors elicited interest in the clinical effects and diagnosis of pituitary tumors. It certainly contributed to the development of pituitary surgery and neuroendocrinology. Erdheim’s work was greatly influenced by the philosophy and methods of research introduced to the Medical School of Vienna by the prominent pathologist Carl Rokitansky. Routine practice of autopsies in all patients dying at the Vienna Municipal Hospital (Allgemeines Krankenhaus), as well as the preservation of rare pathological specimens in a huge collection stored at the Pathological-Anatomical Museum, represented decisive policies for Erdheim’s definition of a new category of epithelial hypophyseal growths. Because of the generalized use of the term craniopharyngioma, which replaced Erdheim’s original denomination, his seminal work on hypophyseal duct tumors is only referenced in passing in most articles and monographs on this tumor. This article is intended to pay tribute to Erdheim’s fundamental breakthroughs, his discovery of craniopharyngiomas and their functional damage to the hypothalamus. On these fundamental achievements, Jakob Erdheim should be recognized as the true father of craniopharyngiomas.
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Abbreviations
- CP:
-
Craniopharyngioma
References
Erdheim J (1904) Über Hypophysenganggeschwulste und Hirmcholesteatome. Sitzungsb Kais Akad Wissen Math Naturw Klin 113:537–726
Cushing H (1932) Intracranial tumors. In: Thomas CC (ed) Notes upon a series of two thousand verified cases with surgical mortality percentages pertaining thereto. Springfield, IL, pp. 93–98
Marie P (1889) Acromegaly. Brain 12:59–81
Babinski J (1900) Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux. Rev Neurol 8:531–533
Fröhlich A (1901) Ein all von Tumor der Hypophysis cerebri ohne Akromegalie. Wien Klin Rundschau 15(883–886):906–908
Lesky E (1976) The Vienna Medical School of the 19th century. The John Hopkins University Press, Baltimore
Rokitansky C (1855) A manual of pathological anatomy. Translated from the last German Vols III-IV edition by Swaine WE, Sieveking E, Moore CH, Day GE. Blanchard & Lea, Philadelphia
Haslhofer L (1965) E. Gedenkblatt. Jakob Erdheim. 22.5.1874 bis 21.4.1937. (1965) Verh Dtsch Ges Path 49:370–375
Rabson SM (1959) Masters of modern pathology: Jakob Erdheim. Arch Pathol 68:357–366
Romm S (1987) Jakob Erdheim. Eminent pathologist of Vienna. Am J Dermatopathol 9:447–450
Albright F (1944) Some of the “do’s and do-not’s” in clinical investigation. J Clin Invest 23:921–926
Erdheim J (1903) Zur normalen and pathologischen Histology der Glandula thyroidea, Parathyreoidea und Hypophysis. Beitr Path Anat 33:158–236
Boyce R, Beadles CF (1893) A further contribution to the study of the pathology of the hypophysis cerebri. J Pathol Bacteriol 1:359–383
Pascual JM, Prieto R, Carrasco R, Castro-Dufourny I, Barrios L (2014) Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures. Neurosurg Focus 36(4): E13
Pascual JM, Prieto R, Mazzarello P (2015) Sir Victor Horsley: the pioneer surgeon of craniopharyngiomas. J Neurosurg 20:1–13
Benda C (1900) Beiträge zur normalen und pathologischen Histologie der menschlichen Hypophysis cerebri. Berl Klin Wochnschr 37:1205–1210
Frankl-Hochwart L v (1909) Die Diagnostik der Hypophysistumoren ohne Akromegalie. Wien Med Wochenschr 59(2127):2258–2326
Creutzfeldt HG (1909) Ein Beitrag zur normalen und pathologischen Anatomie der Hypophysis cerebri des Menschen. Jahr Hamb Staatskrankenanst 13:273–294
Cushing H (1912) The pituitary body and its disorders. JB Lippincott, Philadelphia, pp. 289–291
Pascual JM, Prieto R, Navas M, Carrasco R (2010) Conquest of third ventricle craniopharyngiomas. J Neurosurg 112:1156–1161
McLean D (1930) Die Craniopharyngealtaschen Tumoren (Embryologie, Histologie, Diagnose und Therapie). Z Gesell Neurol Psychiat 126:639–682
Duffy WC (1920) Hypophyseal duct tumors. Ann Surg 72(537–555):725–757
Cruveilhier J (1829) Anatomie Pathologique du Corps Humain Vol. I, Book 2, Plate 6. Bailliere, Paris
Pascual JM, González-Llanos F, Barrios L, Roda JM (2004) Intraventricular craniopharyngiomas: topographical classification and surgical selection based on an extensive overview. Acta Neurochir 146:785–802
Pascual JM, Prieto R, Carrasco R (2011) Infundibulo-tuberal or not strictly intraventricular craniopharyngioma: evidence for a major topographical category. Acta Neurochir 153:2403–2425
Seemayer TA, Blundell JS, Wigglesworth FW (1972) Pituitary craniopharyngioma with tooth formation. Cancer 29:423–430
Harrison MJ, Morgello S, Post KD (1994) Epithelial cystic lesions of the sellar and parasellar region: a continuum of ectodermal derivatives? J Neurosurg 80:1018–1025
Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws ER (2010) Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 28: E4
Prieto R, Pascual JM (2013) Craniopharyngiomas with a mixed histological pattern: the missing link to the intringuing pathogenesis of adamantinomatous and squamous-papillary varieties? Neuropathology 33:682–686
Rathke H (1838) Ueber die Entstehung der glandula pituitaria. Archiv Anat Physiol Wissensch Med 5:482–485
Ciric IS, Cozzens JW (1980) Craniopharyngiomas: transsphenoidal method of approach—for the virtuoso only? Clin Neurosurg 27:169–187
Luse SA, Kernohan JW (1955) Squamous-cell nests of the pituitary gland. Cancer 8:623–628
Hunter IJ (1955) Squamous metaplasia of cells of the anterior pituitary gland. J Path Bact 69:141–145
Asa SL, Kovacs K, Bilbao JM (1983) The pars tuberalis of the human pituitary. A histologic, immunohistochemical, ultrastructural and immunoelectron microscopic analysis. Virchows Arch 399:49–59
Szeifert GT, Pasztor E (1993) Could craniopharyngiomas produce pituitary hormones? Neurol Res 15:68–69
Goldberg GM, Eshbaugh DE (1960) Squamous cell nests of the pituitary gland as related to the origin of craniopharyngiomas. Arch Pathol 70:293–299
Yamada H, Haratake J, Narasaki T, Oda T (1995) Embryonal craniopharyngioma. Case report of the morphogenesis of a craniopharyngioma. Cancer 75:2971–2977
Hussain I, Eloy JA, Carmel PW, Liu JK (2013) Molecular oncogenesis of craniopharyngiomas: current and future strategies for the development of targeted therapies. J Neurosurg 119:106–112
Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Tissier PL, et al (2012) Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol 124:259–271
Erdheim J (1926) Pathologie der Hypophysengeschwülste. Ergbn Allg Path u. Path Anat 21:482–561
Prieto R, Pascual JM, Barrios L (2015) Optic chiasm distortions caused by craniopharyngiomas. Clinical-MRI correlation and influence on visual outcome. World Neurosurg 83:500–529
Aschner B (1912) Über die Function der Hypophyse. Pflugers Arch 146:1–146
Bailey P, Bremer F (1921) Experimental diabetes insipidus. Arch Int Med 28:773–803
Pascual JM, Carrasco R, Prieto R, Gonzalez-Llanos F, Alvarez F, Roda JM (2008) Craniopharyngiomas classification. J Neurosurg 109:1180–1183
Castro-Dufourny I, Carrasco R, Prieto R, Barrios L, Pascual JM (2014) The infundibulo-tuberal syndrome caused by craniopharyngiomas: clinicopathological evidence from an historical French cohort (1705–1973). Pituitary 20
Young JK, Polston EK (2013) Specialized features of the arcuate nucleus of the hypothalamus. In: Dudás B (ed) The human hypothalamus: anatomy, functions and disorders. Nova Science Publishers, New York, pp. 31–66
Acknowledgments
Maria Rosdolsky, Jakob Erdheim’s great-niece and co-author of this study, feels very honored and thankful to the opportunity Dr. Pascual gave her to participate in this study. She collaborated with Mr. Eduard Winter, the director of the pathological-anatomical museum in Vienna who found specimens that Erdheim had probably used for his studies of craniopharyngioma, took pictures of the specimens, and also made copies of Erdheim’s autopsy reports. This study was supported by the Sixto Obrador Award from the Spanish Society of Neurosurgery (SENEC) granted to the best national research study of neurosurgery in 2013. The authors wish to especially thank Crystal Smith, Reference Librarian of the Department of History of Medicine at the National Library of Medicine, National Institutes of Health, Bethesda, Maryland, for her kind assistance during the process of searching and retrieving articles and monographs used in this study. The authors are also indebted to Lucretia MacLure and all the staff at the Francis Countway Medical Library at Harvard Medical School, Boston, Massachusetts, for their invaluable help in obtaining some of the original research material used for this study. Finally, the authors wish to express their gratitude to the staff in the Narrenturm and the Jakob Erdheim Institute for their kind assistance and the original pictorial material provided for this study.
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“Die Augen sind gut, aber sie schauen nicht an”
-The eyes are good, but they do not observe
Jakob Erdheim
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Pascual, J.M., Rosdolsky, M., Prieto, R. et al. Jakob Erdheim (1874–1937): father of hypophyseal-duct tumors (craniopharyngiomas). Virchows Arch 467, 459–469 (2015). https://doi.org/10.1007/s00428-015-1798-4
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DOI: https://doi.org/10.1007/s00428-015-1798-4