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Dendritic cell sarcomas/tumours of the breast: report of two cases

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Abstract

Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Suleyman Demirel University, Isparta, Turkey

    Nilgun Kapucuoglu

  2. Department of Pathology, Ankara University, Ankara, Turkey

    Sıbel Percinel

  3. Department of Pathology, Università dell’Aquila, SL No 4, L’Aquila, Italy

    Terenzio Ventura

  4. Department of Breast Cancer Pathology and Laboratory Medicine, Cancer Hospital, Tianjin Medical University, Tianjin, China

    RongGang Lang

  5. Department of Pathology, University of Nottingham, Nottingham, UK

    Wael Al-Daraji

  6. Istituto di Anatomia ed Istologia Patologica, Università di Bologna, Ospedale Bellaria, Via Altura No 3, 40139, Bologna, Italy

    Vincenzo Eusebi

Authors
  1. Nilgun Kapucuoglu
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  2. Sıbel Percinel
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  3. Terenzio Ventura
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  4. RongGang Lang
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  5. Wael Al-Daraji
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  6. Vincenzo Eusebi
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Correspondence to Vincenzo Eusebi.

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Kapucuoglu, N., Percinel, S., Ventura, T. et al. Dendritic cell sarcomas/tumours of the breast: report of two cases. Virchows Arch 454, 333–339 (2009). https://doi.org/10.1007/s00428-009-0729-7

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  • DOI: https://doi.org/10.1007/s00428-009-0729-7

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