Skip to main content
SpringerLink
Log in

Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified incidentally; two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean = 3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in five of seven cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial-antigen (MIA), epithelial membrane antigen (EMA), and parvalbumin; five of seven tumors were focally positive for CD117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p and mutation of von Hippel–Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Our conclusions are as follows: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) renal oncocytomas with intravascular extension to the branches of the renal vein have the same morphological, immunohistochemical, and cytogenetic findings as have their counterparts without evidence of intravascular invasion; (3) the absence of metastases suggests an overall benign behavior of this tumor, but this has to be substantiated by further studies with a long-term follow-up; and (4) in a renal tumor with granular cytoplasm showing renal vein extension, it is necessary to carefully exclude renal cell carcinomas such as chromophobe RCC, oncocytic variant of papillary RCC, and granular variant of clear cell RCC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Amin MB, Crotty TB, Tickoo SK, Farrow GM (1997) Renal oncocytoma: a reappraisal of morphologic features with clinocopathologic findings in 80 cases. Am J Surg Pathol 21:1–12

    Article  PubMed  CAS  Google Scholar 

  2. Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, de Peralta-Venturina M, Deshpande A, Menon M (2002) Prognostic impact of histologic subtyping of adult renal epithelial neoplasms. Am J Surg Pathol 26:281–291

    Article  PubMed  Google Scholar 

  3. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L (2005) Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol 18:161–169

    Article  PubMed  CAS  Google Scholar 

  4. Byrne DJ, Hamilton Steward PA, Lowe JW (1988) Malignant angiomyolipoma of the kidney associated with hypercalcemia. Br J Urol 62:89–90

    PubMed  CAS  Google Scholar 

  5. Chen SS, Lin AT, Chen KK, Chang LS, Chang KK, Chiang H (1996) Renal angiomyolipoma with extension into renal vein. Br J Urol 77:927–928

    PubMed  CAS  Google Scholar 

  6. Davis CJ, Sesterhenn IA, Mostofi FK, Ho CK (1991) Renal oncocytoma: clinicopathological study of 166 patients. J Urogenital Pathol 1:41–52

    Google Scholar 

  7. Eble JN (1998) Angiomyolipoma of kidney. Sem Diagn Pathol 15:21–40

    CAS  Google Scholar 

  8. Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) (2004) In: Tumours of the urinary system and male genital organs. Pathology and genetics. IARC Press, Lyon

    Google Scholar 

  9. Hes O, Brunelli M, Michal M, Cossu Rocca P, Hora M, Chilosi M, Mina M, Boudová L, Menestrina F, Martignoni G (2006) Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. Ann Diagn Pathol 10:133–139

    Article  PubMed  Google Scholar 

  10. Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, Eble JN, Fleming S, Ljungberg B, Medeiros LJ, Moch H, Reuter VE, Ritz E, Roos G, Schmidt D, Srigley JR, Storkel S, van Den Berg E, Zbar B (1997) The Heidelberg classification of renal cell tumours. J Pathol 183:131–133

    Article  PubMed  CAS  Google Scholar 

  11. Lefevre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y (2005) Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J Surg Pathol 29:1576–1581

    Article  PubMed  Google Scholar 

  12. Lemley KV, Kriz W (1994) Structure and function of the renal vasculature. In: Tisher CC, Brenner BM (eds) Renal pathology with clinical and functional correlations. 2nd edn. Lippincott, Philadelphia, pp 981–1026

    Google Scholar 

  13. Lieber MM, Tomera KM, Farrow GM (1993) Renal oncocytoma: clinical and biological correlates. J Urol 150:1380–1383

    Google Scholar 

  14. Ligato S, Ro JY, Tamboli P, Amin MB, Ayala AG (1999) Benign tumours and tumour-like lesions of the adult kidney part I: Benign renal epithelial neoplasms. Adv Anat Pathol 6:1–11

    Article  PubMed  CAS  Google Scholar 

  15. Martignoni G, Pea M, Brunelli M, Eble JN (2002) Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases. Arch Pathol Lab Med 126:610–612

    PubMed  Google Scholar 

  16. Medeiros LJ, Palmedo G, Krigman HR, Kovacs G, Beckwith JB (1999) Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity. Am J Surg Pathol 23:772–780

    Article  PubMed  CAS  Google Scholar 

  17. Mostofi FK, Davies CJ (1998) Histological typing of kidney tumors, 2nd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  18. Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB, Reuter VE (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 21:871–883

    Article  PubMed  CAS  Google Scholar 

  19. Piper J, Stegenga S, Pestova E, Marble H, Lucas M, Wilber K, King W (2002) An objective method for detecting copy-number changes in CGH microarray experiments. Proceedings of the Third Euroconference on Quantitative Molecular Cytogenetics, Rosenon, Sweden, July 4–6, pp 109–114

  20. Psihramis KE, Dal Cin P, Dretler SP, Prout GR, Sanberg AA (1988) Further evidence that renal oncocytoma has malignant potential. J Urol 139:585–587

    PubMed  CAS  Google Scholar 

  21. Rothenberg DM, Brandt TD, D’Cruz I (1986) Computed tomography of renal angiomyolipoma presenting as right atrial mass. J Comput Assist Tomogr 10:1054–1056

    Article  PubMed  CAS  Google Scholar 

  22. Storkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, Darson M, Delahunt B, Iczkowski K (1997) Classification of renal carcinoma. Workgroup No. 1. Cancer 80:987–989

    Article  PubMed  CAS  Google Scholar 

  23. Yang XJ, Sugimura J, Schafernak KT, Tretiakova MS, Han M, Vogelzang NJ, Furge K, Teh BT (2006) Classification of renal neoplasms based on molecular signatures. J Urol 175:2302–2306

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Charles University Hospital Plzeň, Pilsen, Czech Republic

    Ondrej Hes, Michal Michal, Radek Šíma & Tomáš Vaněček

  2. Department of Pathology, Verona University, Verona, Italy

    Matteo Brunelli & Guido Martignoni

  3. Department of Pathology, Red Cross Hospital Kochi, Kochi, Japan

    Naoto Kuroda

  4. Department of Pathology, Centro Medico Mexico City, Mexico, USA

    Isabel Alvarado Cabrero

  5. Department of Pathology, Institute Nacional de Cancerología, Mexico City, Mexico, USA

    Delia Perez-Montiel

  6. Department of Urology, Charles University Hospital Plzeň, Pilsen, Czech Republic

    Milan Hora & Tomáš Ürge

  7. Department of Forensic Medicine, Charles University Plzeň, Pilsen, Czech Republic

    Miroslav Dvořák

  8. Department of Hematooncology, University Hospital Olomouc, Olomouc, Czech Republic

    Marie Jarošová

  9. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Ximing Yang

  10. Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty and University Hospital, Alej Svobody 80, 323 18, Pilsen, Czech Republic

    Ondrej Hes

Authors
  1. Ondrej Hes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michal Michal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Radek Šíma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomáš Vaněček
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Matteo Brunelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guido Martignoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Naoto Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Isabel Alvarado Cabrero
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Delia Perez-Montiel
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Milan Hora
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Tomáš Ürge
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Miroslav Dvořák
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Marie Jarošová
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Ximing Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ondrej Hes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hes, O., Michal, M., Šíma, R. et al. Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features. Virchows Arch 452, 193–200 (2008). https://doi.org/10.1007/s00428-007-0541-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-007-0541-1

Keywords

Search

Navigation