Skip to main content

Advertisement

Log in

COX-2 inhibitor (nimesulide) induced acute liver failure

  • Letter To The Editor
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Andrade RJ, Lucena MI, Fernandez MC, Gonzalez M (2000) Fatal hepatitis associated with nimesulide. J Hepatol 32:174

    Article  CAS  PubMed  Google Scholar 

  2. Boelsterli UA, Zimmerman HJ, Kretz-Rommel A (1995) Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology. Crit Rev Toxicol 25:207–235

    Article  CAS  PubMed  Google Scholar 

  3. Hawkey CJ (1999) Cox-2 inhibitors. Lancet 353:307–314

    Article  CAS  PubMed  Google Scholar 

  4. McCormick PA, Kennedy F, Curry M, Traynor O (1999) COX 2 inhibitor and fulminant hepatic failure. Lancet 353:40–41

    Article  CAS  PubMed  Google Scholar 

  5. Merlani G, Fox M, Oehen HP, Cathomas G, Renner EL, Fattinger K, Schneemann M, Kullak-Ublick GA (2001) Fatal hepatotoxicity secondary to nimesulide. Eur J Pharmacol 57:321–326

    Article  CAS  Google Scholar 

  6. Rainsford KD (1999) Relationship of nimesulide safety to its pharmacokinetics: assessment of adverse reactions. Rheumatology (Oxf) 38:4–10

    Article  CAS  Google Scholar 

  7. Romero-Gomez M, Nevado Santos M, Otero Fernandez MA, Fovelo MJ, Suarez-Garcia E, Castro Fernandez M (1999) Acute cholestatic hepatitis induced by nimesulide. Liver 19:164–165

    Article  CAS  PubMed  Google Scholar 

  8. Schattner A, Sokolovskaya N, Cohen J (2000) Fatal hepatitis and renal failure during treatment with nimesulide. J Intern Med 247:153–155

    Article  CAS  PubMed  Google Scholar 

  9. Van Steenbergen W, Peeters P, De Bondt J, Staessen D, Buscher H, Laporta T, Roskams T, Desmet V (1998) Nimesulide-induced acute hepatitis: evidence from six cases. J Hepatol 29:135–141

    Article  PubMed  Google Scholar 

  10. Zimmerman HJ (1990) Update of hepatotoxicity due to classes of drugs in common clinical use: non-steroidal drugs, antiinflammatory drugs, antibiotics, antihypertensives, and cardiac and psychotropic agents. Semin Liver Dis 10:322–338

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Felix A. Offner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stadlmann, S., Zoller, H., Vogel, W. et al. COX-2 inhibitor (nimesulide) induced acute liver failure. Virchows Arch 440, 553–555 (2002). https://doi.org/10.1007/s00428-002-0612-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-002-0612-2

Keywords

Navigation