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Maternal nutrition and effects on offspring vascular function

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Abstract

Maternal nutrition during pregnancy may have profound effects on the developing fetus and impact risk for cardiovascular disease later in life. Here, we provide a narrative review on the impact of maternal diet during pregnancy on offspring vascular function. We review studies reporting effects of maternal micronutrient (folic acid, iron) intakes, high-fat diets, dietary energy restriction, and low protein intake on offspring endothelial function. We discuss the differences in study design and outcomes and potential underlying mechanisms contributing to the vascular phenotypes observed in the offspring. We further highlight key gaps in the literature and identify targets for future investigations.

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This work is supported by funding from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Council of Canada. AMD is supported by an Investigator Grant from BC Children’s Hospital Research Institute.

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  1. Nicha Boonpattrawong

    Present address: BC Children’s Hospital Research Institute, Vancouver, British Columbia, Canada

Authors and Affiliations

  1. Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada

    Taylor A. Ricci & Angela M. Devlin

  2. BC Children’s Hospital Research Institute, Vancouver, British Columbia, Canada

    Taylor A. Ricci & Angela M. Devlin

  3. Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada

    Nicha Boonpattrawong

  4. Department of Anesthesiology, Pharmacology, and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada

    Ismail Laher

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TAR and AMD wrote the first draft of the manuscript. TAR prepared the figures. TAR, NB, IL, and AMD edited the manuscript and figures. All authors reviewed the final version of the manuscript.

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Correspondence to Angela M. Devlin.

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Ricci, T.A., Boonpattrawong, N., Laher, I. et al. Maternal nutrition and effects on offspring vascular function. Pflugers Arch - Eur J Physiol 475, 877–887 (2023). https://doi.org/10.1007/s00424-023-02807-x

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