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Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways

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Abstract

Our review focuses on the recent data showing that gene transcription and translation are under the control of signaling pathways triggered by modulation of the intracellular sodium/potassium ratio ([Na+]i/[K+]i). Side-by-side with sensing of osmolality elevation by tonicity enhancer-binding protein (TonEBP, NFAT5), [Na+]i/[K+]i-mediated excitation-transcription coupling may contribute to the transcriptomic changes evoked by high salt consumption. This novel mechanism includes the sensing of heightened Na+ concentration in the plasma, interstitial, and cerebrospinal fluids via augmented Na+ influx in the endothelium, immune system cells, and the subfornical organ, respectively. In these cells, [Na+]i/[K+]i ratio elevation, triggered by augmented Na+ influx, is further potentiated by increased production of endogenous Na+,K+-ATPase inhibitors documented in salt-sensitive hypertension.

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Acknowledgments

This work was supported by grants from the Canadian Institutes of Health Research, the Kidney Foundation of Canada, the Russian Foundation for Fundamental Research, and the Ministry of Science and Education of the Russian Federation. The manuscript was edited by Ovid Da Silva.

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  1. Laboratory of Biological Membranes, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1/12, Moscow, 119991, Russia

    Sergei N. Orlov

  2. Tomsk State University, Tomsk, Russia

    Sergei N. Orlov

  3. Centre de Recherche, Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada

    Pavel Hamet

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Orlov, S.N., Hamet, P. Salt and gene expression: evidence for [Na+]i/[K+]i-mediated signaling pathways. Pflugers Arch - Eur J Physiol 467, 489–498 (2015). https://doi.org/10.1007/s00424-014-1650-8

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