Abstract
Purpose
Enhanced Recovery after Surgery has been proven effective for patients with gastrointestinal cancer. But radical enhanced recovery could also lead to adverse clinical outcomes. Compared with reports on the estimation of successful implementation of enhanced recovery, studies on risk factors of enhanced recovery failure are still lacking.
Methods
A retrospective analysis was carried out on 102 patients in ERAS who underwent elective colon cancer surgery. This study included 102 patients with colon cancer between 2015 and 2019, defining enhanced recovery failure as postoperative length of stay over 10 days, stay in ICU over 24 h after surgery, reoperation, death, or unplanned readmission within 30 days after surgery. Univariate and multivariate analyses were performed to explore potential risk factors of failure.
Results
Aged ≥ 75, open operation, number of drainage tube over 1, re-urethral catheterization, and Clavien-Dindo grade over 2 were associated with ERAS failure, according to univariate analysis. Multivariate analysis showed that age ≥ 75 [OR 7.231; P = 0.009]; open operation (OR 3.599; P = 0.021); and number of drainage tube over 1 (OR 3.202; P = 0.020) were independent risk factors for ERAS failure.
Conclusions
We found age ≥ 75, open operation, and number of drainage tube over 1 are independent risk factors associated with ERAS failure after colon cancer surgery.
Similar content being viewed by others
References
Wilmore DW, Kehlet H (2001) Management of patients in fast track surgery. BMJ 322:473–476
Chestovich PJ, Lin AY, Yoo J (2003) Fast-track pathways in colorectal surgery. Surg Clin N Am 93:21–32
Bosio RM, Smith BM, Aybar PS, Senagore AJ (2007) Implementation of laparoscopic colectomy with fast-track care in an academic medical center: benefits of a fully ascended learning curve and specialty expertise. Am J Surg 193:413–415
Kehlet H, Wilmore DW (2008) Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 248:189–198
Zhuang CL, Ye XZ, Zhang XD, Chen BC, Yu Z (2013) Enhanced Recovery after Surgery programs versus traditional care for colorectal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum 56:667–678
Spanjersberg WR, Reurings J, Keus F, van Laarhoven CJHM (2011) Fast track surgery versus conventional recovery strategies for colorectal surgery. Cochrane Database Syst Rev 2:CD007635
Lassen K, Soop M, Nygren J, Cox PB, Hendry PO, Spies C, von Meyenfeldt M, Fearon KC, Revhaug A, Norderval S, Ljungqvist O, Lobo DN, Dejong CH, Enhanced Recovery After Surgery (ERAS) Group (2009) Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery after Surgery (ERAS) group recommendations. Arch Surg 144:961–969
Feroci F, Lenzi E, Baraghini M, Garzi A, Vannucchi A, Cantafio S, Scatizzi M (2013) Fast-track surgery in real life: how patient factors influence outcomes and compliance with an enhanced recovery clinical pathway after colorectal surgery. Surg Laparosc Endosc Percutan Tech 23:259–265
Smart NJ, White P, Allison AS, Ockrim JB, Kennedy RH, Francis NK (2012) Deviation and failure of Enhanced Recovery after Surgery following laparoscopic colorectal surgery: early prediction model. Color Dis 14:727–734
Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213
Lewis DR, Chen HS, Cockburn MG, Wu XC, Stroup AM, Midthune DN, Zou Z, Krapcho MF, Miller DG, Feuer EJ (2017) Early estimates of SEER cancer incidence, 2014. Cancer 123:2524–2534
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71–96
Alley PG (2000) Surgery for colorectal cancer in elderly patients. Lancet 356:956
Temple LK, Hsieh L, Wong WD et al (2004) Use of surgery among elderly patients with stage IV colorectal cancer. J Clin Oncol 22:3475–3484
Papamichael D, Audisio R, Horiot JC, Glimelius B, Sastre J, Mitry E, van Cutsem E, Gosney M, Köhne CH, Aapro M, SIOG (2009) Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol 20:5–16
Yamamoto S, Hinoi T, Niitsu H et al (2017) Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer: subanalysis of a large multicenter study in Japan. J Gastroenterol 52:695–704
Jafari MD, Jafari F, Halabi WJ, Nguyen VQ, Pigazzi A, Carmichael JC, Mills SD, Stamos MJ (2014) Colorectal cancer resections in the aging US population a trend toward decreasing rates and improved outcomes. JAMA Surg 149:557–564
Wagman LD (2007) Laparoscopic and open surgery for colorectal cancer: reaching equipoise? J Clin Oncol 25:2996–2998
Greene FL (1999) Laparoscopic management of colorectal cancer. CA Cancer J Clin 49:221–228
Marcello PW (2000) Laparoscopic colorectal surgery. Gastroenterology 118:806
Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, Haglind E, Påhlman L, Cuesta MA, Msika S, Morino M, Lacy AM, COlon cancer Laparoscopic or Open Resection Study Group (COLOR) (2005) Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 6:477–484
Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G (2002) Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. JAMA 287:321–328
Nelson H, Sargent DJ, Wieand HS et al (2004) A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 350:2050–2059
Buunen M, Veldkamp R, Hop WC et al (2009) Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial. Lancet Oncol 10:44–52
Sun J, Qiu ZJ (2011) A non-randomized perspective investigation on long-term outcomes comparison between laparoscopic and open surgery in the treatment of colon cancer. Fudan Univ J Med Sci 03:211–215
Kennedy RH, Francis EA, Wharton R, Blazeby JM, Quirke P, West NP, Dutton SJ (2014) Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme: EnROL. J Clin Oncol 32:1804–1812
Robinson JO (1986) Surgical drainage: an historical perspective. Br J Surg 73:422–426
Sagar PM, Couse N, Kerin M, May J, Macfie J (1993) Randomized trial of drainage of colorectal anastomosis. Br J Surg 80:769–771
Tsujinaka S, Konishi F (2011) Drain vs no drain after colorectal surgery. Indian J Surg Oncol 2:3–8
Rondelli F, Bugiantella W, Vedovati MC et al (2014) To drain or not to drain extraperitoneal colorectal anastomosis? A systematic review and meta-analysis. Color Dis 16:35–42
Urbach DR, Kennedy ED, Cohen MM et al (1999) Colon and rectal anastomoses do not require routine drainage. Ann Surg 229:174–180
Petrowsky H, Demartines N, Rousson V, Clavien PA (2004) Evidence-based value of prophylactic drainage in gastrointestinal surgery. Ann Surg 240:1074–1084
Foster ME (2017) To drain or not after colorectal surgery. Ann R CON Surg Engl 70:158–160
Emile SH, Abd El-Hamed TM (2017) Routine drainage of colorectal anastomoses: an evidence-based review of the current literature. Gastroenterol Res Pract 2017:1–7
Schreiber A, Aydil E, Walschus U, Glitsch A, Patrzyk M, Heidecke C-D, Schulze T (2019) Early removal of urinary drainage in patients receiving epidural analgesia after colorectal surgery within an ERAS protocol is feasible. Langenbeck's Arch Surg 404:853–863
Sun SD, Wu PP, Zhou JF, Wang JX, He QL (2020) Failure of Enhanced Recovery after Surgery in laparoscopic colorectal surgery: a systematic review. Int J Color Dis 35:1007–1014
Crouzet J, Bertrand X, Venier AG, Badoz M, Husson C, Talon D (2007) Control of the duration of urinary catheterization: impact on catheter-associated urinary tract infection. J Hosp Infect 67:253–257
Collard MK, Anyla M, Lefevre JH et al (2020) Patients’ refusal as major limitation of early discharge after colorectal resection in an enhanced recovery program. Langenbeck's Arch Surg 405:337–344
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Chen, JS., Sun, SD., Wang, ZS. et al. The factors related to failure of Enhanced Recovery after Surgery (ERAS) in colon cancer surgery. Langenbecks Arch Surg 405, 1025–1030 (2020). https://doi.org/10.1007/s00423-020-01975-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00423-020-01975-z