Skip to main content
SpringerLink
Log in

Biophysical model of synaptic plasticity dynamics

  • Published:
Biological Cybernetics Aims and scope Submit manuscript

Abstract.

We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca2+ release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Acknowledgments.

We are very grateful to A. Selverston, D. Feldman, and C. Stevens for conversations about this work. This work was partially supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Engineering and Geosciences, under Grant No. DE-FG03-90ER14138 and No. DE-FG03-96ER14592, by Grant NSF PHY0097134 from the National Science Foundation, by Grant DAAD19-01-1-0026 from the Army Research Office, by Grant N00014-00-1-0181 from the Office of Naval Research, and by Grant NIH R01 NS40110-01A2 from the National Institutes of Health. Also, this work was partially supported by M. Ciencia y Tecnología BFI2000-0157 (R. H.).

Author information

Authors and Affiliations

  1. Institute for Nonlinear Science, Center for Theoretical Biological Physics, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego La Jolla, CA 93093-0402, USA

    Henry D. I. Abarbanel

  2. Institute for Nonlinear Science, University of California, San Diego La Jolla, CA 92093-0402, USA

    Leif Gibb, R. Huerta & M. I. Rabinovich

Authors
  1. Henry D. I. Abarbanel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leif Gibb
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Huerta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. I. Rabinovich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henry D. I. Abarbanel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abarbanel, H., Gibb, L., Huerta, R. et al. Biophysical model of synaptic plasticity dynamics. Biol. Cybern. 89, 214–226 (2003). https://doi.org/10.1007/s00422-003-0422-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00422-003-0422-x

Keywords

Search

Navigation