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Four years of corneal keratoplasty in Italian paediatric patients: indications and clinical outcomes

  • Pediatrics
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Abstract

Purpose

The purpose was to evaluate indications and clinical outcomes in paediatric corneal keratoplasty.

Methods

Fifty-four eyes of 43 patients who underwent corneal keratoplasty from the 1st of January 2010 through the 31st of December 2013 at the Bambino Gesù Children’s Hospital in Rome, Italy, were retrospectively evaluated. To assess the effect of age on graft failure rate, the recipient age was considered as a dichotomous variable (≤5 or >5 years) and a 2X2 table was developed, using the chi-square test for testing the statistical significance. Furthermore, two separate subgroup analyses were conducted on patients of ≤5 years and those of >5 years, to evaluate the effect of penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty (DALK) on the graft failure rate. The level of statistical significance was set at p < 0.05

Results

Mean recipient age was 8.9 ± 5.7 [SD] years. Mean follow-up time was 22.8 months. Main preoperative diagnoses were keratoconus (37 %) and congenital glaucoma (20 %). Patients ≤5 years showed a higher percentage of graft failure (p = 0.0008). PK and DALK did not show statistically significant differences regarding the graft failure in both subgroups (p = 0.15 for ≤5 years group and p = 0.27 for >5 years group, respectively). However, across groups DALK provided a lower rate of graft failure.

Conclusions

Our findings suggest that children older than 5 years show a significantly better graft outcome and that DALK seems to offer greatest benefits in terms of failure risk in paediatric patients.

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Acknowledgments

The authors have no financial or proprietary interests in this study.

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Authors and Affiliations

  1. Ophthalmology Department, Bambino Gesù IRCCS Children’s Hospital, Via Torre di Palidoro snc – 00050, Passoscuro, Roma, Italy

    Luca Buzzonetti, Sergio Petroni, Gianni Petrocelli, Paola Valente, Rosa Parrilla & Giancarlo Iarossi

  2. Institute of Ophthalmology, Catholic University, Rome, Italy

    Luca Buzzonetti

  3. Institute of Ophthalmology, Tor Vergata University, Rome, Italy

    Roberta Ardia

Authors
  1. Luca Buzzonetti
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  2. Roberta Ardia
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  3. Sergio Petroni
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  4. Gianni Petrocelli
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  5. Paola Valente
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  6. Rosa Parrilla
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  7. Giancarlo Iarossi
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Corresponding author

Correspondence to Luca Buzzonetti.

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Funding

No funding was received for this research

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

The following sentence: “For this data analysis formal consent is not required, whereas informed consent for the surgical procedure was obtained from all individual participants included in the study” has been added.

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Buzzonetti, L., Ardia, R., Petroni, S. et al. Four years of corneal keratoplasty in Italian paediatric patients: indications and clinical outcomes. Graefes Arch Clin Exp Ophthalmol 254, 2239–2245 (2016). https://doi.org/10.1007/s00417-016-3447-2

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  • DOI: https://doi.org/10.1007/s00417-016-3447-2

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