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Butyrylcholinesterase K variant and Alzheimer’s disease

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Abstract

This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer’s disease. This was performed on an autopsy-confirmed series of patients with Alzheimer’s disease and controls. The butyrylcholinesterase K variant was found to be of increased allele frequency in patients with sporadic Alzheimer’s disease. When related to APOE ɛ4 typing the association was specific but not sensitive for the diagnosis of Alzheimer’s disease.

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Authors and Affiliations

  1. Department of Neuropathology, Royal Perth Hospital, Wellington Street, AUS-Perth 6000, Australia Fax: +618-92242556, , , , , , AU

    P. K. Panegyres, Vicki Fabian & Byron A. Kakulas

  2. Department of Clinical Biochemistry, Royal Perth Hospital, Wellington Street, AUS-Perth 6000, Australia, , , , , , AU

    Cyril D. S. Mamotte & Sam D. Vasikaran

  3. Australian Neuromuscular Research Institute, AUS-Perth 6000, Australia, , , , , , AU

    Steve Wilton

Authors
  1. P. K. Panegyres
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  2. Cyril D. S. Mamotte
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  3. Sam D. Vasikaran
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  4. Steve Wilton
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  5. Vicki Fabian
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  6. Byron A. Kakulas
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Additional information

Received: 9 June 1998 Received in revised form: 15 September 1998 Accepted: 26 September 1998

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Panegyres, P., Mamotte, C., Vasikaran, S. et al. Butyrylcholinesterase K variant and Alzheimer’s disease. J Neurol 246, 369–370 (1999). https://doi.org/10.1007/s004150050365

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  • DOI: https://doi.org/10.1007/s004150050365

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