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The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

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Abstract

Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A “Pinch-Grip” apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.

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Acknowledgments

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A090632), a grant of the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A1064752), by the Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 2011-0028333 & 2010-0014026), by Samsung Biomedical Research Institute grants (C-B0-217-3), and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &Welfare, Republic of Korea (HI14C3484).

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Authors and Affiliations

  1. Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea

    Geon Ha Kim & Jee Hyang Jeong

  2. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Geon Ha Kim, Sang Won Seo, Byung Hwa Lee, Doo Sang Yoon & Duk L. Na

  3. Ewha Brain Institute, Ewha Womans University, Seoul, Korea

    Geon Ha Kim

  4. Neuroscience Center, Samsung Medical Center, Seoul, Korea

    Sang Won Seo, Byung Hwa Lee, Doo Sang Yoon & Duk L. Na

  5. Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea

    Sang Won Seo

  6. School of Industrial Engineering, University of Ulsan, Ulsan, Korea

    Kihyo Jung

  7. Department of Biomedical Engineering, Hanyang University, Seoul, Korea

    Oh-Hun Kwon, Hunki Kwon & Jong Min Lee

  8. Department of Neurology, National Health Insurance Corporation, Ilsan Hospital, Goyang, Korea

    Jong Hun Kim

  9. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Jee Hoon Roh

  10. Department of Neurology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea

    Min-Jeong Kim

  11. Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea

    Jung Won Hwang

  12. Department of Industrial and Management Engineering, Pohang University of Science and Technology, Pohang, Korea

    Heecheon You

  13. Department of Neurology, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Gainesville, FL, USA

    Kenneth M. Heilman

  14. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea

    Duk L. Na

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  1. Geon Ha Kim
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Corresponding author

Correspondence to Duk L. Na.

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Ethical standards

Informed consent was obtained from all participants. The study protocol was approved by the Institutional Review Board of Samsung Medical Center.

Conflicts of interest

G. H. Kim, K. Jung, O. Kwon, H. Kwon, B. H. Lee, D. S. Yoon and J. W. Hwang report no disclosures. S. W. Seo, MD, J. H. Kim, J. H. Roh, M. J. Kim, J. H. Jeong, J. M. Lee, H. You and K. Heilman report no disclosures. D. L. Na reports no disclosures.

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Kim, G.H., Seo, S.W., Jung, K. et al. The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment. J Neurol 263, 89–99 (2016). https://doi.org/10.1007/s00415-015-7946-6

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