Skip to main content
SpringerLink
Log in

Stiff person syndrome (SPS) complicated by respiratory failure: successful treatment with rituximab

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Martino G, Grimaldi LM, Bazzigaluppi E, Passini N, Sinigaglia F, Rogge L (1996) The insulin-dependent diabetes mellitus-associated ICA 105 autoantigen in stiff-man syndrome patients. J Neuroimmunol 69(1–2):129–134 [Medline]

    Article  PubMed  CAS  Google Scholar 

  2. Lohmann T, Hawa M, Leslie RD, Lane R, Picard J, Londei M (2000) Immune reactivity to glutamic acid decarboxylase 65 in Stiffman syndrome and type 1 diabetes mellitus. Lancet 356(9223):31–35 [Medline]

    Article  PubMed  CAS  Google Scholar 

  3. Ellis TM, Atkinson MA (1996) The clinical significance of an autoimmune response against glutamic acid decarboxylase. Nat Med 2(2):148–153 [Medline]

    Article  PubMed  CAS  Google Scholar 

  4. O’Sullivan EP, Behan LA, King TF, Hardiman O, Smith D (2009) A case of stiff-person syndrome, type 1 diabetes, Celiac disease and Dermatitis herpetiformis. Clin Neurol Neurosurg 111(4):384–386 [Medline]

    Article  PubMed  Google Scholar 

  5. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P (1990) Auoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322(22):1555–1560

    Article  PubMed  CAS  Google Scholar 

  6. Solimena M, De Camilli P (1991) Autoimmunity to glutamic acid decarboxylase (GAD) in stiffman syndrome and insulin-dependent diabetes mellitus. Trends Neurosci 14(10):452–457

    Article  PubMed  CAS  Google Scholar 

  7. Feske S, Samuels M (Eds) McEvoy, K. (1996) Stiff-man syndrome. In: Office practice of neurology. Churchill-Livingstone, New York, 1996, Ch. 130

  8. Göppert D, Gardill K, Beischer W, Wiethölter H, Medizinische Klinik 3, Bürgerhospital Stuttgart (2000) The stiff-man syndrome with diabetes mellitus type 1 and autoimmune thyroiditis. Dtsch Med Wochenschr 125(27):826–829

    Article  PubMed  Google Scholar 

  9. Dalakas MC, Fujii M, Li M, Lutfi B, Kyhos J, McElroy B (2001) High-dose intravenous immune globulin for stiff-person syndrome. N Engl J Med 345(26):1870–1876

    Article  PubMed  CAS  Google Scholar 

  10. Karlson EW, Sudarsky L, Ruderman E et al (1994) Treatment of stiff-man syndrome with intravenous immune globulin. Arthritis Rheum 37:915

    Article  PubMed  CAS  Google Scholar 

  11. Brashear HR, Phillips LH II (1991) Autoantibodies to GABAergic neurons and response to plasmapheresis in Stiff-man syndrome. Neurology 41(10):1588–1592

    PubMed  CAS  Google Scholar 

  12. Rakocevic G, Raju R, Dalakas MC (2004) Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch Neurol 61(6):902–904

    Article  PubMed  Google Scholar 

  13. Saidha S, Elamin M, Mullins G, Chaila E, Tormey VJ, Hennessy MJ (2008) Treatment of progressive encephalomyelitis with rigidity and myoclonic jerks with rituximab. PMID: 18394044 [PubMed]

  14. Baker MR, Das M, Isaacs J, Fawcett PR, Bates D (2005) Treatment of stiff person syndrome with rituximab. J Neurol Neurosurg Psychiatry 76(7):999–1001

    Article  PubMed  CAS  Google Scholar 

  15. Bethesda, MD; National Institutes of Health: Rituximab to Treat Stiff Person Syndrome. [http://clinicaltrials.gov/ct2/show/NCT00091897] ClinicalTrials.gov Identifier: NCT00091897

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Neurology, University College Hospital Galway, Galway, Republic of Ireland

    A. Qureshi & M. Hennessy

Authors
  1. A. Qureshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Hennessy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Qureshi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Qureshi, A., Hennessy, M. Stiff person syndrome (SPS) complicated by respiratory failure: successful treatment with rituximab. J Neurol 259, 180–181 (2012). https://doi.org/10.1007/s00415-011-6123-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-011-6123-9

Keywords

Search

Navigation