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Midbrain atrophy in subcortical ischemic vascular dementia

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Abstract

Magnetic resonance imaging (MRI) has revealed age-related changes in midbrain volume in normal subjects. Atrophy of the midbrain in patients with progressive supranuclear palsy (PSP) has been demonstrated using conventional brain MRI, and it was recently reported that some patients with vascular dementia also have midbrain atrophy. The aim of the present study was to investigate if the patients with subcortical ischemic vascular dementia (SIVD) have atrophic changes in the midbrain. MRIs of 23 SIVD patients, 18 probable PSP patients, and 96 controls were retrospectively analyzed. Differences in the distances between midbrain structures were compared across the patient groups and controls. We measured the anteroposterior diameter (AP), and the distance between the interpeduncular fossa and the aqueduct (IF–AQ), the aqueduct and posterior margin of the superior colliculi (AQ–SC), and the peduncular prominence and the interpeduncular fossa (PP–IF) of the midbrain. The AP diameter and IF–AQ were negatively correlated with age in normal controls (r = −0.21, p < 0.005 for AP; r = −0.14, p < 0.0001 for IF–AQ). In SIVD patients, the AP diameter and IF–AQ were both significantly smaller than in controls (p < 0.001). Changes in the midbrain found for SIVD patients were similar to those seen in PSP patients. Our results suggest that the midbrain decreases in size with normal aging, especially around the tegmental region. This change is more pronounced in patients with SIVD and in patients with PSP. Prospective functional studies are needed to ascertain the clinical relevance of midbrain atrophy in SIVD.

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Acknowledgments

This study was supported by a grant for the Korea Health 21 R&D Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea (A050079). The authors thank Dr. Kurt Jellinger for his help in critically reviewing the manuscript.

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Authors and Affiliations

  1. Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea

    Young-Hee Sung, Ki-Hyung Park, Yeung-Bae Lee, Hyeon-Mi Park & Dong Jin Shin

  2. Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 1605-4 Gwanyang-dong, Dongan-gu, Anyang-si, Gyeonggi-do, 431-061, Korea

    Jea-Sul Park, Mi-Sun Oh, Hyeo-Il Ma, Kyung-Ho Yu, Suk-Yun Kang, Yun Joong Kim & Byung-Chul Lee

  3. ILSONG Institute of Life Science, Hallym University, Anyang, Korea

    Yun Joong Kim

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  1. Young-Hee Sung
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Correspondence to Yun Joong Kim.

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Sung, YH., Park, KH., Lee, YB. et al. Midbrain atrophy in subcortical ischemic vascular dementia. J Neurol 256, 1997–2002 (2009). https://doi.org/10.1007/s00415-009-5226-z

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  • DOI: https://doi.org/10.1007/s00415-009-5226-z

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