Abstract
Invasive treatment for Gilles de la Tourette syndrome has shown interesting results in a number of published reports; it seems to be evolving into a promising therapeutic procedure for those patients demonstrating disabling clinical pictures who are refractory to conservative treatments. There are important issues concerning the stimulated brain target, with different nuclei currently under investigation. Our group asked in this pilot study whether Tourette syndrome could be treated by tailoring specific brain targets for specific symptoms. Deep brain stimulation for Tourette syndrome may thus in the future be tailored and patient specific, utilizing specific target regions for individual clinical manifestations. In our early experience we did not adequately address non-motor clinical symptoms as we only used a thalamic target. More recently in an obsessive compulsive disease cohort we have had success in using the anterior limb of the internal capsule and nucleus accumbens region as targets for stimulation. We therefore explored the option of a “rescue” procedure for our Tourette patients with persistent obsessive-compulsive disorder following ventralis oralis/centromedianus-parafascicularis (Vo/CM-Pf) deep brain stimulation. Following two cases where rescue anterior limb of internal capsule/nucleus accumbens leads were employed, we performed two additional procedures (anterior limb of the internal capsule plus ventralis oralis/centromedianus-parafascicularis and anterior limb of the internal capsule alone) with some mild improvement of comorbid obsessive–compulsive disorder, although the number of observations in this case series was low. Overall, the effects observed with using the anterior limb of the internal capsule either alone or as a rescue were less than expected. In this report we detail our experience with this approach.
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Lujan JL, Chaturvedi A, McIntyre CC (2008) Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. Front Biosci 13:5892–5904. doi:10.2741/3124
Larson PS Neurotherapeutics 2008 Deep brain stimulation for psychiatric disorders, vol 5. No. 1
Greenberg BD, Askland KD, Carpenter LL (2008) The evolution of deep brain stimulation for neuropsychiatric disorders. Front Biosci 13:4638–4648. doi:10.2741/3029
Kopell BH, Greenberg BD (2008) Anatomy and physiology of the basal ganglia: implications for DBS in psychiatry. Neurosci Biobehav Rev 32(3):408–422. doi:10.1016/j.neubiorev.2007.07.004 (review)
Wichmann T, Delong MR (2006) Deep brain stimulation for neurologic and neuropsychiatric disorders. Neuron 52(1):197–204. doi:10.1016/j.neuron.2006.09.022 (review)
Giacobbe P, Kennedy SH (2006) Deep brain stimulation for treatment-resistant depression: a psychiatric perspective. Curr Psychiatry Rep 8(6):437–444. doi:10.1007/s11920-006-0048-5 (review)
Aouizerate B, Cuny E, Martin-Guehl C, Guehl D, Amieva H, Benazzouz A, Fabrigoule C, Allard M, Rougier A, Bioulac B, Tignol J, Burbaud P (2004) Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive–compulsive disorder and major depression. Case report. J Neurosurg 101(4):682–686
Brito GN (1997) A neurobiological model for Tourette syndrome centered on the nucleus accumbens. Med Hypotheses 49(2):133–142. doi:10.1016/S0306-9877(97)90218-8
Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, Klosterkotter J (2003) The nucleus accumbens: a target for deep brain stimulation in obsessive–compulsive- and anxiety-disorders. J Chem Neuroanat 26(4):293–299. doi:10.1016/j.jchemneu.2003.09.003 (review)
Greenberg BD, Gabriels LA, Malone DA Jr, Rezai AR, Friehs GM, Okun MS, Shapira NA, Foote KD, Cosyns PR, Kubu CS, Malloy PF, Salloway SP, Giftakis JE, Rise MT, Machado AG, Baker KB, Stypulkowski PH, Goodman WK, Rasmussen SA, Nuttin BJ (2008) Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive–compulsive disorder: worldwide experience. Mol Psychiatry [Epub ahead of print]
Okun MS, Mann G, Foote KD, Shapira NA, Bowers D, Springer U, Knight W, Martin P, Goodman WK (2007) Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming. J Neurol Neurosurg Psychiatry 78(3):310–314. doi:10.1136/jnnp.2006.095315
Greenberg BD, Malone DA, Friehs GM, Rezai AR, Kubu CS, Malloy PF, Salloway SP, Okun MS, Goodman WK, Rasmussen SA (2006) Three-year outcomes in deep brain stimulation for highly resistant obsessive–compulsive disorder. Neuropsychopharmacology 31(11):2384–2393. doi:10.1038/sj.npp.1301165 (Erratum in: Neuropsychopharmacology. 31 November 2006 11:2394)
Rauch SL, Dougherty DD, Malone D, Rezai A, Friehs G, Fischman AJ, Alpert NM, Haber SN, Stypulkowski PH, Rise MT, Rasmussen SA, Greenberg BD (2006) A functional neuroimaging investigation of deep brain stimulation in patients with obsessive–compulsive disorder. J Neurosurg 104(4):558–565. doi:10.3171/jns.2006.104.4.558
Houeto JL, Karachi C, Mallet L, Pillon B, Yelnik J, Mesnage V, Welter ML, Navarro S, Pelissolo A, Damier P, Pidoux B, Dormont D, Cornu P, Agid Y (2005) Tourette’s syndrome and deep brain stimulation. J Neurol Neurosurg Psychiatry 76(7):992–995. doi:10.1136/jnnp.2004.043273
Foote KD, Seignourel P, Fernandez HH, Romrell J, Whidden E, Jacobson C, Rodriguez RL, Okun MS (2006) Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor. Neurosurgery 58(4)(Suppl 2):ONS-280–ONS-285 (discussion ONS-285–ONS-286)
Foote KD, Okun MS (2005) Ventralis intermedius plus ventralis oralis anterior and posterior deep brain stimulation for posttraumatic Holmes tremor: two leads may be better than one: technical note. Neurosurgery 56(2(Suppl)):445. doi:10.1227/01.NEU.0000157104.87448.78 discussion E445
Welter ML, Mallet L, Houeto JL, Karachi C, Czernecki V, Cornu P, Navarro S, Pidoux B, Dormont D, Bardinet E, Yelnik J, Damier P, Agid Y (2008) Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol 65(7):952–957. doi:10.1001/archneur.65.7.952
Ackermans L, Temel Y, Cath D, van der Linden C, Bruggeman R, Kleijer M, Nederveen P, Schruers K, Colle H, Tijssen MA, Visser-Vandewalle V (2006) Dutch Flemish Tourette Surgery Study Group. Deep brain stimulation in Tourette’s syndrome: two targets? Mov Disord 21(5):709–713. doi:10.1002/mds.20816
De Boer AG, Van Lanschot JJ, Stalmeier PF, Van Sandick JW, Hulscher JB, De Haes JC, Sprangers MA (2004) Is a single-item visual analogic scale as valid, reliable and responsive as multi-item scales in measuring quality of life? Qual Life Res 13(2):311–320. doi:10.1023/B:QURE.0000018499.64574.1f
Beck AT, Rush AI, Shaw BF, Emery G (1987) Terapia cognitiva della depressione Boringhieri, Torino
Bertolotti G, Michelin P, Sanavio E, Simonetti G, Vidotto G, Zotti AM “CBA 2.0 Cognitive Behavioural Assessment” 1987 (4th edn) “Organizzazioni Speciali” Firenze
Goodman WK, price LH, rasmussen SA (1989) The Yale-Brown Obsessive Compulsive Scale: I. Development, use and reliability. Arch Gen Psychiatry 46(11):1006–1011
Goodman WK, Price LH, Rasmussen SA (1989) The Yale-Brown Obsessive Compulsive Scale: II. Validity. Arch Gen Psychiatry 46(11):1012–1016
Leckman JF, Riddle MA, Hardin MT (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of severity. Am Acad Child Adolesc Psychiatry 28:566–573. doi:10.1097/00004583-198907000-00015
Robertson MM, Banerjee S, Kurlan R, Cohen DJ, Leckman JF, McMahon W, Pauls DL, Sandor P, van de Wetering BJ (1999) The Tourette syndrome diagnostic confidence index: development and clinical associations. Neurology 53(9):2108–2112
Porta M, Sassi M, Cavallazzi M, Fornari M, Brambilla A, Servello D (2008) Tourette’s syndrome and role of tetrabenazine : review and personal experience. Clin Drug Investig 28(7):443–459. doi:10.2165/00044011-200828070-00006
American psychiatric association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. APA, Washington DC. Text revised (DSM-IV-TR)
Servello D, Porta M, Sassi M, Brambilla A, Robertson MM (2008) Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. J Neurol Neurosurg Psychiatry 79(2):136–142. doi:10.1136/jnnp.2006.104067
Nuttin BJ, Gabriels LA, Cosyns PR et al (2003) Long-term electrical capsular stimulation in patients with obsessive–compulsive disorder. Neurosurgery 52:1263–1272. doi:10.1227/01.NEU.0000064565.49299.9A (discussion 1272–1264)
Flaherty AW, Williams ZM, Amirnovin R, Kasper E, Rauch SL, Cosgrove GR, Eskandar EN (2005) Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery 57(4(Suppl)):E403. doi:10.1227/01.NEU.0000176854.24694.95 (discussion E403)
Kuhn J, Lenartz D, Mai JK, Huff W, Lee SH, Koulousakis A, Klosterkoetter J, Sturm V (2007) Deep brain stimulation of the nucleus accumbens and the internal capsule in therapeutically refractory Tourette-syndrome. J Neurol 254(7):963–965
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The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. We wish also to acknowledge Ms. Olga Lee Rachello for English language supervision.
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Servello, D., Sassi, M., Brambilla, A. et al. De novo and rescue DBS leads for refractory Tourette syndrome patients with severe comorbid OCD: a multiple case report. J Neurol 256, 1533–1539 (2009). https://doi.org/10.1007/s00415-009-5159-6
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DOI: https://doi.org/10.1007/s00415-009-5159-6