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Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation

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References

  1. Rogaeva EA, Fafel KC, Song YQ, Medeiros H, Sato C, Liang Y, Richard E, Rogaev EI, Frommelt P, Sadovnick AD, Meschino W, Rockwood K, Boss MA, Mayeux R, St George-Hyslop P (2001) Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations. Neurology 57:621–625

    PubMed  CAS  Google Scholar 

  2. Raux G, Guyant-Marechal L, Martin C, Bou J, Penet C, Brice A, Hannequin D, Frebourg T, Campion D (2005) Molecular diagnosis of autosomal dominant early onset Alzheimer’s disease: an update. J Med Genet 42:793–795. doi:10.1136/jmg.2005.033456

    Article  PubMed  CAS  Google Scholar 

  3. Ikeuchi T, Kaneko H, Miyashita A, Nozaki H, Kasuga K, Tsukie T, Tsuchiya M, Imamura T, Ishizu H, Aoki K, Ishikawa A, Onodera O, Kuwano R, Nishizawa M (2008) Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations. Dement Geriatr Cogn Disord 26:43–49. doi:10.1159/000141483

    Article  PubMed  CAS  Google Scholar 

  4. Larner AJ, Doran M (2006) Clinical phenotypic heterogeneity of Alzheimer’s disease associated with mutations of the presenilin-1 gene. J Neurol 253:139–158. doi:10.1007/s00415-005-0019-5

    Article  PubMed  CAS  Google Scholar 

  5. Kim KW, Lee DY, Jhoo JH, Youn JC, Suh YJ, Jun YH, Seo EH, Woo JI (2005) Diagnostic accuracy of mini-mental status examination and revised hasegawa dementia scale for Alzheimer’s disease. Dement Geriatr Cogn Disord 19:324–333. doi:10.1159/000084558

    Article  PubMed  CAS  Google Scholar 

  6. Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS (2003) Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of γ-secretase. J Biol Chem 278:7010–70187. doi:10.1074/jbc.M209252200

    Article  PubMed  CAS  Google Scholar 

  7. Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T (2007) Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 associated with familial Lewy body disease and variant Alzheimer’s disease. J Neurosci 27:13092–13097. doi:10.1523/JNEUROSCI.4244-07.2007

    Article  PubMed  CAS  Google Scholar 

  8. Tedde A, Forleo P, Nacmias B, Piccini C, Bracco L, Piacentini S, Sorbi S (2000) A presenilin-1 mutation (Leu392Pro) in a familial AD kindred with psychiatric symptoms at onset. Neurology 55:1590–1591

    PubMed  CAS  Google Scholar 

  9. Harvey RJ, Ellison D, Hardy J, Mutton M, Roques PK, Collinge J, Fox NC, Rossor MN (1998) Chromosome 14 familial Alzheimer’s disease: the clinical and neuropathological characteristics of a family with a leucine → serine (L250S) substitution at codon 250 of the presenilin 1 gene. J Neurol Neurosurg Psychiatr 64:44–49. doi:10.1136/jnnp.64.1.44

    Article  PubMed  CAS  Google Scholar 

  10. Ringman JM, Diaz-Olavarrieta C, Rodriguez Y, Chavez M, Paz F, Murrell J, Macias MA, Hill M, Kawas C (2004) Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin. J Neurol Neurosurg Psychiatr 75:500–502. doi:10.1136/jnnp.2002.005025

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This study was supported in part by a Grant-in-Aid for Scientific Research (20590990) from MEXT, Japan and Kanehara Ichiro Memorial Foundation

Conflict of interest statement

The authors have reported no conflicts of interest.

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Authors and Affiliations

  1. Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan

    Kensaku Kasuga, Tomohiko Ishihara, Osamu Onodera & Takeshi Ikeuchi

  2. Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

    Kensaku Kasuga, Tomohiko Ishihara & Masatoyo Nishizawa

  3. Department of Neurology, Nagaoka Chuo General Hospital, Nagaoka, Japan

    Tsukasa Ohno

  4. Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan

    Akinori Miyashita & Ryozo Kuwano

Authors
  1. Kensaku Kasuga
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  2. Tsukasa Ohno
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  3. Tomohiko Ishihara
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  4. Akinori Miyashita
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  5. Ryozo Kuwano
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  6. Osamu Onodera
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  7. Masatoyo Nishizawa
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  8. Takeshi Ikeuchi
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Corresponding author

Correspondence to Takeshi Ikeuchi.

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Kasuga, K., Ohno, T., Ishihara, T. et al. Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation. J Neurol 256, 1351–1353 (2009). https://doi.org/10.1007/s00415-009-5096-4

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  • DOI: https://doi.org/10.1007/s00415-009-5096-4

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