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Neuropsychological consequences of endarterectomy and endovascular angioplasty with stent placement for treatment of symptomatic carotid stenosis

A prospective randomised study

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Abstract

Background and purpose

Previous studies compared carotid endarterectomy (CEA) and carotid artery stent placement (CAS) for treatment of symptomatic carotid artery stenosis. Whereas most previous studies showed both treatment modalities to be associated with a comparable risk of periprocedural cerebrovascular complications, these previous studies have shown significantly more microemboli and significantly more lesions in diffusion-weighted MR imaging after CAS compared to CEA. The clinical relevance of these differences remains unknown.We therefore compared the neuropsychological consequences of CAS and CEA and additionally measured the S100β protein, a marker of cerebral damage.

Methods

A total of 48 patients with symptomatic carotid artery stenosis greater than 70 % (according to ECST criteria) were enrolled and 45 patients participated in the follow-up. The patients were randomly assigned for CEA (24 patients) or CAS (21 patients). S100β protein values were evaluated 2 hours before the procedure, as well as one and two hours thereafter. Patients were assessed before treatment, and again 6 and 30 days after treatment using a comprehensive neuropsychological test battery.

Results

Patients of the CAS and the CEA groups did not significantly differ in terms of age, gender, education, degree of carotid artery stenosis, cerebrovascular symptoms and vascular risk factors. Following previously used criteria, a cognitive change in patients was assumed to have occurred when there was a decline of more than one standard deviation in two or more tests assessing various cognitive domains. Six days and 30 days after the treatment both groups showed a comparable number of patients with cognitive changes compared to baseline. There were no significant differences in S100β protein values.

Conclusion

These results provide some reassurance that CAS is not associated with greater cognitive deterioration than CEA is.

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Authors and Affiliations

  1. Dept. of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105, Kiel, Germany

    K. Witt MD, K. Börsch MD, C. Daniels MD, G. Deuschl MD & R. Stingele MD

  2. Dept. of Cardiovascular Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

    K. Walluscheck MD

  3. Section Neuroradiology of the Department of Neurosurgery, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

    K. Alfke MD & O. Jansen MD

  4. Dept. of Nuclear Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

    N. Czech MD

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  1. K. Witt MD
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Witt, K., Börsch, K., Daniels, C. et al. Neuropsychological consequences of endarterectomy and endovascular angioplasty with stent placement for treatment of symptomatic carotid stenosis. J Neurol 254, 1524–1532 (2007). https://doi.org/10.1007/s00415-007-0576-x

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  • DOI: https://doi.org/10.1007/s00415-007-0576-x

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