Abstract
Hypnic headache is a rare form of primary headache with attacks occurring exclusively with sleep. As it is typical of the elderly, a wide range of alternative diagnosis must be considered. We present a case report of a 54-year-old woman with unsuspected secondary hypnic headache that was relieved by anti-hypertensive therapy. We reviewed the literature to evaluate the usual diagnostic workup performed in hypnic headache patients. We suggest that 24 h ambulatory blood pressure monitoring may be included in the evaluation of nocturnal headache complaints especially in the elderly, in whom essential hypertension is a very frequent comorbidity.
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References
Evers S, Goadsby PJ (2003) Hypnic headache—a literature review on clinical features, pathophysiology, treatment. Neurology 60:905-09
Headache Classification Committee of The International Headache Society (2004) The international classification of headache disorders, 2nd edn. Cephalalgia 24:1-60
Goadsby PJ, Lipton RB (1997) A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic features, including new cases. Brain 120:193-09
Lance JW, Goadsby PJ (2005) Mechanism and management of headache. Elsevier, New York
Dodick DW, Eross EJ, Parish JM (2003) Clinical, anatomical, and physiologic relationship between sleep and headache. Headache 43:282-92
Jennum P, Jensen R (2002) Sleep and headache. Sleep Med Rev 6:471-79
Pearce JMS (1988) Exploding head syndrome. Lancet 2:270-71
Pearce JMS (1989) Clinical-features of the exploding head syndrome. J Neurol Neurosurg Psychiatry 52:907-10
Gilbert GJ (1982) Turtle headaches. J Am Med Assoc 248:921
Arjona JAM, Jimenez-Jimenez FJ, Vela-Bieno A, Tallon-Barranco A (2000) Hypnic headache associated with stage 3 slow wave sleep. Headache 40:753-54
Capuano A, Vollono C, Rubino M, Mei D, Cali C, De Angelis A, Di Trapani G, Servidei S, Della Marca G (2005) Hypnic headache: actigraphic and polysomnographic study of a case. Cephalalgia 25:466-69
Centonze V, D'Amico D, Usai S, Causarano V, Bassi A, Bussone G (2001) First Italian case of hypnic headache, with literature review and discussion of nosology. Cephalalgia 21:71-4
Dodick DW, Mosek AC, Campbell JK (1998) The hypnic (“alarm clock- headache syndrome. Cephalalgia 18:152-56
Dodick DW (2000) Polysomnography in hypnic headache syndrome. Headache 40:748-52
Dodick DW, Jones JM, Capobianco DJ (2000) Hypnic headache: another indomethacin-responsive headache syndrome? Headache 40:830-35
Domitrz I (2005) Hypnic headache as a primary short-lasting night headache: a report of two cases. Neurol Neurochir Pol 39:77-9
Evers S, Rahmann A, Schwaag S, Ludemann P, Husstedt I-W (2003) Hypnic headache—the first German cases including polysomnography. Cephalalgia 23:20-3
Ghiotto N, Sances G, Di Lorenzo G, Trucco M, Loi M, Sandrini G, Nappi G (2002) Report of eight new cases of hypnic headache and mini-review of the literature. Funct Neurol 17:211-19
Gould JD, Silberstein SD (1997) Unilateral hypnic headache: a case study. Neurology 49:1749-751
Grosberg BM, Lipton RB, Solomon S, Ballaban-Gil K (2005) Hypnic headache in childhood? A case report. Cephalalgia 25:68-0
Ivanez V, Soler R, Barreiro P (1998) Hypnic headache syndrome: a case with good response to indomethacin. Cephalalgia 18:225-26
Klimek A, Sklodowski P (1999) Night headache: report of 2 cases. Neurol Neurochir Pol 33:49-4
Kocasoy Orhan E, Kayrak Ertas N, Orhan KS, Ertas M (2004) Hypnic headache syndrome: excessive periodic limb movements in polysomnography. Agri 16:28-0
Lisotto C, Mainardi F, Maggioni F, Zanchin G (2004) Episodic hypnic headache? Cephalalgia 24:681-85
Manni R, Sances G, Terzaghi M, Ghiotto N, Nappi G (2004) Hypnic headache: PSG evidence of both REM- and NREM-related attacks. Neurology 62:1411-413
Martins IP, Gouveia RG (2001) Hypnic headache and travel across time zones: a case report. Cephalalgia 21:928-31
Moon HS, Chung CS, Hong SB, Kim YB, Chung PW (2006) A case of symptomatic hypnic headache syndrome. Cephalalgia 26:81-3
Morales-Asin F, Mauri JA, Iniguez C, Espada F, Mostacero E (1998) The hypnic headache syndrome: report of three new cases. Cephalalgia 18:157-58
Newman LC, Lipton RB, Solomon S (1990) The hypnic headache syndrome: a benign headache disorder of the elderly. Neurology 40:1904-905
Newman LC, Lipton RB, Solomon S (1991) The hypnic headache syndrome. In: Rose FC (ed) New advances in headache research. Smith-Gordon, London, pp 31-4
Patsouros N, Laloux P, Ossemann M (2004) Hypnic headache: a case report with polysomnography. Acta Neurol Belg 104:37-0
Peatfield RC, Mendoza ND (2003) Posterior fossa meningioma presenting as hypnic headache. Headache 43:1007-008
Perez-Martinez DA, Berbel-Garcia A, Puente-Munoz AI, Saiz-Diaz RA, de Toledo-Heras M (1999) Hypnic headache: a new case. Revue Neurologie 28:883-84
Peters N, Lorenzl S, Fischereder J, Botzel K, Straube A (2006) Hypnic headache: a case presentation including polysomnography. Cephalalgia 26:84-6
Pinessi L, Rainero I, Cicolin A, Zibetti M, Gentile S, Mutani R (2003) Hypnic headache syndrome: association of the attacks with REM sleep. Cephalalgia 23:150-54
Pinto CAR, Fragoso YD, de Souza Carvalho D, Gabbai AA (2002) Hypnic headache syndrome: clinical aspects of eight patients in Brazil. Cephalalgia 22:824-27
Queiroz LP, Coral LC (1997) The hypnic headache syndrome—a case report. Cephalalgia 17:303
Raskin NH (1988) The hypnic headache syndrome. Headache 28:534-36
Relja G, Zorzon M, Locatelli L, Carraro N, Antonello RM, Cazzato G (2002) Hypnic headache: rapid and long-lasting response to prednisone in two new cases. Cephalalgia 22:157-59
Sibon I, Ghorayeb I, Henry P (2003) Successful treatment of hypnic headache syndrome with acetazolamide. Neurology 61:1157-158
Skobieranda FG, Lee TG, Solomon GD (1997) The hypnic headache syndrome: six additional patients. Cephalalgia 17:304-05
Trucco M, Maggioni F, Badino R, Zanchin G (2000) Hypnic headache syndrome: report of a new Italian case. Cephalalgia 20:312
Vieira-Dias M, Esperanca P (2000) Hypnic headache: report of two cases. Cephalalgia 20:312
Vieira Dias M, Esperanca P (2002) Hypnic headache: a report of four cases. Rev Neurol 34:950-51
Staessen JA, Wang J, Bianchi G, Birkenhager WH (2003) Essential hypertension. Lancet 361:1629-641
Cirignotta F, Coccagna G, Sacquegna T, Sforza E, Lamontanara G, Zucconi M, Cortelli P, Lugaresi E (1983) Nocturnal headache: systemic arterial pressure and heart rate during sleep. Cephalalgia 3:54-7
Cugini P, Granata M, Strano S, Ferrucci A, Ciavarella GM, Di Palma L, Leone G, Giacovazzo M (1992) Nocturnal headache-hypertension syndrome: a chronobiologic disorder. Chronobiol Int 9:310-13
Schrader H, Stovner LJ, Helde G, Sand T, Bovim G (2001) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study. Br Med J 322:1-9
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Gil-Gouveia, R., Goadsby, P.J. Secondary “hypnic headache-. J Neurol 254, 646–654 (2007). https://doi.org/10.1007/s00415-006-0424-4
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DOI: https://doi.org/10.1007/s00415-006-0424-4