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Death by band-aid: fatal misuse of transdermal fentanyl patch

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Abstract

We present a case of fatal intoxication by the application of a transdermal fentanyl patch upon a superficial bleeding abrasion of a 2-year-old girl. The grandmother discovered the body of the child in bed at approximately 7 a.m. External examination revealed a properly developed, nourished, and hydrated child, with some vomit in the nostrils and inside the mouth. There was no evidence of trauma besides small contusions and abrasions on the knees, with a patch placed over the largest abrasion. Closer inspection revealed that this was transdermal fentanyl patch. Internal examination and microscopic analysis revealed regurgitation of stomach content, cerebral and pulmonary edema, and liver congestion. Toxicology analysis revealed trace levels of fentanyl in the blood just above the limit of detection (2 ng/mL), while concentrations in the urine, liver, and kidney were approximately 102, 28, and 10 ng/mL, respectively. Investigation discovered that the child injured her knee while playing the evening before. The grandmother applied the patch to cover the injury, unaware that she had used a fentanyl transdermal patch instead of simple band-aid. Although fatal intoxications are uncommon among young children in high-income countries, it is of major interest to raise awareness of such events especially since a great majority of these are preventable. The presented case points at the need for more thorough education of users and more strict rules in prescribing and handling of this potent medicine. As well, we find this case to be a useful contribution to the evaluation of postmortem fentanyl concentrations in fatal intoxication in a small child.

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References

  1. Anonymous (2011) Causes of death 2008 summary tables. Health Statistics and Informatics Department, World Health Organization, Geneva, Switzerland http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&ved=0CDAQFjAC&url=http%3A%2F%2Fwww.who.int%2Fgho%2Fmortality_burden_disease%2Fglobal_burden_disease_DTHMDG_2008.xls&ei=GorOVLnuBebOygPdvoGYCA&usg=AFQjCNF99dF9V77uAjzLyDbENLDpKBU3jQ&bvm=bv.85076809,d.bGQ Accessed 1 February 2015

  2. Bronstein AC, Spyker DA, Cantilena LR Jr, Rumack BH, Dart RC (2012) 2011 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila) 50(10):911–1164

    Article  Google Scholar 

  3. Bond GR, Woodward RW, Ho M (2012) The growing impact of pediatric pharmaceutical poisoning. J Pediatr 160(2):265–270

    Article  PubMed  Google Scholar 

  4. Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Dart RC (2011) 2010 Annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 28th Annual Report. Clin Toxicol (Phila) 49:910–941

    Article  Google Scholar 

  5. Hardwick WE Jr, King WD, Palmison PA (1997) Respiratory depression in a child unintentionally exposed to transdermal fentanyl patch. South Med J 90:962–964

    Article  PubMed  Google Scholar 

  6. Meyer D, Tobias JD (2005) Adverse effects following the inadvertent administration of opioids to infants and children. Clin Pediatr (Phila) 44(6):499–503

    Article  Google Scholar 

  7. Foy L, Seeyave DM, Bradin SA (2011) Toxic leukoencephalopathy due to transdermal fentanyl overdose. Pediatr Emer Care 27:854–856

    Article  Google Scholar 

  8. Lyttle MD, Verma S, Isaac R (2012) Transdermal fentanyl in deliberate overdose in pediatrics. Pediatr Emer Care 28:436–464

    Article  Google Scholar 

  9. Watson WA, Litovitz TL, Rodgers GC Jr, Klein-Schwartz W, Youniss J, Rose SR, Borys D, May ME (2003) 2002 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 21(5):353–421

    Article  PubMed  Google Scholar 

  10. Teske J, Weller JP, Larsch K, Troger HD, Karst M (2007) Fatal outcome in a child after ingestion of a transdermal fentanyl patch. Int J Legal Med 121:147–151

    Article  PubMed  Google Scholar 

  11. Anonymous (2012) Fentanyl patch can be deadly to children. Consumer health information Food and Drug Administration http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm300803.htm Accessed 30 January 2015

  12. Anonymous (2005) FDA issues public health advisory on the fentanyl patch. Consumer health information Food and Drug Administration http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2005/ucm108461.htm Accessed 30 Jan 2015

  13. Anonymous (2007) Second safety warning on fentanyl skin patch. Consumer health information Food and Drug Administration http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm100223.htm Accessed 30 Jan 2015

  14. Roy SD, Flynn GL (1990) Transdermal delivery of narcotic analgesics: pH, anatomical, and subject influences on cutaneous permeability of fentanyl and sufentanil. Pharm Res 7:842–847

    Article  CAS  PubMed  Google Scholar 

  15. Gupta SK, Southam M, Gale R, Hwang SS (1992) System functionality and physicochemical model of fentanyl transdermal system. J Pain Symptom Manage 7:S17–S26

    Article  CAS  PubMed  Google Scholar 

  16. Peng PW, Sandler AN (1999) A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology 90:576–599

    Article  CAS  PubMed  Google Scholar 

  17. Andresen H, Gullans A, Veselinovic M, Anders S, Schmoldt A, Iwersen-Bergmann S, Mueller A (2012) Fentanyl: toxic or therapeutic? Postmortem and antemortem blood concentrations after transdermal fentanyl application. J Anal Toxicol 36(3):182–194

    Article  CAS  PubMed  Google Scholar 

  18. Grond S, Radbruch L, Lehmann KA (2000) Clinical pharmacokinetics of transdermal opioids: focus on transdermal fentanyl. Clin Pharmacokinet 38:59–89

    Article  CAS  PubMed  Google Scholar 

  19. McClain DA, Hug CC (1980) Intravenous fentanyl kinetics. Clin Pharmacol Ther 128:106–114

    Article  Google Scholar 

  20. Mather LE, Gourlay GK (1991) Pharmacokinetics of fentanyl. In: Lehmann KA, Zech D (eds) Transdermal fentanyl: a new approach to prolonged pain control. Springer, Berlin Heidelberg, pp 73–97

    Chapter  Google Scholar 

  21. Anderson B, Lerman J, Cote CJ (2013) Pharmacokinetics and pharmacology of drugs used in children. In: Cote CJ, Lerman J, Anderson B (eds) A practice of anesthesia for infants and children, 5th edn. Elsevier Saunders, Philadelphia, pp 77–150

    Google Scholar 

  22. Kuhlman JJ, McCaulley R, Valouch TJ, Behonick GS (2003) Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases. J Anal Toxicol 27:499–504

    Article  CAS  PubMed  Google Scholar 

  23. Martin TL, Woodall KL, McLellan BA (2006) Fentanyl-related deaths in Ontario, Canada: toxicological findings and circumstances of death in 112 cases (2002–2004). J Anal Toxicol 30:603–610

    Article  CAS  PubMed  Google Scholar 

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The presented content completely complies with the laws in Croatia.

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Correspondence to Davor Mayer.

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Bakovic, M., Nestic, M. & Mayer, D. Death by band-aid: fatal misuse of transdermal fentanyl patch. Int J Legal Med 129, 1247–1252 (2015). https://doi.org/10.1007/s00414-015-1209-z

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  • DOI: https://doi.org/10.1007/s00414-015-1209-z

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