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Association of common variants in NOS1AP gene with sudden unexplained nocturnal death syndrome in the southern Chinese Han population

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Abstract

Here, we investigate the association of common polymorphisms of the NOS1AP gene with sudden unexplained nocturnal death syndrome (SUNDS) in the southern Chinese Han population. We genetically screened five common NOS1AP polymorphisms (rs10918594, rs12143842, rs16847548, rs12567209, and rs10494366) previously reported to be associated with QT interval variation and sudden cardiac death (SCD) in 123 sporadic SUNDS cases and 166 healthy controls using polymerase chain reaction (PCR) and direct DNA sequencing. In the present study, the A allele of rs12567209 was more common in controls than in SUNDS cases, which was associated with 0.656-fold decreased risk of SUNDS (95 % confidence interval 0.431 to 0.998, P = 0.048) compared with G allele. Under the dominant genetic model, GA + AA genotype of rs12567209 was also more common in controls than in SUNDS cases, which was associated with 0.604-fold decreased risk of SUNDS (95 % confidence interval 0.368 to 0.991, P = 0.045) compared with GG genotype. No significant associations of rs10918594, rs12143842, rs16847548, and rs10494366 with SUNDS were observed (P > 0.05). In haplotype analyses, the distribution of haplotype GCTA was significantly overrepresented in controls compared to SUNDS cases (P = 0.040). This is the first report of the association of common NOS1AP polymorphisms with SUNDS in the southern Chinese Han population. These findings suggest that the A allele of rs12567209 and haplotype GCTA may serve as a protective modifier.

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Conflict of interest

None.

Acknowledgement

This work was supported by the National Natural Science Foundation of China (81172901, 81373238), the Fundamental Research Funds for the Central Universities (11ykpy04), the Technological Infrastructure Work Special Projects of Ministry of Public Security of China (2012GABJC010), and the Natural Science Foundation of Guangdong (S2012010009045).

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Authors and Affiliations

  1. Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China

    Lei Huang, Shuangbo Tang & Jianding Cheng

  2. Guangdong Institute of Forensic Science, Guangzhou, 510050, China

    Yangeng Yu & Zichuang Yuan

  3. Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China

    Yili Chen

  4. Departments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA

    David J. Tester & Michael J. Ackerman

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  1. Lei Huang
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Correspondence to Jianding Cheng.

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Lei Huang, Yangeng Yu, and Yili Chen contributed equally to this work.

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Huang, L., Yu, Y., Chen, Y. et al. Association of common variants in NOS1AP gene with sudden unexplained nocturnal death syndrome in the southern Chinese Han population. Int J Legal Med 128, 933–938 (2014). https://doi.org/10.1007/s00414-014-0973-5

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