Abstract
The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.
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The study was financially supported by the IISC-MHRD Start-Up Grant, the Ramalingaswamy-DBT Fellowship to SG, and the IISC-DBT Partnership Program.
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SG conceptualized the manuscript. SG, HK, and PRV wrote, edited, and proofread the manuscript. PRV illustrated the artwork.
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Kaur, H., RV, P. & Gayen, S. Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?. Chromosoma 129, 111–113 (2020). https://doi.org/10.1007/s00412-019-00717-5
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DOI: https://doi.org/10.1007/s00412-019-00717-5