Abstract
COTI (collar therapy indicator) has been recently introduced for the detection of gamma rays with emphasis on thyroid investigations. The aim of this study was to test the feasibility of a prototype version of COTI including activity detectors with low sensitivity in performing thyroid uptake measurements for a large group of patients. Consequently, thyroid uptake tests were carried out for a total of 89 patients (22 males and 67 females; age: 44 ± 13 years) with thyroid cancer (n = 74), hyperthyroidism (n = 16) at 2 and 24 h after administration of 0.44–2 MBq of 131I. Eight individuals among the thyroid cancer patients were monitored up to 96 h after administration. The COTI device was equipped with two CsI (Tl) detectors, known as LoHi type, sensitive to activity ranges from 0.02 to 30 MBq of 131I. The uptake values from COTI were compared with those measured with a standard probe. It was found that the mean uptake of thyroid activity in thyroid cancer patients was 2.1 ± 1.3% at 2 h when measured with the standard probe, while it was 2.2 ± 1.2% when measured with COTI. In addition, the average uptake at 24 h after administration was 2.5 ± 3.2% and 3.2 ± 3.8% measured with COTI and the standard probe, respectively. A strong correlation was found at 24 h between the results obtained with COTI and the standard probe, while a weaker correlation was seen at 2 h. Overall, there was no significant difference between the results obtained with the standard probe and those obtained with COTI at both 2 and 24 h (Pvalue ≥ 0.05). Besides, 85% of the uptake values measured with COTI were less than those measured with the standard probe at the 24 h after administration. The average uptake value was 0.9 ± 0.8% after 96 h by COTI, and 1.4 ± 1.3% by the standard probe. Pertaining to the hyperthyroidism patients, COTI showed mean uptake values of 20 ± 16% and 23 ± 18% at 2 and 24 h, respectively. In contrast, the standard probe suggested higher mean uptake values of 26 ± 18% and 30 ± 22%, respectively. It is concluded that the prototype of COTI used in the present study has been proved to be a feasible and promising tool in thyroid investigations. It is noted, however, that the next COTI generation should include detectors equipped with collimator and energy discrimination.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abuqbeitah M, Demir M, Çavdar İ, Tanyildizi H, Yeyin N, Uslu-Beşli L, Kabasakal L, Işıkcı Nİ, Sönmezoğlu K (2018a) Red bone marrow dose estimation using several internal dosimetry models for prospective dosimetry-oriented radioiodine therapy. Radiat Environ Biophys 57(4):395–404. https://doi.org/10.1007/s00411-018-0757-2
Abuqbeitah M, Demir M, Kabasakal L, Çavdar I, Uslu-Beşli L, Yeyin N, Razavikhoshahi SB, Sönmezoğlu K (2018b) Indirect assessment of the maximum empirical activity (250 mCi) with respect to dosimetry concepts in radioiodine therapy of metastatic differentiated thyroid cancer. Nucl Med Commun 39(11):969–975. https://doi.org/10.1097/MNM.0000000000000900
Barber HB, Barrett HH, Hickernell TS, Kwo DP, Woolfenden JM, Entine G, Ortale Baccash C (1991) Comparison of NaI(Tl), CdTe, and HgI2 surgical probes: physical characterization. Med Phys 18(3):373–381. https://doi.org/10.1118/1.596717
Benvenga S, Tuccari G, Ieni A, Vita R (2018) Thyroid gland: anatomy and physiology. In Reference Module in Biomedical Sciences. Elsevier, Amsterdam. https://doi.org/10.1016/B978-0-12-801238-3.96022-7
Brinks P, Van Gils K, Kranenborg E, Lavalaye J, Dickerscheid DBM, Habraken JBA (2017) Measuring the actual I-131 thyroid uptake curve with a collar detector system: a feasibility study. Eur J Nucl Med Mol Imaging 44(6):935–940. https://doi.org/10.1007/s00259-016-3595-y
Hänscheid H, Cristina C, Wolfgang E, Glenn F, Markus L, Lidia S, Michael L (2013) EANM dosimetry committee series on standard operational procedures for pre-therapeutic dosimetry II. Dosimetry prior to radioiodine therapy of benign thyroid diseases. Eur J Nucl Med Mol Imaging 40(7):1126–1134
Khoshakhlagh M, Islamian JP, Abedi SM, Mahmoudian B (2015) Development of scintillators in nuclear medicine. World J Nucl Med 14(3):156–159. https://doi.org/10.4103/1450-1147.163241
Kostic I, Curcio F (2012) Causes of hypothyroidism. In: Hypothyroidism—influences and treatments. InTech. https://doi.org/10.5772/32571
Kovaltchouk VD, Lolos GJ, Papandreou Z, Wolbaum K (2005) Comparison of a silicon photomultiplier to a traditional vacuum photomultiplier. Nucl Inst Meth Phys Res Sect A Accel Spectrom Detect Assoc Equip 538(1–3):408–415. https://doi.org/10.1016/j.nima.2004.08.136
McDermott MT, Ridgway EC (1998) Central hyperthyroidism. Endocrinol Metab Clin North Am 27(1):187–203. https://doi.org/10.1016/S0889-8529(05)70306-6
Stokkel MPM, Handkiewicz Junak D, Lassmann M, Dietlein M, Luster M (2010) EANM procedure guidelines for therapy of benign thyroid disease. Eur J Nucl Med Mol Imaging 37(11):2218–2228. https://doi.org/10.1007/s00259-010-1536-8
Van Gils K, Brinks P, Lavalaye J, Verberne HJ, Habraken JBA (2017) A method to measure the absorbed dose of the thyroid during I-131 therapy, using a collar detector system and a SPECT acquisition. Med Phys 44(10):5450–5456. https://doi.org/10.1002/mp.12472
Verburg FA, Luster M, Giovanella L et al (2017) The “reset button” revisited: why high activity 131I therapy of advanced differentiated thyroid cancer after dosimetry is advantageous for patients. Eur J Nucl Med Mol Imaging 44(6):915–917. https://doi.org/10.1007/s00259-017-3649-9
Acknowledgements
The authors would like to thank Lotus Medical for supplying the COTI device.
Funding
This research never received specific grant from public funding agencies or any commercial sources.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All of the authors declare no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. The authorship of AG Medical member is not believed to influence the content of the paper.
Ethical approval
All of the procedures involving human participation were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by Istanbul University Cerrahpaşa Medical Faculty Clinical Research Ethics Committee (document number: 19451483/604-01-02-52947).
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Abuqbeitah, M., Demir, M., Yeyin, N. et al. Thyroid uptake test with portable device (COTI) after 131I tracer administration: proof of concept. Radiat Environ Biophys 59, 553–558 (2020). https://doi.org/10.1007/s00411-020-00849-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00411-020-00849-8